(Q64975224)

English

Pharmacogenomics of codeine, morphine, and morphine-6-glucuronide: model-based analysis of the influence of CYP2D6 activity, UGT2B7 activity, renal impairment, and CYP3A4 inhibition.

scientific article published in February 2012

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

2 July 2019

http://europepmc.org/abstract/MED/22352453

Pharmacogenomics of codeine, morphine, and morphine-6-glucuronide: model-based analysis of the influence of CYP2D6 activity, UGT2B7 activity, renal impairment, and CYP3A4 inhibition. (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 July 2019

http://europepmc.org/abstract/MED/22352453

pharmacogenomics

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Thomas Eissing

1

1 reference

Europe PubMed Central

PubMed publication ID

2 July 2019

http://europepmc.org/abstract/MED/22352453

Jörg Lippert

2

1 reference

Europe PubMed Central

PubMed publication ID

2 July 2019

http://europepmc.org/abstract/MED/22352453

Stefan Willmann

3

1 reference

Europe PubMed Central

PubMed publication ID

2 July 2019

http://europepmc.org/abstract/MED/22352453

publication date

1 February 2012

1 reference

Europe PubMed Central

PubMed publication ID

2 July 2019

http://europepmc.org/abstract/MED/22352453

Molecular Diagnosis and Therapy

1 reference

Europe PubMed Central

PubMed publication ID

2 July 2019

http://europepmc.org/abstract/MED/22352453

16

1 reference

Europe PubMed Central

PubMed publication ID

2 July 2019

http://europepmc.org/abstract/MED/22352453

1

1 reference

Europe PubMed Central

PubMed publication ID

2 July 2019

http://europepmc.org/abstract/MED/22352453

43-53

1 reference

Europe PubMed Central

PubMed publication ID

2 July 2019

http://europepmc.org/abstract/MED/22352453

Codeine, ultrarapid-metabolism genotype, and postoperative death

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Codeine intoxication in the neonate

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of morphine in patients with renal failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro-in vivo extrapolation predicts drug-drug interactions arising from inhibition of codeine glucuronidation by dextropropoxyphene, fluconazole, ketoconazole, and methadone in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The analgesic activity of morphine-6-glucuronide

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characteristic glucuronidation pattern of physiologic concentration of morphine in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Codeine intoxication associated with ultrarapid CYP2D6 metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy and safety of morphine-6-glucuronide (M6G) for postoperative pain relief: a randomized, double-blind study

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of single-dose i.v. morphine in normal volunteers and patients with end-stage renal failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of UDP-glucuronosyltransferase 1A1 and 1A8 to morphine-6-glucuronidation and its kinetic properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Patient-controlled analgesia (PCA) with codeine for postoperative pain relief in ten extensive metabolisers and one poor metaboliser of dextromethorphan

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectives

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Can extremely low or high morphine formation from codeine be predicted prior to therapy initiation?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacogenetic determination of the effects of codeine and prediction of drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A case of probable codeine poisoning in a young infant after the use of a proprietary cough and cold medicine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apnea in a child after oral codeine: a genetic variant - an ultra-rapid metabolizer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatal and severe codeine intoxication in 3-year-old twins--interpretation of drug and metabolite concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety of codeine during breastfeeding: fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Risk to the breast-fed neonate from codeine treatment to the mother: a quantitative mechanistic modeling study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphine-6-glucuronide disposition in renal impairment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A pharmacogenetic study of uridine diphosphate-glucuronosyltransferase 2B7 in patients receiving morphine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of environmental and genetic factors on codeine analgesia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CYP3A4 drug interactions: correlation of 10 in vitro probe substrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interindividual variability in pharmacokinetics of generic nucleoside reverse transcriptase inhibitors in TB/HIV-coinfected ghanaian patients: UGT2B7*1c is associated with faster zidovudine clearance and glucuronidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

O-demethylation of codeine to morphine inhibited by low-dose levomepromazine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Codeine and morphine in extensive and poor metabolizers of sparteine: pharmacokinetics, analgesic effect and side effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Renal failure does not impair the metabolism of morphine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of a physiology-based whole-body population model for assessing the influence of individual variability on the pharmacokinetics of drugs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug dosing error with drops: severe clinical course of codeine intoxication in twins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma concentrations of codeine and its metabolite, morphine, after single and repeated oral administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Are poor metabolisers of sparteine/debrisoquine less pain tolerant than extensive metabolisers?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacogenetic determinants of codeine induction by rifampin: the impact on codeine's respiratory, psychomotor and miotic effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantification of the O- and N-demethylated and the glucuronidated metabolites of codeine relative to the debrisoquine metabolic ratio in urine in ultrarapid, rapid, and poor debrisoquine hydroxylators

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serious morbidity associated with misuse of over-the-counter codeine-ibuprofen analgesics: a series of 27 cases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacogenetics of codeine hypoalgesia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacogenetic insights into codeine analgesia: implications to pediatric codeine use.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models

1 reference

https://pubmed.ncbi.nlm.nih.gov/22352453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 July 2019

http://europepmc.org/abstract/MED/22352453

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