(Q73226720)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10581400%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

title

L-DOPA-quinone inactivates tryptophan hydroxylase and converts the enzyme to a redox-cycling quinoprotein (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10581400%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

author name string

D M Kuhn

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10581400%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

R E Arthur

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10581400%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

publication date

1 November 1999

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10581400%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

published in

Molecular Brain Research

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10581400%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

volume

73

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10581400%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

issue

1-2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10581400%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

page(s)

78-84

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10581400%20AND%20SRC:MED&resulttype=core&format=json

Dopaminergic transplants alter in vivo activity of tryptophan hydroxylase in the striatum in a rat model of Parkinson's disease.

2 November 2019

cites work

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A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease.

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7 January 2021

Comparison of neurotoxicity following repeated administration of l-dopa, d-dopa and dopamine to embryonic mesencephalic dopamine neurons in cultures derived from Fisher 344 and Sprague-Dawley donors.

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7 January 2021

Immunohistochemical evidence that central serotonin neurons produce dopamine from exogenous L-DOPA in the rat, with reference to the involvement of aromatic L-amino acid decarboxylase

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7 January 2021

Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes

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7 January 2021

L-dopa cytotoxicity to PC12 cells in culture is via its autoxidation.

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7 January 2021

Dopamine Neurotoxicity: Inhibition of Mitochondrial Respiration

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7 January 2021

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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7 January 2021

Differential neurotoxicity induced by L-DOPA and dopamine in cultured striatal neurons

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7 January 2021

Sequence of two mRNAs encoding active rat tryptophan hydroxylase

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7 January 2021

Hypothesis: a damaging role in aging for reactive protein oxidation products?

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7 January 2021

Tissue sulfhydryl groups

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7 January 2021

The oxidant stress hypothesis in Parkinson's disease: evidence supporting it

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7 January 2021

Presence of dopa and amino acid hydroperoxides in proteins modified with advanced glycation end products (AGEs): amino acid oxidation products as a possible source of oxidative stress induced by AGE proteins

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7 January 2021

Evidence that the large neutral amino acid L-valine decreases electrically-evoked release of 5-HT in rat hippocampus in vivo

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7 January 2021

Protein-bound 3,4-dihydroxyphenylalanine is a major reductant formed during hydroxyl radical damage to proteins.

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7 January 2021

Loss of brainstem serotonin- and substance P-containing neurons in Parkinson's disease.

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7 January 2021

Neuropathology of immunohistochemically identified brainstem neurons in Parkinson's disease.

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7 January 2021

Reactive oxygen species and the central nervous system

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7 January 2021

Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections

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7 January 2021

Reactive dopamine metabolites and neurotoxicity: implications for Parkinson's disease

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7 January 2021

Identification of catechol-protein conjugates in neostriatal slices incubated with [3H]dopamine: impact of ascorbic acid and glutathione

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7 January 2021

Inhibition of tryptophan hydroxylase by benserazide and other catechols

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7 January 2021

Actions of 6-hydroxydopamine quinones on catecholamine neurons

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7 January 2021

Tyrosinase-catalyzed binding of 3,4-dihydroxyphenylalanine with proteins through the sulfhydryl group

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7 January 2021

Dopamine inactivates tryptophan hydroxylase and forms a redox-cycling quinoprotein: possible endogenous toxin to serotonin neurons

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7 January 2021

Molecular mechanism of the inactivation of tryptophan hydroxylase by nitric oxide: attack on critical sulfhydryls that spare the enzyme iron center.

1 reference

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7 January 2021

Phosphorylation and activation of brain tryptophan hydroxylase: identification of serine-58 as a substrate site for protein kinase A.

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7 January 2021

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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7 January 2021

Brain mitochondria catalyze the oxidation of 7-(2-aminoethyl)-3,4-dihydro-5-hydroxy-2H-1,4-benzothiazine-3-carboxyli c acid (DHBT-1) to intermediates that irreversibly inhibit complex I and scavenge glutathione: potential relevance to the pathogenes

1 reference

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7 January 2021

Dopamine, 6-hydroxydopamine, iron, and dioxygen--their mutual interactions and possible implication in the development of Parkinson's disease

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7 January 2021

The mechanism of perturbation in monoamine metabolism by L-dopa therapy: in vivo and in vitro studies

1 reference

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7 January 2021

The protein oxidation product 3,4-dihydroxyphenylalanine (DOPA) mediates oxidative DNA damage

1 reference

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7 January 2021

Inhibition of tryptophan hydroxylase by dopamine and the precursor amino acids

1 reference

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7 January 2021

The effects of hydroxyl radical attack on dopa, dopamine, 6-hydroxydopa, and 6-hydroxydopamine

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7 January 2021

Iron-mediated oxidation of 3,4-dihydroxyphenylalanine to an excitotoxin

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7 January 2021

Etiology and pathogenesis of Parkinson's disease

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7 January 2021

Toxic effects of L-DOPA on mesencephalic cell cultures: protection with antioxidants.

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7 January 2021

Role of endogenous glutathione in the oxidation of dopamine.

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7 January 2021

Reassessment of Ellman's reagent

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7 January 2021

Detection of 5-S-cysteinyldopamine in human brain

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7 January 2021

Free radical and enzymatic mechanisms for the generation of protein bound reducing moieties

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7 January 2021

Long-lived reactive species on free-radical-damaged proteins

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7 January 2021

The oxidative metabolism of catecholamines in the brain: a review

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7 January 2021

Conjugates of catecholamines with cysteine and GSH in Parkinson's disease: possible mechanisms of formation involving reactive oxygen species.

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7 January 2021

Tyrosinase enhances the covalent modification of DNA by dopamine.

1 reference

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7 January 2021

Role of serotonergic neurons in L-DOPA-derived extracellular dopamine in the striatum of 6-OHDA-lesioned rats.

1 reference

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7 January 2021

The metabolism of exogenous L-dopa in the brain: an immunohistochemical study of its conversion to dopamine in non-catecholaminergic cells of the rat brain

1 reference

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7 January 2021

10.1016/S0169-328X(99)00238-7

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10581400%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

1 reference