(Q64907374)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30167520%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

title

Temporal Trends and Factors Associated With Cardiovascular Drug Development, 1990 to 2012 (English)

1 reference

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20 April 2020

4

1 reference

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20 April 2020

Julie C Lauffenburger

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30167520%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

author name string

Thomas J Hwang

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30167520%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

Jessica M Franklin

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30167520%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

publication date

29 August 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30167520%20AND%20SRC:MED&resulttype=core&format=json

JACC. Basic to Translational Science

20 April 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30167520%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

volume

1

1 reference

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20 April 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30167520%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

page(s)

301-308

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30167520%20AND%20SRC:MED&resulttype=core&format=json

Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. Main results of the GUARDIAN trial. Guard during ischemia against necrosis (GUARDIAN) Investigators

20 April 2020

cites work

1 reference

12 December 2020

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

1 reference

12 December 2020

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

1 reference

12 December 2020

Randomized, double-blind, placebo-controlled, international trial of the oral IIb/IIIa antagonist lotrafiban in coronary and cerebrovascular disease

1 reference

12 December 2020

Cardiovascular disease in non-Western countries

1 reference

12 December 2020

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

1 reference

12 December 2020

Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

1 reference

12 December 2020

Cardiovascular disease in the developing world and its cost-effective management

1 reference

12 December 2020

Estimating the cost of new drug development: is it really 802 million dollars?

1 reference

12 December 2020

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

1 reference

12 December 2020

Effects of torcetrapib in patients at high risk for coronary events

1 reference

12 December 2020

A randomised trial of a pre-synaptic stimulator of DA2-dopaminergic and alpha2-adrenergic receptors on morbidity and mortality in patients with heart failure

1 reference

12 December 2020

Drug-review deadlines and safety problems

1 reference

12 December 2020

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

1 reference

12 December 2020

An uncertain future for cardiovascular drug development?

1 reference

12 December 2020

The productivity crisis in pharmaceutical R&D.

1 reference

12 December 2020

Effect of a monoclonal antibody to PCSK9 on LDL cholesterol

1 reference

12 December 2020

Genetics: a gene of rare effect

1 reference

12 December 2020

An improved approach to measuring drug innovation finds steady rates of first-in-class pharmaceuticals, 1987-2011.

1 reference

12 December 2020

Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial

1 reference

12 December 2020

Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial

1 reference

12 December 2020

Regulatory watch: Where do new medicines originate from in the EU?

1 reference

12 December 2020

Target small firms for antibiotic innovation

1 reference

12 December 2020

Drug development and FDA approval, 1938-2013.

1 reference

12 December 2020

The discovery of first-in-class drugs: origins and evolution.

1 reference

12 December 2020

Global Burden of Cardiovascular Disease

1 reference

12 December 2020

Angiotensin-neprilysin inhibition versus enalapril in heart failure

1 reference

12 December 2020

Sharing and reporting the results of clinical trials

1 reference

12 December 2020

Accessibility of trial reports for drugs stalling in development: a systematic assessment of registered trials

1 reference

12 December 2020

Cardiovascular drug development: is it dead or just hibernating?

1 reference

12 December 2020

Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013

1 reference

12 December 2020

Trends in utilization of FDA expedited drug development and approval programs, 1987-2014: cohort study

1 reference

12 December 2020

A cholesterol-lowering VLP vaccine that targets PCSK9

1 reference

12 December 2020

Reducing LDL with PCSK9 Inhibitors--The Clinical Benefit of Lipid Drugs

1 reference

12 December 2020

Tribulations of Recent Cardiology Trials, the Audacity of Hope, and HOPE-3.

1 reference

12 December 2020

Two decades of new drug development for central nervous system disorders

1 reference

12 December 2020

Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association

1 reference

12 December 2020

Vaccine Pipeline Has Grown During The Past Two Decades With More Early-Stage Trials From Small And Medium-Size Companies

1 reference

12 December 2020

10.1016/J.JACBTS.2016.03.012

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30167520%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30167520%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

PubMed publication ID

30167520

1 reference