Wikidata

(Q6717778)

English

MutS homolog 2

mammalian protein found in Homo sapiens

  • DNA mismatch repair protein Msh2
  • MSH2
  • MutS protein homolog 2
  • DNA mismatch repair protein Msh2 transcript
  • mutS homolog 2, colon cancer, nonpolyposis type 1
  • hMSH2
  • MutS Homolog 2 Protein
In more languages

Statements

molecular function
protein binding
determination method
IPI
18 references
retrieved
9 May 2019
stated in
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair
GOA
curator
UniProt
UniProt protein ID
P43246
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
retrieved
9 May 2019
stated in
Histone deacetylase 10 regulates DNA mismatch repair and may involve the deacetylation of MutS homolog 2.
GOA
curator
UniProt
UniProt protein ID
P43246
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
retrieved
9 May 2019
stated in
MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation
GOA
curator
UniProt
UniProt protein ID
P43246
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
retrieved
9 May 2019
stated in
The novel protein complex with SMARCAD1/KIAA1122 binds to the vicinity of TSS
GOA
curator
UniProt
UniProt protein ID
P43246
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
retrieved
9 May 2019
stated in
Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
retrieved
9 May 2019
stated in
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
retrieved
9 May 2019
stated in
The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
retrieved
9 May 2019
stated in
(CAG)(n)-hairpin DNA binds to Msh2-Msh3 and changes properties of mismatch recognition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
retrieved
9 May 2019
stated in
Evidence for involvement of HMGB1 protein in human DNA mismatch repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
retrieved
9 May 2019
stated in
Identification of factors interacting with hMSH2 in the fetal liver utilizing the yeast two-hybrid system. In vivo interaction through the C-terminal domains of hEXO1 and hMSH2 and comparative expression analysis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
retrieved
9 May 2019
stated in
Interactions of human hMSH2 with hMSH3 and hMSH2 with hMSH6: examination of mutations found in hereditary nonpolyposis colorectal cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
retrieved
9 May 2019
stated in
Mechanism of mismatch recognition revealed by human MutSβ bound to unpaired DNA loops
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
retrieved
9 May 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
retrieved
9 May 2019
stated in
Functional alterations of human exonuclease 1 mutants identified in atypical hereditary nonpolyposis colorectal cancer syndrome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
retrieved
9 May 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
retrieved
9 May 2019
stated in
The nucleotide binding dynamics of human MSH2-MSH3 are lesion dependent
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
retrieved
9 May 2019
stated in
Analysis of the human MutLalpha.MutSalpha complex
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
retrieved
9 May 2019
stated in
hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
enzyme binding
determination method
IPI
8 references
retrieved
9 May 2019
stated in
Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors
GOA
curator
UniProt
UniProt protein ID
P43246
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
retrieved
9 May 2019
stated in
Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA
GOA
curator
UniProt
UniProt protein ID
P43246
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
retrieved
9 May 2019
stated in
MCM9 Is Required for Mammalian DNA Mismatch Repair.
GOA
curator
UniProt
UniProt protein ID
P43246
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
retrieved
9 May 2019
stated in
Human exonuclease I interacts with the mismatch repair protein hMSH2
GOA
curator
UniProt
UniProt protein ID
P43246
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
retrieved
9 May 2019
stated in
The interaction of DNA mismatch repair proteins with human exonuclease I
GOA
curator
UniProt
UniProt protein ID
P43246
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
retrieved
9 May 2019
stated in
Identification of factors interacting with hMSH2 in the fetal liver utilizing the yeast two-hybrid system. In vivo interaction through the C-terminal domains of hEXO1 and hMSH2 and comparative expression analysis
GOA
curator
UniProt
UniProt protein ID
P43246
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
retrieved
9 May 2019
stated in
HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexes
GOA
curator
UniProt
UniProt protein ID
P43246
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
retrieved
9 May 2019
stated in
Functional alterations of human exonuclease 1 mutants identified in atypical hereditary nonpolyposis colorectal cancer syndrome
GOA
curator
UniProt
UniProt protein ID
P43246
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IPI
mismatched DNA binding
determination method
IBA
IDA
IEA
6 references
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IEA
retrieved
9 May 2019
stated in
hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IDA
retrieved
9 May 2019
stated in
Human MutY homolog, a DNA glycosylase involved in base excision repair, physically and functionally interacts with mismatch repair proteins human MutS homolog 2/human MutS homolog 6
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IDA
retrieved
9 May 2019
stated in
Activation of human MutS homologs by 8-oxo-guanine DNA damage
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IBA
cell component
biological process
DNA mismatch repair
determination method
IDA
IGI
IEA
TAS
6 references
retrieved
17 October 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43246&geneProductId=UniProtKB:P43246
determination method
TAS
retrieved
17 October 2017
stated in
Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43246&geneProductId=UniProtKB:P43246
determination method
IGI
retrieved
17 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43246&geneProductId=UniProtKB:P43246
determination method
IEA
retrieved
17 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43246&geneProductId=UniProtKB:P43246
determination method
IEA
retrieved
17 October 2017
stated in
Purified human MSH2 protein binds to DNA containing mismatched nucleotides
GOA
curator
UniProt
UniProt protein ID
P43246
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43246&geneProductId=UniProtKB:P43246
determination method
IDA
retrieved
17 October 2017
stated in
Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiae
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43246&geneProductId=UniProtKB:P43246
determination method
IDA
DNA mismatch repair
determination method
IBA
IDA
IEA
IGI
TAS
7 references
retrieved
9 May 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
TAS
retrieved
9 May 2019
stated in
Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IGI
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IEA
retrieved
9 May 2019
stated in
Purified human MSH2 protein binds to DNA containing mismatched nucleotides
GOA
curator
UniProt
UniProt protein ID
P43246
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IDA
retrieved
9 May 2019
stated in
Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiae
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246
determination method
IBA
Gene Atlas image
PBB GE MSH2 209421 at fs.png
732 × 530; 12 KB
0 references

Identifiers

MeSH descriptor ID
D051718
subject named as
MutS Homolog 2 Protein
0 references
 
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