(Q64898342)

30 June 2019

review article

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title

Immunoregulatory and anti-inflammatory properties of Crocus sativus (Saffron) and its main active constituents: A review. (English)

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30 June 2019

main subject

Crocus sativus

object named as

Crocus sativus

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Majid Zeinali

1

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30 June 2019

Mohammad Reza Zirak

2

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30 June 2019

Seyed Abdolrahim Rezaee

3

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30 June 2019

Gholamreza Karimi

4

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30 June 2019

Hossein Hosseinzadeh

5

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30 June 2019

publication date

1 April 2019

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30 June 2019

Iranian Journal of Basic Medical Sciences

published in

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30 June 2019

volume

22

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30 June 2019

issue

4

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30 June 2019

page(s)

334-344

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30 June 2019

Determination of saffron (Crocus sativus L.) components in crude plant extract using high-performance liquid chromatography-UV-visible photodiode-array detection-mass spectrometry

cites work

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12 December 2020

Flavonols from saffron flower: tyrosinase inhibitory activity and inhibition mechanism

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12 December 2020

Crocin suppresses tumor necrosis factor-alpha-induced cell death of neuronally differentiated PC-12 cells

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12 December 2020

Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice

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12 December 2020

MAPK signalling pathways as molecular targets for anti-inflammatory therapy--from molecular mechanisms to therapeutic benefits

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12 December 2020

Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents

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12 December 2020

Nitric oxide in the injured spinal cord: synthases cross-talk, oxidative stress and inflammation

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12 December 2020

Saffron in phytotherapy: pharmacology and clinical uses

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12 December 2020

A study of acute and chronic anti-nociceptive and anti-inflammatory effects of thiamine in mice.

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12 December 2020

Effect of safranal on extracellular hippocampal levels of glutamate and aspartate during kainic Acid treatment in anesthetized rats

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12 December 2020

Crocetin protects against cardiac hypertrophy by blocking MEK-ERK1/2 signalling pathway

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12 December 2020

Crocetin reduces TNBS-induced experimental colitis in mice by downregulation of NFkB.

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12 December 2020

The effect of an Iranian herbal drug on primary dysmenorrhea: a clinical controlled trial

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12 December 2020

Preventive effect of crocin of Crocus sativus on hemodynamic, biochemical, histopathological and ultrastuctural alterations in isoproterenol-induced cardiotoxicity in rats

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12 December 2020

Preventive effect of crocin in inflamed animals and in LPS-challenged RAW 264.7 cells

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12 December 2020

Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats

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12 December 2020

Neutrophil function in inflammation and inflammatory diseases

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12 December 2020

The nuclear factor NF-kappaB pathway in inflammation

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12 December 2020

Sub-acute effects of diazinon on biochemical indices and specific biomarkers in rats: protective effects of crocin and safranal

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12 December 2020

Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and placebo-controlled trial.

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12 December 2020

Role of nitric oxide and its metabolites as potential markers in lung cancer

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12 December 2020

Immunomodulatory effects of saffron: a randomized double-blind placebo-controlled clinical trial.

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12 December 2020

The role of crocetin in protection following cerebral contusion and in the enhancement of angiogenesis in rats.

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12 December 2020

The effect of Crocus sativus extract on human lymphocytes' cytokines and T helper 2/T helper 1 balance

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12 December 2020

Crocetin, a carotenoid derivative, inhibits VEGF-induced angiogenesis via suppression of p38 phosphorylation

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12 December 2020

Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial.

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12 December 2020

iNOS signaling interacts with COX-2 pathway in colonic fibroblasts

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12 December 2020

The effect of the extract of Crocus sativus and its constituent safranal, on lung pathology and lung inflammation of ovalbumin sensitized guinea-pigs

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12 December 2020

Avicenna's (Ibn Sina) the Canon of Medicine and saffron (Crocus sativus): a review.

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12 December 2020

Anti-arthritic effects of crocin in interleukin-1β-treated articular chondrocytes and cartilage in a rabbit osteoarthritic model

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12 December 2020

Anti-inflammatory properties of drugs from saffron crocus.

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12 December 2020

A dietary colorant crocin mitigates arthritis and associated secondary complications by modulating cartilage deteriorating enzymes, inflammatory mediators and antioxidant status

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12 December 2020

Saffron (Crocus sativus L.) increases glucose uptake and insulin sensitivity in muscle cells via multipathway mechanisms.

