(Q64376808)

1

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Ken Kadoya

2

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Matthew Hirsch

3

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Richard J Samulski

AAV hybrid serotypes: improved vectors for gene delivery

4

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language of work or name

English

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publication date

February 2008

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published in

Molecular Therapy

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volume

16

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issue

2

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page(s)

296-301

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cites work

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Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis

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Self-complementary adeno-associated virus serotype 2 vector: global distribution and broad dispersion of AAV-mediated transgene expression in mouse brain

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Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo

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Immune responses to AAV in a phase I study for Canavan disease.

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Treatment of human disease by adeno-associated viral gene transfer

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Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model.

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Intramuscular viral delivery of paraplegin rescues peripheral axonopathy in a model of hereditary spastic paraplegia

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Intraneural colchicine inhibition of adenoviral and adeno-associated viral vector remote spinal cord gene delivery

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Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system

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Adeno-associated virus type 6 (AAV6) vectors mediate efficient transduction of airway epithelial cells in mouse lungs compared to that of AAV2 vectors

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Adeno-associated virus type 5 (AAV5) but not AAV2 binds to the apical surfaces of airway epithelia and facilitates gene transfer

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Noninvasive gene transfer to the lung for systemic delivery of therapeutic proteins.

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Enhancing rAAV vector expression in the lung

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Recombinant AAV serotype 1 transduction efficiency and tropism in the murine brain

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Several log increase in therapeutic transgene delivery by distinct adeno-associated viral serotype vectors

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Efficiency of eight different AAV serotypes in transducing rat myocardium in vivo

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Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain

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Adeno-associated virus serotypes 1 to 5 mediated tumor cell directed gene transfer and improvement of transduction efficiency

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Promoters and serotypes: targeting of adeno-associated virus vectors for gene transfer in the rat central nervous system in vitro and in vivo

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Targeted retrograde gene delivery for neuronal protection

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Role for highly regulated rep gene expression in adeno-associated virus vector production

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