(Q72564592)

English

The lack of CD8 alpha cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8+ T lymphocytes

scientific article published on 01 November 1993

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scholarly article

1 reference

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27 October 2019

The lack of CD8 alpha cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8+ T lymphocytes (English)

1 reference

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27 October 2019

Wai-Ping Fung-Leung

1

1 reference

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27 October 2019

4

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27 October 2019

7

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27 October 2019

author name string

Louie MC

2

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27 October 2019

Limmer A

3

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27 October 2019

Ngo K

5

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27 October 2019

Chen L

6

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27 October 2019

Lacy E

8

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27 October 2019

Loh DY

9

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27 October 2019

Mak TW

10

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27 October 2019

publication date

1 November 1993

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27 October 2019

European Journal of Immunology

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27 October 2019

23

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27 October 2019

2834-2840

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27 October 2019

11

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27 October 2019

T Cell Subsets and the Recognition of MHC Class

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

The expression of CD4 and CD8 accessory molecules on mature T cells is not random but correlates with the specificity of the alpha beta receptor for antigen

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular biology and function of CD4 and CD8

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Analysis of the effector functions of different populations of mucosal lymphocytes

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Cell-cell adhesion mediated by CD8 and MHC class I molecules

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Substitution at residue 227 of H-2 class I molecules abrogates recognition by CD8-dependent, but not CD8-independent, cytotoxic T lymphocytes

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Polymorphism in the alpha 3 domain of HLA-A molecules affects binding to CD8.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Recognition by CD8 on cytotoxic T lymphocytes is ablated by several substitutions in the class I alpha 3 domain: CD8 and the T-cell receptor recognize the same class I molecule

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

The biologic roles of CD2, CD4, and CD8 in T-cell activation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression and function of CD8 in a murine T cell hybridoma

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

A signaling role for the cytoplasmic segment of the CD8 alpha chain detected under limiting stimulatory conditions.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Adhesion versus coreceptor function of CD4 and CD8: role of the cytoplasmic tail in coreceptor activity

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Inability of CD8 alpha' polypeptides to associate with p56lck correlates with impaired function in vitro and lack of expression in vivo.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Negative and positive selection of antigen-specific cytotoxic T lymphocytes affected by the alpha 3 domain of MHC I molecules

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Co-engagement of CD8 with the T cell receptor is required for negative selection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Requirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

CD8 is required during positive selection of CD4-/CD8+ T cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

CD8 is needed for development of cytotoxic T cells but not helper T cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Disruption of CD8-dependent negative and positive selection of thymocytes is correlated with a decreased association between CD8 and the protein tyrosine kinase, p56lck

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Cytotoxic T cells: Lyt phenotype and blocking of killing activity by Lyt antisera

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of anti-Lyt antibodies on T-cell functions

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Transfection of the CD8 gene enhances T-cell recognition.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Reconstitution of MHC class I specificity by transfer of the T cell receptor and Lyt-2 genes

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Synergism in the activation of human CD8 T cells by cross-linking the T-cell receptor complex with the CD8 differentiation antigen

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Cross-linking of the T cell receptor complex with the subset-specific differentiation antigen stimulates interleukin 2 receptor expression in human CD4 and CD8 T cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Effective activation of resting mouse T lymphocytes by cross-linking submitogenic concentrations of the T cell antigen receptor with either Lyt-2 or L3T4

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

CD8 surface levels alter the fate of alpha/beta T cell receptor-expressing thymocytes in transgenic mice

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Susceptibility to lymphocytic choriomeningitis virus isolates correlates directly with early and high cytotoxic T cell activity, as well as with footpad swelling reaction, and all three are regulated by H-2D

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction or prevention of immunopathological disease by cloned cytotoxic T cell lines specific for lymphocytic choriomeningitis virus

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Comparison of thymic and peripheral T cell Ly-2/3 antigens

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Two Lyt-2 polypeptides arise from a single gene by alternative splicing patterns of mRNA.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

An immunological role for the CD8 beta-chain

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Gene transfer of the Ly-3 chain gene of the mouse CD8 molecular complex: co-transfer with the Ly-2 polypeptide gene results in detectable cell surface expression of the Ly-3 antigenic determinants.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Recovery from acute virus infection. Role of cytotoxic T lymphocytes in the elimination of lymphocytic choriomeningitis virus from spleens of mice

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

The immune response of the mouse to lymphocytic choriomeningitis virus. V. High numbers of cytolytic T lymphocytes are generated in the spleen during acute infection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

LCMV-specific, class II-restricted cytotoxic T cells in beta 2-microglobulin-deficient mice

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Clonal heterogeneity in the functional requirement for Lyt-2/3 molecules on cytolytic T lymphocytes (CTL): possible implications for the affinity of CTL antigen receptors.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Clonal heterogeneity in the requirement for T3, T4, and T8 molecules in human cytolytic T lymphocyte function

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Antigen recognition by H-2-restricted cytolytic T lymphocytes: inhibition of cytolysis by anti-CD8 monoclonal antibodies depends upon both concentration and primary sequence of peptide antigen

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Correlation between CD8 dependency and determinant density using peptide-induced, Ld-restricted cytotoxic T lymphocytes

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231117

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/EJI.1830231117

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8223860%20AND%20SRC:MED&resulttype=core&format=json

27 October 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8223860%20AND%20SRC:MED&resulttype=core&format=json

27 October 2019

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