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12 December 2020

Th2 cytokine antagonists: potential treatments for severe asthma

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12 December 2020

The potential effect of the extract of Crocus sativus and safranal on the total and differential white blood cells of ovalbumin-sensitized guinea pigs

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12 December 2020

Saffron for treatment of fluoxetine-induced sexual dysfunction in women: randomized double-blind placebo-controlled study

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12 December 2020

Dietary Crocin Inhibits Colitis and Colitis-Associated Colorectal Carcinogenesis in Male ICR Mice

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12 December 2020

Evaluation of diazinon-induced hepatotoxicity and protective effects of crocin

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12 December 2020

Crocetin, a carotenoid derivative, inhibits retinal ischemic damage in mice

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12 December 2020

Safranal: from an aromatic natural product to a rewarding pharmacological agent

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12 December 2020

Crocin restores hypotensive effect of subchronic administration of diazinon in rats

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12 December 2020

Effect of Crocus sativus L. (saffron) on coagulation and anticoagulation systems in healthy volunteers

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12 December 2020

Saffron and natural carotenoids: Biochemical activities and anti-tumor effects.

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12 December 2020

Bioactivity assessment and toxicity of crocin: a comprehensive review

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12 December 2020

Effects of safranal, a constituent of saffron, and vitamin E on nerve functions and histopathology following crush injury of sciatic nerve in rats

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12 December 2020

Crocetin, a carotenoid from Gardenia jasminoides Ellis, protects against hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats

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12 December 2020

Antidepressant Effect of Crocus sativus Aqueous Extract and its Effect on CREB, BDNF, and VGF Transcript and Protein Levels in Rat Hippocampus.

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12 December 2020

The Synergic Effects of Crocus Sativus L. and Low Frequency Electromagnetic Field on VEGFR2 Gene Expression in Human Breast Cancer Cells

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12 December 2020

Crocin suppresses LPS-stimulated expression of inducible nitric oxide synthase by upregulation of heme oxygenase-1 via calcium/calmodulin-dependent protein kinase 4

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12 December 2020

The effect of safranal, a constituent of Crocus sativus (saffron), on tracheal responsiveness, serum levels of cytokines, total NO and nitrite in sensitized guinea pigs

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12 December 2020

Saffron aqueous extract prevents metabolic syndrome in patients with schizophrenia on olanzapine treatment: a randomized triple blind placebo controlled study.

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12 December 2020

Effects of saffron (Crocus sativus) petal ethanolic extract on hematology, antibody response, and spleen histology in rats

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12 December 2020

Ameliorative effect of saffron aqueous extract on hyperglycemia, hyperlipidemia, and oxidative stress on diabetic encephalopathy in streptozotocin induced experimental diabetes mellitus

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12 December 2020

Comparing the efficacy and safety of Crocus sativus L. with memantine in patients with moderate to severe Alzheimer's disease: a double-blind randomized clinical trial.

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12 December 2020

Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action.

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12 December 2020

Hepatoprotective effect of Crocus sativus (saffron) petals extract against acetaminophen toxicity in male Wistar rats.

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12 December 2020

Crocin, the main active saffron constituent, as an adjunctive treatment in major depressive disorder: a randomized, double-blind, placebo-controlled, pilot clinical trial.

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12 December 2020

Anti-asthma potential of crocin and its effect on MAPK signaling pathway in a murine model of allergic airway disease

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12 December 2020

Safranal of Crocus sativus L. inhibits inducible nitric oxide synthase and attenuates asthma in a mouse model of asthma

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12 December 2020

Bioactive compounds of Crocus sativus L. and their semi-synthetic derivatives as promising anti-Helicobacter pylori, anti-malarial and anti-leishmanial agents

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12 December 2020

Cardioprotective effect of saffron extracts against acute doxorubicin toxicity in isolated rabbit hearts submitted to ischemia-reperfusion injury

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12 December 2020

Crocetin downregulates the proinflammatory cytokines in methylcholanthrene-induced rodent tumor model and inhibits COX-2 expression in cervical cancer cells

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12 December 2020

Neuroprotective effects of safranal in a rat model of traumatic injury to the spinal cord by anti-apoptotic, anti-inflammatory and edema-attenuating

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12 December 2020

Saffron as an antidote or a protective agent against natural or chemical toxicities

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12 December 2020

Protective effect of crocetin against burn-induced intestinal injury

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12 December 2020

Suppressive effects of Mimosa pudica (L.) constituents on the production of LPS-induced pro-inflammatory mediators

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12 December 2020

Effect of crocin on nitric oxide synthase expression in post-ischemic isolated rat heart

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12 December 2020

Safranal as a safe compound to mice immune system

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12 December 2020

Saffron-Based Crocin Prevents Early Lesions of Liver Cancer: In vivo, In vitro and Network Analyses

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12 December 2020

Anti-atherogenic potential of jujube, saffron and barberry: anti-diabetic and antioxidant actions.

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12 December 2020

Crocin exerts anti-inflammatory and anti-catabolic effects on rat intervertebral discs by suppressing the activation of JNK.

