(Q64360450)

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Adeno-associated Viral (AAV) Serotype 5 Vector Mediated Gene Delivery of Endothelin-converting Enzyme Reduces Aβ Deposits in APP + PS1 Transgenic Mice

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Adeno-associated Viral (AAV) Serotype 5 Vector Mediated Gene Delivery of Endothelin-converting Enzyme Reduces Aβ Deposits in APP + PS1 Transgenic Mice (English)

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author name string

Niki C Carty

1

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Kevin Nash

2

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Daniel Lee

3

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Mary Mercer

4

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Paul E Gottschall

5

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Craig Meyers

6

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Nicholas Muzyczka

7

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Marcia N Gordon

8

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Dave Morgan

9

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language of work or name

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publication date

September 2008

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Molecular Therapy

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16

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9

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1580-1586

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

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A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

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The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

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Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice.

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Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ

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Targeting amyloid-degrading enzymes as therapeutic strategies in neurodegeneration

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Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders

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Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide.

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Rat endothelin-converting enzyme-1 forms a dimer through Cys412 with a similar catalytic mechanism and a distinct substrate binding mechanism compared with neutral endopeptidase-24.11

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Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme

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A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

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Heterodimerization of endothelin-converting enzyme-1 isoforms regulates the subcellular distribution of this metalloprotease

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Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme

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Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse

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Nerve growth factor gene therapy in Alzheimer disease

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In vitro analysis of mouse neural stem cells genetically modified to stably express human NGF by a novel multigenic viral expression system.

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Anti-Abeta single-chain antibody delivery via adeno-associated virus for treatment of Alzheimer's disease

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Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid beta, amyloid beta40, and amyloid beta42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice.

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Oral vaccination with a viral vector containing Abeta cDNA attenuates age-related Abeta accumulation and memory deficits without causing inflammation in a mouse Alzheimer model

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Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

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Herpes simplex virus RNAi and neprilysin gene transfer vectors reduce accumulation of Alzheimer's disease-related amyloid-beta peptide in vivo

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Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging

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Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme

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10.1038/MT.2008.148

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