(Q7251483)

http://www.ebi.ac.uk/interpro/protein/P19525

Double-stranded RNA-binding domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

9 May 2019

Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense

protein kinase activity

6 references

24 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19525&geneProductId=UniProtKB:P19525

24 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19525&geneProductId=UniProtKB:P19525

24 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19525&geneProductId=UniProtKB:P19525

24 October 2017

Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19525&geneProductId=UniProtKB:P19525

24 October 2017

Nck-1 interacts with PKR and modulates its activation by dsRNA

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19525&geneProductId=UniProtKB:P19525

24 October 2017

Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19525&geneProductId=UniProtKB:P19525

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

non-membrane spanning protein tyrosine kinase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

24 references

9 May 2019

TRAF family proteins link PKR with NF-kappa B activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Nck-1 interacts with PKR and modulates its activation by dsRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Novel role of PKR in inflammasome activation and HMGB1 release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Interaction of human tRNA-dihydrouridine synthase-2 with interferon-induced protein kinase PKR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Latently expressed human herpesvirus 8-encoded interferon regulatory factor 2 inhibits double-stranded RNA-activated protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

The herpes simplex virus type 1 U(S)11 protein interacts with protein kinase R in infected cells and requires a 30-amino-acid sequence adjacent to a kinase substrate domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Homologous regions of the alpha subunit of eukaryotic translational initiation factor 2 (eIF2alpha) and the vaccinia virus K3L gene product interact with the same domain within the dsRNA-activated protein kinase (PKR)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Detection of a novel unglycosylated form of hepatitis C virus E2 envelope protein that is located in the cytosol and interacts with PKR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Novel role of PKR in inflammasome activation and HMGB1 release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Antiviral action of the tumor suppressor ARF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Protein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus envelope protein E2 through the eukaryotic initiation factor 2alpha kinase PERK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Molecular basis for PKR activation by PACT or dsRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Identification of the major phosphorylation site of the hepatitis C virus H strain NS5A protein as serine 2321

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

double-stranded RNA binding

IPI

3 references

9 May 2019

Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

protein tyrosine kinase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

eukaryotic translation initiation factor 2alpha kinase activity

TAS

protein phosphatase regulator activity

1 reference

9 May 2019

The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

identical protein binding

TAS

1 reference

9 May 2019

Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense

IPI

protein kinase activity

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Nck-1 interacts with PKR and modulates its activation by dsRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

eukaryotic translation initiation factor 2alpha kinase activity

IBA

3 references

9 May 2019

The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

1 reference

9 May 2019

Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

1 reference

24 October 2017

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19525&geneProductId=UniProtKB:P19525

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

1 reference

9 May 2019

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

negative regulation of translation

IBA

biological process

3 references

9 May 2019

PKR protein kinase is activated by hepatitis C virus and inhibits viral replication through translational control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Protein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus envelope protein E2 through the eukaryotic initiation factor 2alpha kinase PERK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

regulation of transcription, DNA-templated

1 reference

24 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19525&geneProductId=UniProtKB:P19525

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

immune system process

1 reference

9 May 2019

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

cellular response to amino acid starvation

1 reference

9 May 2019

p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

negative regulation of apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

transcription, DNA-templated

1 reference

24 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19525&geneProductId=UniProtKB:P19525

endoplasmic reticulum unfolded protein response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

protein phosphorylation

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

PKR protein kinase is activated by hepatitis C virus and inhibits viral replication through translational control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

negative regulation of viral genome replication

3 references

9 May 2019

PKR protein kinase is activated by hepatitis C virus and inhibits viral replication through translational control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Double-stranded RNA-activated protein kinase inhibits hepatitis C virus replication but may be not essential in interferon treatment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

positive regulation of NF-kappaB transcription factor activity

1 reference

9 May 2019

TRAF family proteins link PKR with NF-kappa B activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

defense response to virus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

response to interferon-alpha

1 reference

9 May 2019

Double-stranded RNA-activated protein kinase inhibits hepatitis C virus replication but may be not essential in interferon treatment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

negative regulation of osteoblast proliferation

1 reference

9 May 2019

Double-stranded RNA-dependent protein kinase is required for bone calcification in MC3T3-E1 cells in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

protein autophosphorylation

3 references

9 May 2019

Double-stranded RNA-dependent protein kinase is required for bone calcification in MC3T3-E1 cells in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

9 May 2019

Novel role of PKR in inflammasome activation and HMGB1 release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

peptidyl-tyrosine phosphorylation

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

innate immune response

1 reference

9 May 2019

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

response to toxic substance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

regulation of translational initiation by eIF2 alpha phosphorylation

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

regulation of phosphoprotein phosphatase activity

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

negative regulation of cell population proliferation

1 reference

9 May 2019

Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

1 reference

9 May 2019

PKR protein kinase is activated by hepatitis C virus and inhibits viral replication through translational control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

6026

English

retrieved

17 August 2016

EC enzyme number

2.7.10.2

2 references

retrieved

12 October 2015

http://www.uniprot.org/uniprot/P19525.txt?187

14 November 2015

http://www.uniprot.org/uniprot/P19525.txt?version=189

Gene Atlas image

PBB GE EIF2AK2 204211 x at fs.png
732 × 530; 12 KB

0 references

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016