(Q84581239)

English

Decreased levels of PSD95 and two associated proteins and increased levels of BCl2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation

scientific article published on 01 February 2010

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scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19774677%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Decreased levels of PSD95 and two associated proteins and increased levels of BCl2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation of Abeta, and neurodegeneration in a prodromal stage of Alzheimer's disease (English)

1 reference

Europe PubMed Central

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8 February 2020

mild cognitive impairment

1 reference

based on heuristic

inferred from title

cognitive dysfunction

1 reference

based on heuristic

inferred from title

William A Banks

2

object named as

William A Banks

1 reference

Europe PubMed Central

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8 February 2020

author name string

Rukhsana Sultana

1

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8 February 2020

D Allan Butterfield

3

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8 February 2020

publication date

1 February 2010

1 reference

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8 February 2020

Journal of Neuroscience Research

1 reference

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8 February 2020

88

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8 February 2020

469-477

1 reference

Europe PubMed Central

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8 February 2020

3

1 reference

Europe PubMed Central

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8 February 2020

Alterations in expression of glutamatergic transporters and receptors in sporadic Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated levels of 3-nitrotyrosine in brain from subjects with amnestic mild cognitive impairment: implications for the role of nitration in the progression of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein oxidation in the brain in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The -48 C/T polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased Abeta load in brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysregulation of cellular calcium homeostasis in Alzheimer's disease: bad genes and bad habits

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of the low-density lipoprotein receptor-related protein (LRP1) in Alzheimer's A beta generation: development of a cell-based model system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid beta-peptide (1-42) in a transgenic Caenorhabditis elegans model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coincidence in dendritic clustering and synaptic targeting of homer proteins and NMDA receptor complex proteins NR2B and PSD95 during development of cultured hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitation of NMDA receptor NR2 mRNA transcripts in human brain by competitive RT-PCR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ethanol-induced alteration in N-methyl-D-aspartate receptor 2A C-terminus and protein kinase C activity in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical and molecular studies of NMDA receptor subunits NR1/2A/2B in hippocampal subregions throughout progression of Alzheimer's disease pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two apolipoprotein E mimetic peptides, ApoE(130-149) and ApoE(141-155)2, bind to LRP1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mild cognitive impairment as a diagnostic entity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta solubility and deposition during AD progression and in APPxPS-1 knock-in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral clearance of human amyloid-beta peptide (1-40) across the blood-brain barrier is reduced by self-aggregation and formation of low-density lipoprotein receptor-related protein-1 ligand complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Volumetric MRI vs clinical predictors of Alzheimer disease in mild cognitive impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional role of lipoprotein receptors in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of phospholipid asymmetry and elevated brain apoptotic protein levels in subjects with amnestic mild cognitive impairment and Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inflammatory hypothesis of Alzheimer disease: dead or alive?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated levels of pro-apoptotic p53 and its oxidative modification by the lipid peroxidation product, HNE, in brain from subjects with amnestic mild cognitive impairment and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Postsynaptic density protein PSD-95 expression in Alzheimer's disease and okadaic acid induced neuritic retraction

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein levels and activity of some antioxidant enzymes in hippocampus of subjects with amnestic mild cognitive impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic and neuritic alterations during the progression of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoreactivity for Bcl-2 protein within neurons in the Alzheimer's disease brain increases with disease severity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro and in vivo oxidative stress associated with Alzheimer's amyloid beta-peptide (1-42)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The origins of Alzheimer disease: a is for amyloid.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mild cognitive impairment: transition between aging and Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-Methyl-D-aspartate receptor subunit proteins and their phosphorylation status are altered selectively in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulation of Bcl-2 is associated with neuronal DNA damage in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cortical NMDA receptor properties and membrane fluidity are altered in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological heterogeneity of NMDA receptors: characterization of NR1a/NR2D heteromers expressed in Xenopus oocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebrospinal fluid tau and Abeta42 as predictors of development of Alzheimer's disease in patients with mild cognitive impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The NR1-4 C-terminus interferes with N-methyl-D-aspartate receptor-mediated excitotoxicity: evidence against a typical T/SXV-PDZ interaction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteomic identification of proteins specifically oxidized by intracerebral injection of amyloid beta-peptide (1-42) into rat brain: implications for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CSF biomarkers for mild cognitive impairment and early Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence of increased oxidative damage in subjects with mild cognitive impairment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association study and meta-analysis of low-density lipoprotein receptor related protein in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of NMDA receptor trafficking by amyloid-beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ribosome dysfunction is an early event in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms of lipoprotein receptor signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A 3'-UTR polymorphism in the oxidized LDL receptor 1 gene increases Abeta40 load as cerebral amyloid angiopathy in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[What is a mild cognitive impairment?].

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E receptor 2 interactions with the N-methyl-D-aspartate receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropathologic changes in Alzheimer's disease: potential targets for treatment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Premorbid effects of APOE on synaptic proteins in human temporal neocortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress in Alzheimer's disease brain: new insights from redox proteomics

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Seeing is believing: neuroimaging adds to our understanding of cerebral pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of PSD proteins in age-related spatial learning impairments.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19774677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/JNR.22227

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19774677%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19774677%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19774677%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

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