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12 December 2020

Effect of cinnamon, cardamom, saffron and ginger consumption on blood pressure and a marker of endothelial function in patients with type 2 diabetes mellitus: A randomized controlled clinical trial.

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12 December 2020

Saffron: A Natural Potent Antioxidant as a Promising Anti-Obesity Drug

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12 December 2020

Razi's Al-Hawi and saffron (Crocus sativus): a review

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12 December 2020

Molecular Mechanism of Crocin Induced Caspase Mediated MCF-7 Cell Death: In Vivo Toxicity Profiling and Ex Vivo Macrophage Activation.

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12 December 2020

Effect of polymer/nanosilver composite packaging on long-term microbiological status of Iranian saffron (Crocus sativus L.).

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12 December 2020

A double-blind, randomized and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depression.

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12 December 2020

Anti-inflammatory and protective effects of saffron extract in ischaemia/reperfusion-induced acute kidney injury.

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12 December 2020

Therapeutic effects of saffron (Crocus sativus L.) in digestive disorders: a review

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12 December 2020

Saffron (Crocus sativus) pretreatment confers cardioprotection against ischemia-reperfusion injuries in isolated rabbit heart

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12 December 2020

Negative regulation of NF-κB p65 activity by serine 536 phosphorylation

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12 December 2020

Protective effects of saffron extract and crocin supplementation on fatty liver tissue of high-fat diet-induced obese rats

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12 December 2020

Safranal and its analogs inhibit Escherichia coli ATP synthase and cell growth.

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12 December 2020

Crocetin Inhibits Lipopolysaccharide-Induced Inflammatory Response in Human Umbilical Vein Endothelial Cells.

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12 December 2020

The Effect of Safranal on Th1/Th2 Cytokine Balance.

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12 December 2020

The effects of crocin, insulin and their co-administration on the heart function and pathology in streptozotocin-induced diabetic rats

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12 December 2020

Effects of salbutamol aerosol combined with magnesium sulfate on T-lymphocyte subgroup and Th1/Th2 cytokines of pediatric asthma

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12 December 2020

Immunomodulatory and antioxidant effects of saffron aqueous extract (Crocus sativus L.) on streptozotocin-induced diabetes in rats.

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12 December 2020

Metabolic effects of Crocus sativus and protective action against non-alcoholic fatty liver disease in diabetic rats

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12 December 2020

Immune System and Chronic Diseases.

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12 December 2020

Mechanism behind the anti-tumour potential of saffron (Crocus sativus L.): The molecular perspective

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12 December 2020

An overview on immunoregulatory and anti-inflammatory properties of chrysin and flavonoids substances

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12 December 2020

Anti-inflammatory effect of Crocus sativus on the serum cytokines levels in subjects with Metabolic Syndrome: A Randomized, Double-blind, Placebo - controlled trial.

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12 December 2020

A comprehensive review on anticancer mechanisms of the main carotenoid of saffron, crocin.

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12 December 2020

Protective effect of crocin on BPA-induced liver toxicity in rats through inhibition of oxidative stress and downregulation of MAPK and MAPKAP signaling pathway and miRNA-122 expression.

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12 December 2020

affron® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial.

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12 December 2020

Crocin modulates IL-4/IL-13 signaling and ameliorates experimentally induced allergic airway asthma in a murine model

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12 December 2020

miR-371, miR-138, miR-544, miR-145, and miR-214 could modulate Th1/Th2 balance in asthma through the combinatorial regulation of Runx3

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12 December 2020

Anti-oxidative effects of safranal on immobilization-induced oxidative damage in rat brain.

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12 December 2020

Neuroprotective effect of safranal, an active ingredient of Crocus sativus , in a rat model of transient cerebral ischemia

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12 December 2020

Innate Immunity and Neurodegeneration.

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12 December 2020

Crocus sativus L. aqueous extract reduces atherogenesis, increases atherosclerotic plaque stability and improves glucose control in diabetic atherosclerotic animals.

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12 December 2020

Pharmacokinetic Properties of Saffron and its Active Components.

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12 December 2020

Crocetin attenuates spared nerve injury-induced neuropathic pain in mice

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12 December 2020

Crocin alleviates coronary atherosclerosis via inhibiting lipid synthesis and inducing M2 macrophage polarization

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12 December 2020

Protective effect of crocin against d-galactose-induced aging in mice.

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12 December 2020

The effects of tramadol administration on hippocampal cell apoptosis, learning and memory in adult rats and neuroprotective effects of crocin.

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12 December 2020

Saffron petal as a new pharmacological target: a review

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12 December 2020

10.22038/IJBMS.2019.34365.8158

Identifiers

DOI

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30 June 2019

PMC publication ID

6535192

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30 June 2019

PubMed publication ID

31223464

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30 June 2019