(Q86596654)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30765538%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

title

The human gut bacterial genotoxin colibactin alkylates DNA (English)

2 references

28 February 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30765538%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

0 references

0 references

0 references

Peter W. Villalta

3

2 references

28 February 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30765538%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

Alessia Stornetta

4

2 references

28 February 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30765538%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

Caitlin A. Brennan

7

2 references

28 February 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30765538%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

Silvia Balbo

13

2 references

28 February 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30765538%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

12

Wendy S. Garrett

2 references

28 February 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30765538%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

1

Matthew R. Wilson

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30765538%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

28 February 2020

2

Yindi Jiang

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30765538%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

28 February 2020

5

Paul D. Boudreau

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30765538%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

28 February 2020

6

Andrea Carrá

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30765538%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

28 February 2020

8

Eunyoung Chun

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30765538%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

28 February 2020

9

Lizzie Ngo

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30765538%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

28 February 2020

10

Leona D. Samson

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30765538%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

28 February 2020

11

Bevin P. Engelward

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30765538%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

28 February 2020

14

Emily P. Balskus

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30765538%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

28 February 2020

language of work or name

1 reference

28 February 2020

14 February 2019

1 reference

Crossref

28 February 2020

1 February 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30765538%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

2 references

28 February 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30765538%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

volume

363

2 references

28 February 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30765538%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

issue

6428

2 references

28 February 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30765538%20AND%20SRC:MED&resulttype=core&format=json

Characterization of Natural Colibactin-Nucleobase Adducts by Tandem Mass Spectrometry and Isotopic Labeling. Support for DNA Alkylation by Cyclopropane Ring Opening

23 April 2020

page(s)

eaar7785

1 reference

28 February 2020

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

E. coli and colorectal cancer: a complex relationship that deserves a critical mindset

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

ClbS Is a Cyclopropane Hydrolase That Confers Colibactin Resistance.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Cancer associated faecal microbial markers in colorectal cancer detection

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

The Human Intestinal Microbiome in Health and Disease

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

A Mechanistic Model for Colibactin-Induced Genotoxicity.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Convergent and Modular Synthesis of Candidate Precolibactins. Structural Revision of Precolibactin A.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Characterization of Polyketide Synthase Machinery from the pks Island Facilitates Isolation of a Candidate Precolibactin.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Escherichia coli ClbS is a colibactin resistance protein.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Screening for DNA Alkylation Mono and Cross-Linked Adducts with a Comprehensive LC-MS(3) Adductomic Approach

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Critical Intermediates Reveal New Biosynthetic Events in the Enigmatic Colibactin Pathway

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

The colibactin warhead crosslinks DNA.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Isolation of a metabolite from the pks island provides insights into colibactin biosynthesis and activity.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Micropatterned comet assay enables high throughput and sensitive DNA damage quantification

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Microbial genomic analysis reveals the essential role of inflammation in bacteria-induced colorectal cancer

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Comparative metabolomics and structural characterizations illuminate colibactin pathway-dependent small molecules.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

1H and 13C NMR scaling factors for the calculation of chemical shifts in commonly used solvents using density functional theory

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Application of a high-resolution mass-spectrometry-based DNA adductomics approach for identification of DNA adducts in complex mixtures.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

In vivo evidence for a prodrug activation mechanism during colibactin maturation.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

High prevalence of mucosa-associated E. coli producing cyclomodulin and genotoxin in colon cancer

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

A prodrug resistance mechanism is involved in colibactin biosynthesis and cytotoxicity

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Quantification of acylfulvene- and illudin S-DNA adducts in cells with variable bioactivation capacities.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Intestinal inflammation targets cancer-inducing activity of the microbiota.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Chemistry and biology of acylfulvenes: sesquiterpene-derived antitumor agents.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Balancing repair and tolerance of DNA damage caused by alkylating agents

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

ClbP is a prototype of a peptidase subgroup involved in biosynthesis of nonribosomal peptides

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Assigning stereochemistry to single diastereoisomers by GIAO NMR calculation: the DP4 probability

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Single cell trapping and DNA damage analysis using microwell arrays

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Chemical and biological explorations of the family of CC-1065 and the duocarmycin natural products.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Genomic and epigenetic instability in colorectal cancer pathogenesis

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Kinetics of H2AX phosphorylation after exposure to cisplatin

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Escherichia coli induces DNA double-strand breaks in eukaryotic cells.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Prokaryotic nucleotide excision repair: the UvrABC system.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

Chemical-induced DNA damage and human cancer risk

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6407708

23 February 2021

Identifiers

DOI

10.1126/SCIENCE.AAR7785

2 references

28 February 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30765538%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30765538%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

PubMed publication ID

30765538

1 reference