(Q70633236)

English

Effect of temozolomide and dacarbazine on O6-alkylguanine-DNA alkyltransferase activity and sensitivity of human tumor cells and xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea

scientific article published on 01 January 1993

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8462125%20AND%20SRC:MED&resulttype=core&format=json

12 October 2019

Effect of temozolomide and dacarbazine on O6-alkylguanine-DNA alkyltransferase activity and sensitivity of human tumor cells and xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8462125%20AND%20SRC:MED&resulttype=core&format=json

12 October 2019

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1 reference

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author name string

R B Mitchell

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8462125%20AND%20SRC:MED&resulttype=core&format=json

12 October 2019

M E Dolan

2

1 reference

Europe PubMed Central

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12 October 2019

publication date

1 January 1993

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8462125%20AND%20SRC:MED&resulttype=core&format=json

12 October 2019

Cancer Chemotherapy and Pharmacology

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8462125%20AND%20SRC:MED&resulttype=core&format=json

12 October 2019

32

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8462125%20AND%20SRC:MED&resulttype=core&format=json

12 October 2019

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8462125%20AND%20SRC:MED&resulttype=core&format=json

12 October 2019

59-63

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8462125%20AND%20SRC:MED&resulttype=core&format=json

12 October 2019

https://scigraph.springernature.com/pub.10.1007/bf00685877

0 references

O6-methylguanine and temozolomide can reverse the resistance to chloroethylnitrosoureas of a mouse L1210 leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of a specific DNA repair system and nitrosourea cytotoxicity in resistant human cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible depletion of a DNA repair enzyme in human lymphoma cells by subversive repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential cytotoxicity and DNA-damaging effects produced in human cells of the Mer+ and Mer- phenotypes by a series of alkyltriazenylimidazoles

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxicity of 5-(3-methyl-1-triazeno)imidazole-4-carboxamide (MTIC) on Mer+, Mer+Rem- and Mer- cell lines: differential potentiation by 3-acetamidobenzamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of human lymphocyte O6-alkylguanine-DNA alkyltransferase by streptozotocin in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of O6-alkylguanine pretreatment on the sensitivity of human colon tumor cells to the cytotoxic effects of chloroethylating agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro and in vivo methazolastone-induced DNA damage and repair in L-1210 leukemia sensitive and resistant to chloroethylnitrosoureas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of cross-link formation in chloroethylnitrosourea-treated DNA by an activity in extracts of human leukemic lymphoblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

More than additive toxicity of the combination of 1-methyl-1-nitrosourea plus 1,3-bis(2-chloroethyl)-1-nitrosourea in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation between O6-methylguanine-DNA-methyltransferase activity and resistance of human cells to the cytotoxic and mutagenic effect of N-methyl-N'-nitro-N-nitrosoguanidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-linking of DNA induced by chloroethyinitrosourea is prevented by O6-methyiguanine-DNA methyttransferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of streptozotocin/bis-chloroethylnitrosourea combination therapy on O6-methylguanine DNA methyltransferase activity and mRNA levels in HT-29 cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

O6-alkylguanine-DNA alkyltransferase depletion and regeneration in human peripheral lymphocytes following dacarbazine and fotemustine

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interstrand cross-linking of DNA by 1,3-bis(2-chloroethyl)-1-nitrosourea and other 1-(2-haloethyl)-1-nitrosoureas

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of O6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of O6-alkylguanine-DNA alkyltransferase-mediated carmustine resistance using streptozotocin: a phase I trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of the DNA repair enzyme O6-alkyl guanine alkyltransferase (AT) in cancer chemotherapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA crosslinking and cytotoxicity in normal and transformed human cells treated with antitumor nitrosoureas

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I study of streptozocin- and carmustine-sequenced administration in patients with advanced cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the hepatic O6-alkylguanine-DNA alkyltransferase in vivo by pretreatment with antineoplastic agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potentiation of nitrosourea cytotoxicity in human leukemic cells by inactivation of O6-alkylguanine-DNA alkyltransferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combination therapy: some concepts and results.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of O6-methylguanine-DNA methyltransferase and sensitization of human tumor cells to killing by chloroethylnitrosourea by O6-methylguanine as a free base.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of antibodies to human O6-alkylguanine-DNA alkyltransferase to study the content of this protein in cells treated with O6-benzylguanine or N-methyl-N'-nitro-N-nitrosoguanidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/8462125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF00685877

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8462125%20AND%20SRC:MED&resulttype=core&format=json

12 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8462125%20AND%20SRC:MED&resulttype=core&format=json

12 October 2019

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