(Q73342628)

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Methapyrilene hepatotoxicity is associated with increased hepatic glutathione, the formation of glucuronide conjugates, and enterohepatic recirculation

scientific article published on 01 December 2000

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11137066%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Methapyrilene hepatotoxicity is associated with increased hepatic glutathione, the formation of glucuronide conjugates, and enterohepatic recirculation (English)

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Europe PubMed Central

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3 November 2019

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G S Ratra

1

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3 November 2019

C J Powell

2

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3 November 2019

B K Park

3

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3 November 2019

J L Maggs

4

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3 November 2019

S Cottrell

5

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3 November 2019

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1 December 2000

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3 November 2019

Chemico-biological Interactions

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3 November 2019

129

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3 November 2019

3

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3 November 2019

279-295

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3 November 2019

Liver tumors induced in rats by oral administration of the antihistaminic methapyrilene hydrochloride

1 reference

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Effects of methapyrilene on rat hepatic xenobiotic metabolizing enzymes and liver morphology

1 reference

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Methapyrilene hepatotoxicity is associated with oxidative stress, mitochondrial disfunction and is prevented by the Ca2+ channel blocker verapamil

1 reference

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Importance and regulation of hepatic glutathione

1 reference

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Glutathione metabolism and its role in hepatotoxicity

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The Role of Active Metabolites in Drug Toxicity

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Enalapril hepatotoxicity in the rat. Effects of modulators of cytochrome P450 and glutathione

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Biliary excretion of glutathione and glutathione disulfide in the rat. Regulation and response to oxidative stress

1 reference

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Comparison of the short-term effects of di(2-ethylhexyl) phthalate, di(n-hexyl) phthalate, and di(n-octyl) phthalate in rats

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7 January 2021

Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine

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7 January 2021

A fluorometric method for determination of oxidized and reduced glutathione in tissues

1 reference

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7 January 2021

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues

1 reference

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7 January 2021

Glutathione biosynthesis; gamma-glutamylcysteine synthetase from rat kidney

1 reference

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7 January 2021

Circadian periodicity of tissue glutathione and its relationship with lipid peroxidation in rats

1 reference

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7 January 2021

Metabolism of methapyrilene by Fischer-344 rat and B6C3F1 mouse hepatocytes

1 reference

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7 January 2021

Evidence for thiophene-S-oxide as a primary reactive metabolite of thiophene in vivo: formation of a dihydrothiophene sulfoxide mercapturic acid

1 reference

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7 January 2021

Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid

1 reference

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7 January 2021

Thiophene sulfoxides as reactive metabolites: formation upon microsomal oxidation of a 3-aroylthiophene and fate in the presence of nucleophiles in vitro and in vivo.

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7 January 2021

Resistance of precision-cut liver slices to the toxic effects of menadione.

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7 January 2021

Thiophene S-oxides as new reactive metabolites: formation by cytochrome P-450 dependent oxidation and reaction with nucleophiles

1 reference

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7 January 2021

Ultrastructural changes in the liver of animals treated with methapyrilene and some analogs.

1 reference

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7 January 2021

Chronic toxicity tests of pyrilamine maleate and methapyrilene hydrochloride in F344 rats

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7 January 2021

Carcinogenicity of methapyrilene hydrochloride, mepyramine hydrochloride, thenyldiamine hydrochloride, and pyribenzamine hydrochloride in Sprague-Dawley rats.

1 reference

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7 January 2021

The in vivo metabolism of methapyrilene, a hepatocarcinogen, in the rat

1 reference

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7 January 2021

Glutathione and lipid peroxide levels in rat liver following administration of methapyrilene and analogs.

1 reference

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7 January 2021

Relationship between peroxisome-proliferating sulfur-substituted fatty acid analogs, hepatic lipid peroxidation and hydrogen peroxide metabolism

1 reference

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7 January 2021

Effect of BCNU pretreatment on diquat-induced oxidant stress and hepatotoxicity.

1 reference

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7 January 2021

Characterization of the hepatic responses to the short-term administration of ciprofibrate in several rat strain. Co-induction of microsomal cytochrome P-450 IVA1 and peroxisome proliferation

1 reference

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7 January 2021

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10.1016/S0009-2797(00)00253-2

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11137066%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11137066%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

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