(Q83398483)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19247303%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

review article

1 reference

title

The influence of lead discovery strategies on the properties of drug candidates (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19247303%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19247303%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

author name string

Gergely M Makara

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19247303%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

publication date

1 March 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19247303%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Drug Discovery

22 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19247303%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

volume

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19247303%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19247303%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

page(s)

203-212

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19247303%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrd2796

22 January 2020

exact match

0 references

cites work

How can we avoid the productivity gap?

1 reference

Hit discovery and hit-to-lead approaches

31 March 2020

1 reference

Components of successful lead generation

31 March 2020

1 reference

Drugs, leads, and drug-likeness: an analysis of some recently launched drugs

31 March 2020

1 reference

Molecular complexity and its impact on the probability of finding leads for drug discovery

31 March 2020

1 reference

Pursuing the leadlikeness concept in pharmaceutical research.

31 March 2020

1 reference

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

31 March 2020

1 reference

The influence of target family and functional activity on the physicochemical properties of pre-clinical compounds

31 March 2020

1 reference

The influence of drug-like concepts on decision-making in medicinal chemistry

31 March 2020

1 reference

High-throughput screening: update on practices and success

31 March 2020

1 reference

High-throughput screening: searching for higher productivity

31 March 2020

1 reference

Critical review of the role of HTS in drug discovery

31 March 2020

1 reference

Design of a compound screening collection for use in high throughput screening

31 March 2020

1 reference

High Throughput Screening for Drug Discovery: Continually Transitioning into New Technology

31 March 2020

1 reference

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

31 March 2020

1 reference

"Plate cherry picking": a novel semi-sequential screening paradigm for cheaper, faster, information-rich compound selection.

31 March 2020

1 reference

Biological assay challenges from compound solubility: strategies for bioassay optimization

31 March 2020

1 reference

Functional group contributions to drug-receptor interactions.

31 March 2020

1 reference

Molecular properties that influence the oral bioavailability of drug candidates

31 March 2020

1 reference

A ‘Rule of Three’ for fragment-based lead discovery?

31 March 2020

1 reference

Ligand efficiency: a useful metric for lead selection

31 March 2020

1 reference

Lead compounds discovered from libraries: part 2.

31 March 2020

1 reference

Fragment-based lead discovery

31 March 2020

1 reference

Fragment-based drug discovery: what has it achieved so far?

31 March 2020

1 reference

Natural products as a screening resource

31 March 2020

1 reference

Virtual screening strategies in drug discovery

31 March 2020

1 reference

Drug-like properties and the causes of poor solubility and poor permeability

31 March 2020

1 reference

Is there a difference between leads and drugs? A historical perspective

31 March 2020

1 reference

Lead-like, drug-like or "Pub-like": how different are they?

31 March 2020

1 reference

Thiophene substituted acylguanidines as BACE1 inhibitors

31 March 2020

1 reference

Identification of a small molecule nonpeptide active site beta-secretase inhibitor that displays a nontraditional binding mode for aspartyl proteases

31 March 2020

1 reference

Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase

31 March 2020

1 reference

Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency

31 March 2020

1 reference

Tyramine fragment binding to BACE-1

31 March 2020

1 reference

Ligand binding efficiency: trends, physical basis, and implications

31 March 2020

1 reference

Recent developments in fragment-based drug discovery

31 March 2020

1 reference

Progress toward the discovery and development of efficacious BACE inhibitors

31 March 2020

1 reference

12 December 2020

NMR-based approaches for lead discovery.

1 reference

12 December 2020

Improving success rates for lead generation using affinity binding technologies

1 reference

12 December 2020

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

12 December 2020

Hit and Lead identification: efficient practices for drug discovery

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD2796

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19247303%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference