Wikidata

(Q7276719)

English

Ras homolog family member A

mammalian protein found in Homo sapiens

  • small GTP binding protein RhoA
  • Rho cDNA clone 12
  • RHOA
  • epididymis secretory sperm binding protein
  • h12
  • Aplysia ras-related homolog 12
  • oncogene RHO H12
  • transforming protein RhoA
  • rhoA GTP-Binding Protein
  • Transforming protein RhoA
In more languages

Statements

molecular function
protein binding
determination method
IPI
44 references
retrieved
8 April 2019
stated in
The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex
GOA
curator
UniProt
UniProt protein ID
P61586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
The armadillo protein p0071 regulates Rho signalling during cytokinesis
GOA
curator
UniProt
UniProt protein ID
P61586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
Fam65b is a new transcriptional target of FOXO1 that regulates RhoA signaling for T lymphocyte migration
GOA
curator
UniProt
UniProt protein ID
P61586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells
GOA
curator
UniProt
UniProt protein ID
P61586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression
GOA
curator
UniProt
UniProt protein ID
P61586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA
GOA
curator
UniProt
UniProt protein ID
P61586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
RHO binding to FAM65A regulates Golgi reorientation during cell migration
GOA
curator
UniProt
UniProt protein ID
P61586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils
GOA
curator
UniProt
UniProt protein ID
P61586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
Identification, characterization, and functional analysis of heart-specific myosin light chain phosphatase small subunit
GOA
curator
UniProt
UniProt protein ID
P61586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity
GOA
curator
UniProt
UniProt protein ID
P61586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
Activation of a bacterial virulence protein by the GTPase RhoA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
The role of ezrin-associated protein network in human sperm capacitation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
Arachidonic acid stimulates formation of a novel complex containing nucleolin and RhoA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
WGEF activates Rho in the Wnt-PCP pathway and controls convergent extension in Xenopus gastrulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
Plk4 is required for cytokinesis and maintenance of chromosomal stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
A Salmonella typhimurium-translocated glycerophospholipid:cholesterol acyltransferase promotes virulence by binding to the RhoA protein switch regions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
A comprehensive resource of interacting protein regions for refining human transcription factor networks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
Effect of cancer-associated mutations in the PlexinB1 gene
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
Distinct biological activities of C3 and ADP-ribosyltransferase-deficient C3-E174Q
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
Prenylated Rab acceptor protein is a receptor for prenylated small GTPases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis for the selective activation of Rho GTPases by Dbl exchange factors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
Structural insights into the interaction of ROCKI with the switch regions of RhoA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
How RhoGDI binds Rho
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
MgF(3)(-) as a transition state analog of phosphoryl transfer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
Advanced glycation end products increase endothelial permeability through the RAGE/Rho signaling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
Inter-domain motions of the N-domain of the KdpFABC complex, a P-type ATPase, are not driven by ATP-induced conformational changes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
WNT-3a modulates platelet function by regulating small GTPase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
The small GTPase RalA targets filamin to induce filopodia
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
A Salmonella typhimurium-translocated glycerophospholipid:cholesterol acyltransferase promotes virulence by binding to the RhoA protein switch regions
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
retrieved
8 April 2019
stated in
Activation of a bacterial virulence protein by the GTPase RhoA
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IPI
GTPase activity
determination method
EXP
IBA
IDA
IEA
TAS
8 references
retrieved
8 April 2019
stated in
Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase
GOA
curator
UniProt
UniProt protein ID
P61586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IEA
retrieved
8 April 2019
stated in
Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells
GOA
curator
UniProt
UniProt protein ID
P61586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IDA
retrieved
8 April 2019
stated in
Role of Kenae/CCDC125 in cell motility through the deregulation of RhoGTPase.
GOA
curator
UniProt
UniProt protein ID
P61586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IDA
retrieved
8 April 2019
stated in
Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression
GOA
curator
UniProt
UniProt protein ID
P61586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
IBA
retrieved
8 April 2019
stated in
Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586
determination method
EXP
cell component
biological process
Gene Atlas image
PBB GE RHOA 200736 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
D020742
subject named as
rhoA GTP-Binding Protein
0 references
PDB structure ID
 
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