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Mechanism of p53 degradation
scientific article published on 01 April 1997
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Europe PubMed Central
PubMed publication ID
9141469
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9141469%20AND%20SRC:MED&resulttype=core&format=json
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3 November 2019
title
Mechanism of p53 degradation
(English)
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stated in
Europe PubMed Central
PubMed publication ID
9141469
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9141469%20AND%20SRC:MED&resulttype=core&format=json
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3 November 2019
author
Michele Pagano
series ordinal
2
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Europe PubMed Central
PubMed publication ID
9141469
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9141469%20AND%20SRC:MED&resulttype=core&format=json
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3 November 2019
author name string
J P Brown
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1
1 reference
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Europe PubMed Central
PubMed publication ID
9141469
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9141469%20AND%20SRC:MED&resulttype=core&format=json
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3 November 2019
language of work or name
English
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publication date
1 April 1997
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Europe PubMed Central
PubMed publication ID
9141469
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retrieved
3 November 2019
published in
Biochimica et Biophysica Acta
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Europe PubMed Central
PubMed publication ID
9141469
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9141469%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 November 2019
volume
1332
1 reference
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Europe PubMed Central
PubMed publication ID
9141469
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9141469%20AND%20SRC:MED&resulttype=core&format=json
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3 November 2019
issue
2
1 reference
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Europe PubMed Central
PubMed publication ID
9141469
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9141469%20AND%20SRC:MED&resulttype=core&format=json
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3 November 2019
page(s)
O1-6
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Europe PubMed Central
PubMed publication ID
9141469
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9141469%20AND%20SRC:MED&resulttype=core&format=json
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3 November 2019
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Atm-deficient mice: a paradigm of ataxia telangiectasia
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Reduction in p53 synthesis during differentiation of Friend-erythroleukemia cells. Correlation with the commitment to terminal cell division
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Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway
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The ubiquitin-proteasome proteolytic pathway
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Degradation of nuclear oncoproteins by the ubiquitin system in vitro
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Sensitivity of p53 lysine mutants to ubiquitin-directed degradation targeted by human papillomavirus E6
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7 January 2021
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Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation
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Variety in the level of gene control in eukaryotic cells
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p53-dependent cell cycle arrest induced by N-acetyl-L-leucinyl-L-leucinyl-L-norleucinal in platelet-derived growth factor-stimulated human fibroblasts
1 reference
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DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
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A genetic model for colorectal tumorigenesis
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Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life
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Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
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Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.
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Clinical implications of the p53 tumor-suppressor gene
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Strange bedfellows in even stranger places: the role of ATM in meiotic cells, lymphocytes, tumors, and its functional links to p53.
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p53 mutations in human cancers
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7 January 2021
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Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes
1 reference
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Crossref
reference URL
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7 January 2021
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Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.
1 reference
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based on heuristic
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Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins
1 reference
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reference URL
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7 January 2021
based on heuristic
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Regulation of the specific DNA binding function of p53
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Small peptides activate the latent sequence-specific DNA binding function of p53.
1 reference
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Crossref
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7 January 2021
based on heuristic
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Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Protein degradation: de-ubiquitinate to decide your fate
1 reference
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7 January 2021
based on heuristic
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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
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Signalling to p53: where does it all start?
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Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway
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p53: puzzle and paradigm
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Worrying about p53
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T antigen is bound to a host protein in SY40-transformed cells
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Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation
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A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.
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Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
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Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis
1 reference
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Crossref
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Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells
1 reference
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Crossref
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7 January 2021
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A conformation hypothesis for the suppressor and promoter functions ofp53in cell growth control and in cancer
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900048-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900048-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900048-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Human cytomegalovirus elevates levels of the cellular protein p53 in infected fibroblasts
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900048-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Post-Translational Regulation of the 54K Cellular Tumor Antigen in Normal and Transformed Cells
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
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7 January 2021
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Control of gene expression by proteolysis
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Multiple molecular levels of cell cycle regulation
1 reference
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reference URL
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7 January 2021
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inferred from DOI database lookup
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
1 reference
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7 January 2021
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inferred from DOI database lookup
Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP)
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Proteolysis: The proteasome: a protein-degrading organelle?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900048-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900048-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900048-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900048-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900048-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900048-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900048-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Complete reconstitution of conjugation and subsequent degradation of the tumor suppressor protein p53 by purified components of the ubiquitin proteolytic system
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900048-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Potential role of human cytomegalovirus and p53 interaction in coronary restenosis
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900048-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a novel p53 promoter element involved in genotoxic stress-inducible p53 gene expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900048-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic alterations during colorectal-tumor development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900048-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Association of human papillomavirus types 16 and 18 E6 proteins with p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900048-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Dual roles of ATM in the cellular response to radiation and in cell growth control.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900048-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of cellular p53 activity by DNA-damaging agents and growth arrest.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900048-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Human papillomaviruses.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900048-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0304-419X(96)00048-0
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9141469
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9141469%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 November 2019
PubMed publication ID
9141469
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9141469
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9141469%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 November 2019
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