(Q72678287)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8269603%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

title

Phase I study of 5-fluorouracil and leucovorin by a 14-day circadian infusion in metastatic adenocarcinoma patients (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8269603%20AND%20SRC:MED&resulttype=core&format=json

metastatic adenocarcinoma

28 October 2019

main subject

1 reference

1 reference

1 reference

1

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28 October 2019

author name string

I G Kerr

2

1 reference

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28 October 2019

N Doyle

3

1 reference

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28 October 2019

M Macdonald

4

1 reference

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28 October 2019

M Sone

5

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28 October 2019

publication date

1 January 1993

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Cancer Chemotherapy and Pharmacology

28 October 2019

published in

1 reference

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28 October 2019

volume

33

1 reference

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28 October 2019

issue

3

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28 October 2019

page(s)

221-228

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https://scigraph.springernature.com/pub.10.1007/bf00686220

28 October 2019

exact match

0 references

cites work

The effect of time of administration of 5-fluorouracil on leucopenia in the rat

1 reference

12 December 2020

Circadian variation of 5-fluorouracil catabolism in isolated perfused rat liver

1 reference

12 December 2020

Circadian rhythm of orotate phosphoribosyltransferase, pyrimidine nucleoside phosphorylases and dihydrouracil dehydrogenase in mouse liver. Possible relevance to chemotherapy with 5-fluoropyrimidines.

1 reference

12 December 2020

Circadian rhythm of rat liver dihydropyrimidine dehydrogenase. Possible relevance to fluoropyrimidine chemotherapy

1 reference

12 December 2020

Circadian patterning of continuous floxuridine infusion reduces toxicity and allows higher dose intensity in patients with widespread cancer

1 reference

12 December 2020

Circadian variations in pyrimidine nucleotide synthesis in rat liver

1 reference

12 December 2020

Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency. A potentially more common pharmacogenetic syndrome

1 reference

12 December 2020

Use of oral uridine as a substitute for parenteral uridine rescue of 5-fluorouracil therapy, with and without the uridine phosphorylase inhibitor 5-benzylacyclouridine

1 reference

12 December 2020

Determination of the therapeutic index of floxuridine by its circadian infusion pattern

1 reference

12 December 2020

Circadian gating of S phase in human ovarian cancer.

1 reference

12 December 2020

Relationship between circadian-dependent toxicity of 5-fluorodeoxyuridine and circadian rhythms of pyrimidine enzymes: possible relevance to fluoropyrimidine chemotherapy

1 reference

12 December 2020

Effect of biological time on the determination of the LD50 of 5-fluorouracil in mice.

1 reference

12 December 2020

Effects of the plasma concentration of 5-fluorouracil and the duration of continuous venous infusion of 5-fluorouracil with an inhibitor of 5-fluorouracil degradation on Yoshida sarcomas in rats.

1 reference

12 December 2020

The effects of leucovorin and dipyridamole on fluoropyrimidine-induced radiosensitization.

1 reference

12 December 2020

Familial pyrimidinemia and pyrimidinuria associated with severe fluorouracil toxicity

1 reference

12 December 2020

A chronopharmacologic phase II clinical trial with 5-fluorouracil, folinic acid, and oxaliplatin using an ambulatory multichannel programmable pump. High antitumor effectiveness against metastatic colorectal cancer

1 reference

12 December 2020

Modulation of fluoropyrimidines by leucovorin: Rational and status

1 reference

12 December 2020

Circadian rhythm of cellular proliferation in the human rectal mucosa

1 reference

12 December 2020

A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: a Mid-Atlantic Oncology Program Study

1 reference

12 December 2020

Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile

1 reference

12 December 2020

Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity

1 reference

12 December 2020

Circadian rhythm and 5-fluorouracil toxicity in C3H mice

1 reference

12 December 2020

Circadian rhythm of hepatic uridine phosphorylase activity and plasma concentration of uridine in mice

1 reference

12 December 2020

Diurnal variation in the intestinal toxicity of 5-fluorouracil in the rat

1 reference

12 December 2020

DNA synthesis in human bone marrow is circadian stage dependent

1 reference

12 December 2020

Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infus

1 reference

12 December 2020

Diurnal variation in the therapeutic efficacy of 5-fluorouracil against murine colon cancer

1 reference

12 December 2020

Biochemical modulation of fluorouracil with leucovorin: confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer

1 reference

12 December 2020

Schedule-dependent enhancement of the cytotoxicity of fluoropyrimidines to human carcinoma cells in the presence of folinic acid

1 reference

12 December 2020

DNA synthesis and ploidy in non-Hodgkin's lymphomas demonstrate intrapatient variation depending on circadian stage of cell sampling

1 reference

12 December 2020

A phase I clinical trial of combined fluoropyrimidines with leucovorin in a 14-day infusion. Demonstration of biochemical modulation

1 reference

12 December 2020

Mitotic activity in the human epidermis

1 reference

12 December 2020

Biological modification of protracted infusion of 5-fluorouracil with weekly leucovorin. A dose seeking clinical trial for patients with disseminated gastrointestinal cancers

1 reference

12 December 2020

Circadian variation of fluoropyrimidine catabolic enzymes in rat liver: possible relevance to 5-fluorodeoxyuridine chemotherapy

1 reference

12 December 2020

Prolonged continuous infusion of fluorouracil with weekly bolus leucovorin: a phase II study in patients with disseminated colorectal cancer

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF00686220

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8269603%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

1 reference