(Q67583915)

English

The enantiomers of the valproic acid analogue 2-n-propyl-4-pentynoic acid (4-yn-VPA): asymmetric synthesis and highly stereoselective teratogenicity in mice

scientific article published on 01 July 1992

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1437995%20AND%20SRC:MED&resulttype=core&format=json

15 September 2019

The enantiomers of the valproic acid analogue 2-n-propyl-4-pentynoic acid (4-yn-VPA): asymmetric synthesis and highly stereoselective teratogenicity in mice (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1437995%20AND%20SRC:MED&resulttype=core&format=json

15 September 2019

stereoselectivity

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

R. S. Hauck

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1437995

26 September 2022

H. Nau

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1437995

26 September 2022

language of work or name

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1437995

26 September 2022

publication date

1 July 1992

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1437995%20AND%20SRC:MED&resulttype=core&format=json

15 September 2019

Pharmaceutical Research

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1437995%20AND%20SRC:MED&resulttype=core&format=json

15 September 2019

9

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1437995%20AND%20SRC:MED&resulttype=core&format=json

15 September 2019

7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1437995%20AND%20SRC:MED&resulttype=core&format=json

15 September 2019

850-855

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1437995%20AND%20SRC:MED&resulttype=core&format=json

15 September 2019

Transfer of valproic acid and its main active unsaturated metabolite to the gestational tissue: correlation with neural tube defect formation in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproic acid and spina bifida

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fetal growth, major malformations, and minor anomalies in infants born to women receiving valproic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproic acid teratogenicity in mice after various administration and phenobarbital-pretreatment regimens: the parent drug and not one of the metabolites assayed is implicated as teratogen

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Asymmetric synthesis and teratogenic activity of (R)- and (S)-2-ethylhexanoic acid, a metabolite of the plasticizer di-(2-ethylhexyl)phthalate

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the development of alternative antiepileptic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproic acid and its metabolites: placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in neonates of epileptic mothers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproic acid-induced neural tube defects: reduction by folinic acid in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Asymmetric synthesis and enantioselective teratogenicity of 2-n-propyl-4-pentenoic acid (4-en-VPA), an active metabolite of the anticonvulsant drug, valproic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Structural bases of the teratogenic effects of the antiepileptic valproic acid. 2-n-propyl-4-pentenic acid, the first structural analogue with significantly higher teratogenic action than VPA].

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Teratogenic valproic acid concentrations: infusion by implanted minipumps vs conventional injection regimen in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible teratogenic effect of valproate during pregnancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacologic evaluation of various metabolites and analogs of valproic acid: teratogenic potencies in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproic Acid-Induced Neural Tube Defects in Mouse and Human: Aspects of Chirality, Alternative Drug Development, Pharmacokinetics and Possible Mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The enantioselective teratogenicity of 2-n-propyl-4-pentynoic acid (4-yn-VPA) is due to stereoselective intrinsic activity and not differences in pharmacokinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enantioselective synthesis and preliminary metabolic studies of the optical isomers of 2-n-propyl-4-pentenoic acid, a hepatotoxic metabolite of valproic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproate and birth defects

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new model for embryotoxicity testing: teratogenicity and pharmacokinetics of valproic acid following constant-rate administration in the mouse using human therapeutic drug and metabolite concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optical isomerism and pharmacological action, a generalization

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spina bifida and in-utero exposure to valproate

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maternal valproic acid and congenital neural tube defects

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In-utero exposure to valproate and neural tube defects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simplified method of evaluating dose-effect experiments

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A note on a simple apparatus for detecting neurological deficit in rats and mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1023/A:1015832411981

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1437995%20AND%20SRC:MED&resulttype=core&format=json

15 September 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1437995%20AND%20SRC:MED&resulttype=core&format=json

15 September 2019

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