(Q45352809)

13 December 2017

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title

Impact of high-throughput screening in biomedical research (English)

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13 December 2017

Dragan A Cirovic

5

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author name string

Ricardo Macarron

1

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13 December 2017

Martyn N Banks

2

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13 December 2017

Dejan Bojanic

3

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13 December 2017

David J Burns

4

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13 December 2017

Tina Garyantes

6

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13 December 2017

Darren V S Green

7

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13 December 2017

Robert P Hertzberg

8

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13 December 2017

William P Janzen

9

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13 December 2017

Jeff W Paslay

10

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13 December 2017

Ulrich Schopfer

11

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13 December 2017

G Sitta Sittampalam

12

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13 December 2017

publication date

1 March 2011

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Nature Reviews Drug Discovery

13 December 2017

published in

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13 December 2017

volume

10

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13 December 2017

issue

3

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13 December 2017

page(s)

188-195

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The Year's New Drugs & Biologics - 2009.

13 December 2017

cites work

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Drug repositioning: identifying and developing new uses for existing drugs

21 January 2018

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

21 January 2018

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An efficient method for the detection and elimination of systematic error in high-throughput screening

21 January 2018

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Process validation and screen reproducibility in high-throughput screening.

21 January 2018

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A standard operating procedure for assessing liquid handler performance in high-throughput screening

21 January 2018

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High-throughput screening: update on practices and success

21 January 2018

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Hit and lead generation: beyond high-throughput screening

21 January 2018

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Can the pharmaceutical industry reduce attrition rates?

21 January 2018

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An analysis of the binding efficiencies of drugs and their leads in successful drug discovery programs

21 January 2018

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Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity

21 January 2018

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Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis

21 January 2018

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Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 1. Discovery and optimization of salicylaldehyde thiosemicarbazone thrombopoietin mimics.

21 January 2018

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Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 2. Rational design of naphtho[1,2-d]imidazole thrombopoietin mimics

21 January 2018

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Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist.

21 January 2018

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Drug discovery in jeopardy

21 January 2018

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Identification of Hepatitis C Virus NS5A Inhibitors

21 January 2018

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Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

21 January 2018

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Is there a difference between leads and drugs? A historical perspective

21 January 2018

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Pursuing the leadlikeness concept in pharmaceutical research.

21 January 2018

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Key aspects of the Novartis compound collection enhancement project for the compilation of a comprehensive chemogenomics drug discovery screening collection

21 January 2018

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Defining and maintaining a high quality screening collection: the GSK experience

21 January 2018

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Enhancements of screening collections to address areas of unmet medical need: an industry perspective

21 January 2018

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21 January 2018

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Design of a compound screening collection for use in high throughput screening

21 January 2018

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Do structurally similar molecules have similar biological activity?

21 January 2018

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Lessons from 60 years of pharmaceutical innovation

21 January 2018

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The completed human genome: implications for chemical biology

21 January 2018

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Driving drug discovery: the fundamental role of academic labs.

21 January 2018

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The art of the chemical probe

21 January 2018

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Case study: impact of technology investment on lead discovery at Bristol-Myers Squibb, 1998-2006.

21 January 2018

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Application of division arrest technology to cell-based HTS: comparison with frozen and fresh cells

21 January 2018

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Evaluation of division-arrested cells for cell-based high-throughput screening and profiling

21 January 2018

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Evolution of cell-based reagent provision

21 January 2018

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Cryopreserved cells facilitate cell-based drug discovery

21 January 2018

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G-protein-coupled receptors in drug discovery: nanosizing using cell-free technologies and molecular biology approaches.

21 January 2018

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Confocal fluorescence microscopy for high-throughput screening of G-protein coupled receptors.

21 January 2018

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Fluorescence techniques: shedding light on ligand-receptor interactions

21 January 2018

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Current in vitro kinase assay technologies: the quest for a universal format

21 January 2018

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High-content analysis of kinase activity in cells

21 January 2018

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The A, B, Cs of G-protein-coupled receptor pharmacology in assay development for HTS.

21 January 2018

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G-protein coupled receptor assays: to measure affinity or efficacy that is the question

21 January 2018

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Functional cell-based assays in microliter volumes for ultra-high throughput screening

21 January 2018

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Cellular assays as portals to seven-transmembrane receptor-based drug discovery

21 January 2018

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A specific inhibitor of the epidermal growth factor receptor tyrosine kinase

21 January 2018

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Discovery and development of sorafenib: a multikinase inhibitor for treating cancer.

21 January 2018

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Structure-based design of HIV protease inhibitors: 4-hydroxycoumarins and 4-hydroxy-2-pyrones as non-peptidic inhibitors

21 January 2018

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Discovery of JANUVIA (Sitagliptin), a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

21 January 2018

1 reference

2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (d

21 January 2018

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Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists

21 January 2018

1 reference

From 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk](1,4)benzodiazepin-2(1H)-one (TIBO) to etravirine (TMC125): fifteen years of research on non-nucleoside inhibitors of HIV-1 reverse transcriptase

21 January 2018

1 reference

Who wants to be irrational?

21 January 2018

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How to improve R&D productivity: the pharmaceutical industry's grand challenge

31 March 2020

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The influence of lead discovery strategies on the properties of drug candidates

31 March 2020

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Molecular biology. Industrial-style screening meets academic biology

31 March 2020

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OPC-21268, an Orally Effective, Nonpeptide Vasopressin V1 Receptor Antagonist

31 March 2020

1 reference

Rebuilding the R&D engine in big pharma

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21358738

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Overcoming the obstacles in the pharma/biotech industry: 2009 update

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21358738

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRD3368

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Dimensions Publication ID

13 December 2017

1041527430

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