(Q48070614)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25033734%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

title

The discovery of first-in-class drugs: origins and evolution (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25033734%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25033734%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

author name string

Jörg Eder

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25033734%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

Richard Sedrani

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25033734%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

publication date

18 July 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25033734%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Drug Discovery

9 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25033734%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

volume

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25033734%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25033734%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

page(s)

577-587

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25033734%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrd4336

9 March 2020

exact match

0 references

cites work

The role of innovation in drug development

1 reference

The case for entrepreneurship in R&D in the pharmaceutical industry

31 March 2020

1 reference

Pharmaceutical R&D: the road to positive returns

31 March 2020

1 reference

How to improve R&D productivity: the pharmaceutical industry's grand challenge

31 March 2020

1 reference

Can the pharmaceutical industry reduce attrition rates?

31 March 2020

1 reference

Why has R&D productivity declined in the pharmaceutical industry?

31 March 2020

1 reference

Diagnosing the decline in pharmaceutical R&D efficiency

31 March 2020

1 reference

Lessons from 60 years of pharmaceutical innovation

31 March 2020

1 reference

Realism in drug discovery-could Cassandra be right?

31 March 2020

1 reference

The productivity crisis in pharmaceutical R&D.

31 March 2020

1 reference

How were new medicines discovered?

31 March 2020

1 reference

Can cell systems biology rescue drug discovery?

31 March 2020

1 reference

A critique of the molecular target-based drug discovery paradigm based on principles of metabolic control: advantages of pathway-based discovery

31 March 2020

1 reference

Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it.

31 March 2020

1 reference

Phenotypic screens as a renewed approach for drug discovery

31 March 2020

1 reference

Phenotypic vs. target-based drug discovery for first-in-class medicines

31 March 2020

1 reference

Impact of high-throughput screening in biomedical research

31 March 2020

1 reference

Strategies and challenges for the next generation of therapeutic antibodies

31 March 2020

1 reference

Transplacental carcinogenesis by stilbestrol

31 March 2020

1 reference

Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid

31 March 2020

1 reference

Vascular endothelial growth factor is a secreted angiogenic mitogen

31 March 2020

1 reference

Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining

31 March 2020

1 reference

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

31 March 2020

1 reference

2-Azetidinones as inhibitors of cholesterol absorption.

31 March 2020

1 reference

31 March 2020

1 reference

Forward chemical genetics: progress and obstacles on the path to a new pharmacopoeia

31 March 2020

1 reference

Chemoproteomics-driven drug discovery: addressing high attrition rates

31 March 2020

1 reference

Phenotypic screening strategies for neurodegenerative diseases: a pathway to discover novel drug candidates and potential disease targets or mechanisms

31 March 2020

1 reference

Forward chemical genetics in yeast for discovery of chemical probes targeting metabolism

31 March 2020

1 reference

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

31 March 2020

1 reference

Is poor research the cause of the declining productivity of the pharmaceutical industry? An industry in need of a paradigm shift

31 March 2020

1 reference

Neoclassic drug discovery: the case for lead generation using phenotypic and functional approaches

31 March 2020

1 reference

Combining imaging and pathway profiling: an alternative approach to cancer drug discovery

31 March 2020

1 reference

Modern phenotypic drug discovery is a viable, neoclassic pharma strategy

31 March 2020

1 reference

Back to the future: lessons learned in modern target-based and whole-cell lead optimization of antimalarials.

31 March 2020

1 reference

Drugs for bad bugs: confronting the challenges of antibacterial discovery

31 March 2020

1 reference

A new grammar for drug discovery

31 March 2020

1 reference

PTC124 targets genetic disorders caused by nonsense mutations

31 March 2020

1 reference

Spiroindolones, a potent compound class for the treatment of malaria

31 March 2020

1 reference

Effects of 2,4-diaminoquinazoline derivatives on SMN expression and phenotype in a mouse model for spinal muscular atrophy

31 March 2020

1 reference

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

31 March 2020

1 reference

Selective inhibition of BET bromodomains

31 March 2020

1 reference

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

31 March 2020

1 reference

Reporter gene technology: the future looks bright

31 March 2020

1 reference

Protein reporter bioassay systems for the phenotypic screening of candidate drugs: a mouse platform for anti-aging drug screening

31 March 2020

1 reference

Systems and integrative biology as alternative guises for pharmacology: prime time for an iPharm concept?

31 March 2020

1 reference

Antitumor activity of 3-ingenyl angelate: plasma membrane and mitochondrial disruption and necrotic cell death

31 March 2020

1 reference

Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation

31 March 2020

1 reference

Transport and phosphorylation as factors in the antitumor action of cytosine arabinoside

31 March 2020

1 reference

Deoxyguanosine toxicity in a mouse T lymphoma: Relationship to purine nucleoside phosphorylase-associated immune dysfunction

31 March 2020

1 reference

Antiviral activity of 1-docosanol, an inhibitor of lipid-enveloped viruses including herpes simplex

31 March 2020

1 reference

Flupirtine, a re-discovered drug, revisited

31 March 2020

1 reference

Rebuilding the R&D engine in big pharma

31 March 2020

1 reference

12 December 2020

Selective toxicity of deoxyguanosine and arabinosyl guanine for T-leukemic cells.

1 reference

12 December 2020

2-Amino-6-methoxypurine arabinoside: an agent for T-cell malignancies

1 reference

12 December 2020

Tumor angiogenesis: transfilter diffusion studies in the hamster by the transparent chamber technique

1 reference

12 December 2020

Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative.

1 reference

12 December 2020

From toxicological problem to therapeutic use: the discovery of the mode of action of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC), its toxicology and development as a drug

1 reference

12 December 2020

Tumor angiogenesis: therapeutic implications

1 reference

12 December 2020

Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD4336

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25033734%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference