(Q66499217)

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17 August 2019

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30 April 2020

title

Structure elucidation of colibactin and its DNA cross-links (English)

2 references

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17 August 2019

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30 April 2020

0 references

2

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17 August 2019

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30 April 2020

Alan R Healy

3

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17 August 2019

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30 April 2020

Zhixun Wang

5

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17 August 2019

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30 April 2020

Mengzhao Xue

1

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30 April 2020

Kevin M Wernke

4

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30 April 2020

Madeline C Frischling

6

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30 April 2020

Emilee Shine

7

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30 April 2020

Weiwei Wang

8

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30 April 2020

Seth B. Herzon

9

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30 April 2020

Jason M Crawford

10

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30 April 2020

author name string

Mengzhao Xue

1

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17 August 2019

Kevin M. Wernke

4

1 reference

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17 August 2019

Madeline C. Frischling

6

1 reference

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17 August 2019

Emilee E. Shine

7

1 reference

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17 August 2019

Weiwei Wang

8

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17 August 2019

Seth B. Herzon

9

1 reference

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17 August 2019

Jason M. Crawford

10

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language of work or name

English

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publication date

8 August 2019

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30 April 2020

2 references

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17 August 2019

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30 April 2020

volume

365

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30 April 2020

page(s)

eaax2685

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17 August 2019

issue

6457

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Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection

30 April 2020

cites work

1 reference

12 December 2020

Escherichia coli induces DNA double-strand breaks in eukaryotic cells.

1 reference

12 December 2020

Molecular epidemiology and phylogenetic distribution of the Escherichia coli pks genomic island

1 reference

12 December 2020

Genetic structure and distribution of the colibactin genomic island among members of the family Enterobacteriaceae.

1 reference

12 December 2020

Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells

1 reference

12 December 2020

ClbP is a prototype of a peptidase subgroup involved in biosynthesis of nonribosomal peptides

1 reference

12 December 2020

Intestinal inflammation targets cancer-inducing activity of the microbiota.

1 reference

12 December 2020

Analysis of structure-function relationships in the colibactin-maturating enzyme ClbP

1 reference

12 December 2020

A prodrug resistance mechanism is involved in colibactin biosynthesis and cytotoxicity

1 reference

12 December 2020

High prevalence of mucosa-associated E. coli producing cyclomodulin and genotoxin in colon cancer

1 reference

12 December 2020

In vivo evidence for a prodrug activation mechanism during colibactin maturation.

1 reference

12 December 2020

Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype.

1 reference

12 December 2020

Comparative metabolomics and structural characterizations illuminate colibactin pathway-dependent small molecules.

1 reference

12 December 2020

Isolation of a metabolite from the pks island provides insights into colibactin biosynthesis and activity.

1 reference

12 December 2020

The colibactin warhead crosslinks DNA.

1 reference

12 December 2020

Critical Intermediates Reveal New Biosynthetic Events in the Enigmatic Colibactin Pathway

1 reference

12 December 2020

Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursor

1 reference

12 December 2020

Colibactin: understanding an elusive gut bacterial genotoxin

1 reference

12 December 2020

Linking Biosynthetic Gene Clusters to their Metabolites via Pathway- Targeted Molecular Networking

1 reference

12 December 2020

Escherichia coli ClbS is a colibactin resistance protein.

1 reference

12 December 2020

Characterization of Polyketide Synthase Machinery from the pks Island Facilitates Isolation of a Candidate Precolibactin.

1 reference

12 December 2020

Convergent and Modular Synthesis of Candidate Precolibactins. Structural Revision of Precolibactin A.

1 reference

12 December 2020

The Enterobacterial Genotoxins: Cytolethal Distending Toxin and Colibactin

1 reference

12 December 2020

Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin

1 reference

12 December 2020

A Mechanistic Model for Colibactin-Induced Genotoxicity.

1 reference

12 December 2020

Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis.

1 reference

12 December 2020

Locoregional Effects of Microbiota in a Preclinical Model of Colon Carcinogenesis.

1 reference

12 December 2020

Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety

1 reference

12 December 2020

Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring.

1 reference

12 December 2020

Structure and Functional Analysis of ClbQ, an Unusual Intermediate-Releasing Thioesterase from the Colibactin Biosynthetic Pathway

1 reference

12 December 2020

Molecular Basis of Gut Microbiome-Associated Colorectal Cancer: A Synthetic Perspective.

1 reference

12 December 2020

ClbS Is a Cyclopropane Hydrolase That Confers Colibactin Resistance.

1 reference

12 December 2020

Moving beyond microbiome-wide associations to causal microbe identification

1 reference

12 December 2020

The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells.

1 reference

12 December 2020

Colibactin: More Than a New Bacterial Toxin.

1 reference

12 December 2020

Microbiome: Focus on Causation and Mechanism

1 reference

12 December 2020

Characterization of Natural Colibactin-Nucleobase Adducts by Tandem Mass Spectrometry and Isotopic Labeling. Support for DNA Alkylation by Cyclopropane Ring Opening

1 reference

12 December 2020

Model colibactins exhibit human cell genotoxicity in the absence of host bacteria

1 reference

12 December 2020

The human gut bacterial genotoxin colibactin alkylates DNA

1 reference

12 December 2020

Reactivity of an Unusual Amidase May Explain Colibactin's DNA Cross-Linking Activity

1 reference

12 December 2020

Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage

1 reference

12 December 2020

Synthesis and reactivity of precolibactin 886

1 reference

12 December 2020

Identifiers

2 references

https://api.crossref.org/v1/works/http://dx.doi.org/10.1126/science.aax2685

17 August 2019

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30 April 2020

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30 April 2020

1 reference