(Q64381079)

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Dopa-producing astrocytes generated by adenoviral transduction of human tyrosine hydroxylase gene: in vitro study and transplantation to hemiparkinsonian model rats

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3 November 2019

Dopa-producing astrocytes generated by adenoviral transduction of human tyrosine hydroxylase gene: in vitro study and transplantation to hemiparkinsonian model rats (English)

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3 November 2019

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H Hida

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3 November 2019

M Hashimoto

2

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3 November 2019

I Fujimoto

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3 November 2019

K Nakajima

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3 November 2019

Y Shimano

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3 November 2019

T Nagatsu

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3 November 2019

K Mikoshiba

7

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3 November 2019

H Nishino

8

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3 November 2019

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1 November 1999

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3 November 2019

Neuroscience Research

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3 November 2019

35

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3 November 2019

2

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3 November 2019

101-112

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3 November 2019

Transfer of a foreign gene into the brain using adenovirus vectors

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Double transduction with GTP cyclohydrolase I and tyrosine hydroxylase is necessary for spontaneous synthesis of L-DOPA by primary fibroblasts

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Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants

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Adenovirus gene transfer causes inflammation in the brain

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Immunological instability of persistent adenovirus vectors in the brain: peripheral exposure to vector leads to renewed inflammation, reduced gene expression, and demyelination

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Direct intracerebral nerve growth factor gene transfer using a recombinant adenovirus: effect on basal forebrain cholinergic neurons during aging.

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Highly efficient adenovirus-mediated gene transfer into renal cells in culture

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Dopaminergic neurons protected from degeneration by GDNF gene therapy

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A model system for in vivo gene transfer into the central nervous system using an adenoviral vector

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Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase

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Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce l-dopa

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Gene therapy of murine motor neuron disease using adenoviral vectors for neurotrophic factors

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A neural cell-type-specific expression system using recombinant adenovirus vectors.

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Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's disease

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Decarboxylation of L-dopa by cultured mouse astrocytes

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A simple and efficient method for purification of infectious recombinant adenovirus.

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Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase

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Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain

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The principles of gene therapy for the nervous system

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Development of cell lines capable of complementing E1, E4, and protein IX defective adenovirus type 5 mutants

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Adenoviral vector-mediated GDNF gene therapy in a rodent lesion model of late stage Parkinson's disease

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An adenovirus vector for gene transfer into neurons and glia in the brain

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Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease.

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Gene expression of aromatic L-amino acid decarboxylase in cultured rat glial cells

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Generation of DOPA-producing astrocytes by retroviral transduction of the human tyrosine hydroxylase gene: in vitro characterization and in vivo effects in the rat Parkinson model

1 reference

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Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats

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Immortalized neural progenitor cells for CNS gene transfer and repair.

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Identifiers

10.1016/S0168-0102(99)00073-5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10616914%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10616914%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

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