(Q699997)

Cystine-knot cytokine

1 reference

Transforming growth factor-beta, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

TGF-beta, propeptide family

1 reference

based on heuristic

inferred from protein domain or family

Transforming growth factor beta, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

signaling receptor binding

1 reference

1 January 2018

Recombinant human bone morphogenetic protein induces bone formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

phosphatase activator activity

TAS

1 reference

1 January 2018

Effect of rhBMP-2 on the osteogenic potential of bone marrow stromal cells from an osteogenesis imperfecta mouse (oim)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4

growth factor activity

2 references

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

15 references

1 January 2018

Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Agrin binds BMP2, BMP4 and TGFbeta1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Targeting of bone morphogenetic protein growth factor complexes to fibrillin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

DIP2 disco-interacting protein 2 homolog A (Drosophila) is a candidate receptor for follistatin-related protein/follistatin-like 1--analysis of their binding with TGF-β superfamily proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Molecular recognition of BMP-2 and BMP receptor IA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Structure of the ternary signaling complex of a TGF-beta superfamily member

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Neogenin interacts with hemojuvelin through its two membrane-proximal fibronectin type III domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Crystal structure of the BMP-2-BRIA ectodomain complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 reference

1 January 2018

Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

protein heterodimerization activity

1 reference

1 January 2018

A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

transforming growth factor beta receptor binding

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

2 references

1 reference

1 January 2018

Bone marrow-derived heparan sulfate potentiates the osteogenic activity of bone morphogenetic protein-2 (BMP-2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 reference

1 January 2018

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

intracellular membrane-bounded organelle

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

skeletal system development

biological process

1 reference

1 January 2018

Recombinant human bone morphogenetic protein induces bone formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.

TAS

mesenchyme development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

negative regulation of cell cycle

1 reference

1 January 2018

Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway

protein phosphorylation

1 reference

1 January 2018

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

proteoglycan metabolic process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

mesenchymal cell differentiation

1 reference

1 January 2018

Regulation of BMP7 expression during kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of ERK1 and ERK2 cascade

BMP signaling pathway involved in heart induction

2 references

1 reference

1 January 2018

Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

cardiocyte differentiation

negative regulation of canonical Wnt signaling pathway

1 reference

1 January 2018

BMP-2-enhanced chondrogenesis involves p38 MAPK-mediated down-regulation of Wnt-7a pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

negative regulation of cell population proliferation

IEP

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of p38MAPK cascade

1 reference

1 January 2018

BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

pathway-restricted SMAD protein phosphorylation

regulation of transcription, DNA-templated

1 reference

1 January 2018

DRAGON, a bone morphogenetic protein co-receptor

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

SMAD protein signal transduction

1 reference

24 April 2018

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

regulation of odontogenesis of dentin-containing tooth

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of transcription, DNA-templated

telencephalon development

1 reference

1 January 2018

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

negative regulation of Wnt signaling pathway involved in heart development

1 reference

1 January 2018

Gremlin enhances the determined path to cardiomyogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

cartilage development

1 reference

1 January 2018

bone mineralization involved in bone maturation

1 reference

1 January 2018

Insulin-like growth factor-I induces early osteoblast gene expression in human mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

negative regulation of steroid biosynthetic process

1 reference

1 January 2018

Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of MAPK cascade

1 reference

1 January 2018

BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

chondrocyte differentiation

1 reference

1 January 2018

BMP-2-modulated chondrogenic differentiation in vitro involves down-regulation of membrane-bound beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of bone mineralization

2 references

10 September 2018

MicroRNA-208 modulates BMP-2-stimulated mouse preosteoblast differentiation by directly targeting V-ets erythroblastosis virus E26 oncogene homolog 1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

10 September 2018

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

cellular response to organic cyclic compound

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

negative regulation of transcription by RNA polymerase II

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

positive regulation of phosphatase activity

1 reference

1 January 2018

Effect of rhBMP-2 on the osteogenic potential of bone marrow stromal cells from an osteogenesis imperfecta mouse (oim)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

negative regulation of calcium-independent cell-cell adhesion

1 reference

1 January 2018

BMP-2-modulated chondrogenic differentiation in vitro involves down-regulation of membrane-bound beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of osteoblast differentiation

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Insulin-like growth factor-I induces early osteoblast gene expression in human mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

