(Q72746247)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7937515%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

title

The role of intramolecular nucleophilic catalysis and the effects of self-association on the deamidation of human insulin at low pH (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7937515%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

author name string

R T Darrington

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7937515%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

B D Anderson

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7937515%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

publication date

1 June 1994

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7937515%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

published in

Pharmaceutical Research

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7937515%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

volume

11

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28 October 2019

issue

6

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28 October 2019

page(s)

784-793

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7937515%20AND%20SRC:MED&resulttype=core&format=json

1H NMR spectrum of the native human insulin monomer. Evidence for conformational differences between the monomer and aggregated forms

28 October 2019

cites work

1 reference

12 December 2020

Chemical pathways of peptide degradation. IV. Pathways, kinetics, and mechanism of degradation of an aspartyl residue in a model hexapeptide

1 reference

12 December 2020

Free covalent aggregates of therapeutic insulin in blood of insulin-dependent diabetics

1 reference

12 December 2020

Specificity of the cleavage of proteins by dilute acid. I. Release of aspartic acid from insulin, ribonuclease, and glucagon

1 reference

12 December 2020

Soluble, prolonged-acting insulin derivatives. III. Degree of protraction, crystallizability and chemical stability of insulins substituted in positions A21, B13, B23, B27 and B30

1 reference

12 December 2020

Spontaneous deamidation of a protein antibiotic, neocarzinostatin, at weakly acidic pH. Conversion to a homologous inactive preneocarzinostatin due to change of asparagine 83 to aspartic acid 83 accompanied by conformational and biological alteratio

1 reference

12 December 2020

Carboxyl group catalysis of acyl transfer reactions in corticosteroid 17- and 21-monoesters

1 reference

12 December 2020

Hydrolysis of Proteins

1 reference

12 December 2020

The structure of 2Zn pig insulin crystals at 1.5 A resolution

1 reference

12 December 2020

Deamidation of the asparaginyl-glycyl sequence

1 reference

12 December 2020

Sequence and structure determinants of the nonenzymatic deamidation of asparagine and glutamine residues in proteins

1 reference

12 December 2020

An equilibrium ultracentrifuge study of the self-association of bovine insulin

1 reference

12 December 2020

28 Cleavage at aspartic acid

1 reference

12 December 2020

Evidence for isoaspartyl (deamidated) forms of mouse epidermal growth factor.

1 reference

12 December 2020

The mechanisms of irreversible enzyme inactivation at 100C.

1 reference

12 December 2020

Action of carboxypeptidase- A on bovine insulin: preparation of desalanine-desasparagine-insulin

1 reference

12 December 2020

Molecular basis for the accumulation of acidic isozymes of triosephosphate isomerase on aging

1 reference

12 December 2020

Chemical pathways of peptide degradation. I. Deamidation of adrenocorticotropic hormone

1 reference

12 December 2020

Detection of desamido forms of purified bovine growth hormone.

1 reference

12 December 2020

Chemical stability of insulin. 4. Mechanisms and kinetics of chemical transformations in pharmaceutical formulation

1 reference

12 December 2020

The liberation of aspartic acid during the acid hydrolysis of proteins

1 reference

12 December 2020

Fingerprint analysis of insulin and proinsulins

1 reference

12 December 2020

Conformational flexibility of aqueous monomeric and dimeric insulin: a molecular dynamics study

1 reference

12 December 2020

An explantion for the determination of "self" versus "non-self" proteins

1 reference

12 December 2020

Deamidation of glutaminyl and asparaginyl residues in peptides and proteins.

1 reference

12 December 2020

The thermodynamics of bovine and porcine insulin and proinsulin association determined by concentration difference spectroscopy.

1 reference

12 December 2020

The hydrolysis of insulin and human serum albumin in dilute hydrochloric acid

1 reference

12 December 2020

Separation and characterization of acid-induced insulin transformation products by paper electrophoresis in 7 M urea

1 reference

12 December 2020

Nonenzymatic methods for the preferential and selective cleavage and modification of proteins

1 reference

12 December 2020

Relationship of structure to biological activity of insulin as revealed by degradative studies

1 reference

12 December 2020

Controlled deamidation of peptides and proteins: an experimental hazard and a possible biological timer

1 reference

12 December 2020

EVIDENCE FOR TWO TYPES OF CONVERSION REACTIONS FOR PROLACTIN AND GROWTH HORMONE

1 reference

12 December 2020

Synthesis of a polypeptide with lysozyme activity

1 reference

12 December 2020

The labile amide in insulin: preparation of desalanine-desamido-insulin

1 reference

12 December 2020

Evolution and the Distribution of Glutaminyl and Asparaginyl Residues in Proteins

1 reference

12 December 2020

Insulin self-association. Spectrum changes and thermodynamics

1 reference

12 December 2020

Propensity for spontaneous succinimide formation from aspartyl and asparaginyl residues in cellular proteins

1 reference

12 December 2020

Zinc binding, circular dichroism, and equilibrium sedimentation studies on insulin (bovine) and several of its derivatives

1 reference

12 December 2020

Deamidation of asparaginyl residues in proteins: a potential pathway for chemical degradation of proteins in lyophilized dosage forms

1 reference

12 December 2020

1H Fourier transform NMR studies of insulin: coordination of Ca2+ to the Glu(B13) site drives hexamer assembly and induces a conformation change

1 reference

12 December 2020

INTRAMOLECULAR MODELS DEPICTING THE KINETIC IMPORTANCE OF "FIT" IN ENZYMATIC CATALYSIS.

1 reference

12 December 2020

The intramolecular facilitated hydrolytic rates of methyl-substituted succinanilic acids

1 reference

12 December 2020

Chemical stability of insulin. 2. Formation of higher molecular weight transformation products during storage of pharmaceutical preparations

1 reference

12 December 2020

Human monocomponent insulin. Chemistry and characteristics

1 reference

12 December 2020

Chemical pathways of peptide degradation. II. Kinetics of deamidation of an asparaginyl residue in a model hexapeptide

1 reference

12 December 2020

Polymerization pattern of insulin at pH 7.0

1 reference

12 December 2020

Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation

1 reference

12 December 2020

Identifiers

DOI

10.1023/A:1018909220255

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7937515%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

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