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A DNA damage response pathway controlled by Tel1 and the Mre11 complex
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title
A DNA damage response pathway controlled by Tel1 and the Mre11 complex
(English)
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author name string
T Usui
series ordinal
1
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H Ogawa
series ordinal
2
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J H Petrini
series ordinal
3
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language of work or name
English
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publication date
June 2001
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published in
Molecular Cell
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volume
7
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issue
6
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page(s)
1255-66
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cites work
A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains
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Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination
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DNA repair protein Rad55 is a terminal substrate of the DNA damage checkpoints
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DMC1: a meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression
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Direct Coupling Between Meiotic DNA Replication and Recombination Initiation
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The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response
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Characterization of Schizosaccharomyces pombe Hus1: a PCNA-related protein that associates with Rad1 and Rad9
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Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants
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RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation
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Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair
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A Rad3–Rad26 complex responds to DNA damage independently of other checkpoint proteins
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Cell cycle checkpoints: preventing an identity crisis
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MEC1-dependent phosphorylation of Rad9p in response to DNA damage
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Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint
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ATM-dependent phosphorylation of nibrin in response to radiation exposure
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A novel Rad24 checkpoint protein complex closely related to replication factor C.
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https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900270-2
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TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene
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The many interfaces of Mre11
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https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900270-2
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7 January 2021
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Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily
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An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae
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7 January 2021
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Covalent protein-DNA complexes at the 5' strand termini of meiosis-specific double-strand breaks in yeast
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Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family
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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
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Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation
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Yeast checkpoint genes in DNA damage processing: implications for repair and arrest
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A meiotic recombination checkpoint controlled by mitotic checkpoint genes
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Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase
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hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks
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DNA damage-dependent nuclear dynamics of the Mre11 complex
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The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance
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TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1
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Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae
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Rfc5, in cooperation with rad24, controls DNA damage checkpoints throughout the cell cycle in Saccharomyces cerevisiae
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In situ visualization of DNA double-strand break repair in human fibroblasts
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The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks
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https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900270-2
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7 January 2021
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Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase.
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The Mre11 complex and ATM: collaborating to navigate S phase
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The pachytene checkpoint
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Cloning and sequence analysis of the Saccharomyces cerevisiae RAD9 gene and further evidence that its product is required for cell cycle arrest induced by DNA damage
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Structural and functional similarities between the SbcCD proteins of Escherichia coli and the RAD50 and MRE11 (RAD32) recombination and repair proteins of yeast.
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Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart
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7 January 2021
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ATM and ATR: networking cellular responses to DNA damage
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Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein
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https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900270-2
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B-type cyclins CLB5 and CLB6 control the initiation of recombination and synaptonemal complex formation in yeast meiosis
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https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900270-2
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The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder
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https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900270-2
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Rfc5, a replication factor C component, is required for regulation of Rad53 protein kinase in the yeast checkpoint pathway
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https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900270-2
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Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways
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Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint
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Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95
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https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900270-2
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A novel mre11 mutation impairs processing of double-strand breaks of DNA during both mitosis and meiosis
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Complex formation and functional versatility of Mre11 of budding yeast in recombination
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https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900270-2
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Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900270-2
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The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage
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DNA topoisomerases
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DNA damage and checkpoint pathways: molecular anatomy and interactions with repair
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Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair
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https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900270-2
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7 January 2021
based on heuristic
inferred from DOI database lookup
ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response
1 reference
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https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900270-2
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inferred from DOI database lookup
Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells
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https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900270-2
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7 January 2021
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Meiotic cells monitor the status of the interhomolog recombination complex
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https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900270-2
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A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools
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https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900270-2
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7 January 2021
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Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
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https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900270-2
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7 January 2021
based on heuristic
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The DNA damage response: putting checkpoints in perspective
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Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.
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https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900270-2
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Identifiers
DOI
10.1016/S1097-2765(01)00270-2
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PubMed publication ID
11430828
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