MicroRNA-208 modulates BMP-2-stimulated mouse preosteoblast differentiation by directly targeting V-ets erythroblastosis virus E26 oncogene homolog 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

protein destabilization

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

osteoblast differentiation

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

The role of histone chaperones in osteoblastic differentiation of C2C12 myoblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of protein binding

1 reference

1 January 2018

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

negative regulation of transcription, DNA-templated

1 reference

1 January 2018

Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

1 reference

1 January 2018

The canonical BMP signaling pathway plays a crucial part in stimulation of dentin sialophosphoprotein expression by BMP-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

negative regulation of aldosterone biosynthetic process

1 reference

1 January 2018

Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of endothelial cell proliferation

1 reference

1 January 2018

Regulation of bone morphogenetic protein signalling in human pulmonary vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

negative regulation of cortisol biosynthetic process

1 reference

1 January 2018

Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 reference

1 January 2018

Recombinant human bone morphogenetic protein induces bone formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of pathway-restricted SMAD protein phosphorylation

TAS

4 references

24 April 2018

Regulation of bone morphogenetic protein signalling in human pulmonary vascular development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

cellular response to growth factor stimulus

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

cellular response to BMP stimulus

endocardial cushion morphogenesis

ISS

multicellular organism development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

negative regulation of cardiac muscle cell differentiation

1 reference

1 January 2018

Gremlin enhances the determined path to cardiomyogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of apoptotic process

1 reference

1 January 2018

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

negative regulation of insulin-like growth factor receptor signaling pathway

1 reference

1 January 2018

Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of transcription by RNA polymerase II

7 references

1 January 2018

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Insulin-like growth factor-I induces early osteoblast gene expression in human mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

cardiac epithelial to mesenchymal transition

1 reference

1 January 2018

Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of pri-miRNA transcription by RNA polymerase II

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of gene expression

4 references

1 January 2018

AntagomiR directed against miR-20a restores functional BMPR2 signalling and prevents vascular remodelling in hypoxia-induced pulmonary hypertension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Bmp signaling promotes intermediate mesoderm gene expression in a dose-dependent, cell-autonomous and translation-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Bone morphogenetic protein 4 regulates microRNAs miR-494 and miR-126-5p in control of endothelial cell function in angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

BMP signaling pathway

10 references

24 April 2018

24 April 2018

Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

AntagomiR directed against miR-20a restores functional BMPR2 signalling and prevents vascular remodelling in hypoxia-induced pulmonary hypertension

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

BMP-2-modulated chondrogenic differentiation in vitro involves down-regulation of membrane-bound beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

The canonical BMP signaling pathway plays a crucial part in stimulation of dentin sialophosphoprotein expression by BMP-2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

regulation of signaling receptor activity

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

negative regulation of transcription by RNA polymerase II

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

response to bacterium

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of pathway-restricted SMAD protein phosphorylation

5 references

1 January 2018

Regulation of bone morphogenetic protein signalling in human pulmonary vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

BMP signaling pathway

11 references

1 January 2018

1 January 2018

Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

AntagomiR directed against miR-20a restores functional BMPR2 signalling and prevents vascular remodelling in hypoxia-induced pulmonary hypertension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

BMP-2-modulated chondrogenic differentiation in vitro involves down-regulation of membrane-bound beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

The canonical BMP signaling pathway plays a crucial part in stimulation of dentin sialophosphoprotein expression by BMP-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

regulation of apoptotic process

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

regulation of MAPK cascade

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

SMAD protein signal transduction

positive regulation of bone mineralization

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

MicroRNA-208 modulates BMP-2-stimulated mouse preosteoblast differentiation by directly targeting V-ets erythroblastosis virus E26 oncogene homolog 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

http://purl.uniprot.org/uniprot/P12643

Gene Atlas image

PBB GE BMP2 205289 at fs.png
732 × 530; 11 KB

0 references

exact match

1 reference

Transforming growth factor beta, conserved site

Identifiers.org

has part(s)

1 reference

Transforming growth factor-beta, C-terminal

1 reference

TGF-beta, propeptide

1 reference

Identifiers

MeSH descriptor ID

D055396

subject named as

Bone Morphogenetic Protein 2

0 references

MeSH tree code

D12.644.276.954.200.200

0 references

D12.776.467.942.200.200

0 references

0 references

1 reference

30 May 2020

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13 November 2019

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference