(Q64943206)

1 July 2019

title

Hydroxynorketamine: Implications for the NMDA Receptor Hypothesis of Ketamine's Antidepressant Action. (English)

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1 July 2019

author name string

Lily R Aleksandrova

series ordinal

1

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1 July 2019

Yu Tian Wang

series ordinal

2

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1 July 2019

Anthony G Phillips

series ordinal

3

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1 July 2019

publication date

1 January 2017

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1 July 2019

published in

Chronic Stress

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1 July 2019

volume

1

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1 July 2019

Trapping channel block of NMDA-activated responses by amantadine and memantine

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Signaling pathways underlying the rapid antidepressant actions of ketamine

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GluN2B-containing NMDA receptors as possible targets for the neuroprotective and antidepressant effects of fluoxetine

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Simultaneous population pharmacokinetic modelling of ketamine and three major metabolites in patients with treatment-resistant bipolar depression

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Antidepressant-like effects of low ketamine dose is associated with increased hippocampal AMPA/NMDA receptor density ratio in female Wistar-Kyoto rats

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Stress, anxiety, and dendritic spines: what are the connections?

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Acute administration of ketamine in rats increases hippocampal BDNF and mTOR levels during forced swimming test

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Sub-anesthetic concentrations of (R,S)-ketamine metabolites inhibit acetylcholine-evoked currents in α7 nicotinic acetylcholine receptors.

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Sex differences in the antidepressant-like effects of ketamine

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Pharmacological blockade of GluN2B-containing NMDA receptors induces antidepressant-like effects lacking psychotomimetic action and neurotoxicity in the perinatal and adult rodent brain.

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Does increasing the ratio of AMPA-to-NMDA receptor mediated neurotransmission engender antidepressant action? Studies in the mouse forced swim and tail suspension tests

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Nicotinic acetylcholine receptor antagonists alter the function and expression of serine racemase in PC-12 and 1321N1 cells

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Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex

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Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants

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The role of GluN2A and GluN2B subunits on the effects of NMDA receptor antagonists in modeling schizophrenia and treating refractory depression

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(R,S)-Ketamine metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine increase the mammalian target of rapamycin function.

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12 December 2020

D-serine plasma concentration is a potential biomarker of (R,S)-ketamine antidepressant response in subjects with treatment-resistant depression

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Ketamine: promising path or false prophecy in the development of novel therapeutics for mood disorders?

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GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine

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Ketamine and rapid-acting antidepressants: a window into a new neurobiology for mood disorder therapeutics

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Enhancing AMPA to NMDA throughput as a convergent mechanism for antidepressant action

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Sex differences in the rapid and the sustained antidepressant-like effects of ketamine in stress-naïve and "depressed" mice exposed to chronic mild stress

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The role of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in depression: central mediators of pathophysiology and antidepressant activity?

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Two cellular hypotheses explaining the initiation of ketamine's antidepressant actions: Direct inhibition and disinhibition.

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R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects

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BDNF - a key transducer of antidepressant effects.

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Activation of a ventral hippocampus-medial prefrontal cortex pathway is both necessary and sufficient for an antidepressant response to ketamine

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Single-dose infusion ketamine and non-ketamine N-methyl-d-aspartate receptor antagonists for unipolar and bipolar depression: a meta-analysis of efficacy, safety and time trajectories

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Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

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12 December 2020

Subchronic administration of (R,S)-ketamine induces ketamine ring hydroxylation in Wistar rats.

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Ketamine for treatment-resistant depression: recent developments and clinical applications

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KETAMINE'S MECHANISM OF ACTION: A PATH TO RAPID-ACTING ANTIDEPRESSANTS.

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Ketamine Metabolites Enantioselectively Decrease Intracellular D-Serine Concentrations in PC-12 Cells

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NMDAR inhibition-independent antidepressant actions of ketamine metabolites.

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Ketamine enantiomers in the rapid and sustained antidepressant effects

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12 December 2020

Effects of Ketamine and Ketamine Metabolites on Evoked Striatal Dopamine Release, Dopamine Receptors, and Monoamine Transporters.

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Effects of a single bilateral infusion of R-ketamine in the rat brain regions of a learned helplessness model of depression

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Ketamine's antidepressant action: beyond NMDA receptor inhibition

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Ketamine: NMDA Receptors and Beyond.

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12 December 2020

Antidepressant Actions of Ketamine Versus Hydroxynorketamine

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12 December 2020

Reply to: Antidepressant Actions of Ketamine Versus Hydroxynorketamine

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12 December 2020

Ketamine: 50 Years of Modulating the Mind

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12 December 2020

(R)-Ketamine Shows Greater Potency and Longer Lasting Antidepressant Effects Than Its Metabolite (2R,6R)-Hydroxynorketamine.

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12 December 2020

What is the mechanism of Ketamine's rapid-onset antidepressant effect? A concise overview of the surprisingly large number of possibilities.

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12 December 2020

Antidepressant Potential of (R)-Ketamine in Rodent Models: Comparison with (S)-Ketamine.

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12 December 2020

Antidepressant effects of ketamine and the roles of AMPA glutamate receptors and other mechanisms beyond NMDA receptor antagonism

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12 December 2020

Quantitative chiral and achiral determination of ketamine and its metabolites by LC-MS/MS in human serum, urine and fecal samples

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12 December 2020

What's the Buzz About Hydroxynorketamine? Is It the History, the Story, the Debate, or the Promise?

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12 December 2020

Effects of a ketamine metabolite on synaptic NMDAR function.

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12 December 2020

Identifiers

DOI

10.1177/2470547017743511

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1 July 2019

PMC publication ID

6292673

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1 July 2019

PubMed publication ID

30556028

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1 July 2019