(Q73434298)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11175341%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

title

Grb2 downregulation leads to Akt inactivation in heregulin-stimulated and ErbB2-overexpressing breast cancer cells (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11175341%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

author name string

Lim SJ

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11175341%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Lopez-Berestein G

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11175341%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Hung MC

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11175341%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Lupu R

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11175341%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Tari AM

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11175341%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

language of work or name

English

0 references

publication date

1 December 2000

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11175341%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11175341%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

volume

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11175341%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

issue

54

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11175341%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

page(s)

6271-6276

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11175341%20AND%20SRC:MED&resulttype=core&format=json

Mechanism of activation and function of protein kinase B.

3 November 2019

cites work

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Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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Heregulin stimulates mitogenesis and phosphatidylinositol 3-kinase in mouse fibroblasts transfected with erbB2/neu and erbB3.

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7 January 2021

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NDF/heregulin-induced cell cycle changes and apoptosis in breast tumour cells: role of PI3 kinase and p38 MAP kinase pathways

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7 January 2021

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7 January 2021

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7 January 2021

Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase

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PI3K: downstream AKTion blocks apoptosis

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7 January 2021

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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7 January 2021

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Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor

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7 January 2021

Identification of heregulin, a specific activator of p185erbB2

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7 January 2021

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7 January 2021

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

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7 January 2021

Heregulin regulation of Akt/protein kinase B in breast cancer cells

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7 January 2021

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

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7 January 2021

Characterization of a growth factor that binds exclusively to the erbB-2 receptor and induces cellular responses

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7 January 2021

Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge

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7 January 2021

Analysis of the role of the Shc and Grb2 proteins in signal transduction by the v-ErbB protein

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7 January 2021

Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers

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7 January 2021

Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells

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7 January 2021

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family

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7 January 2021

Heregulin induces tyrosine phosphorylation of HER4/p180erbB4

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7 January 2021

Interaction of Shc with Grb2 regulates association of Grb2 with mSOS

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7 January 2021

Phosphatidylinositol-3-OH kinase as a direct target of Ras

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7 January 2021

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

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7 January 2021

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

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7 January 2021

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

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7 January 2021

Inhibition of Grb2 and Crkl proteins results in growth inhibition of Philadelphia chromosome positive leukemic cells

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7 January 2021

Growth inhibition of breast cancer cells by Grb2 downregulation is correlated with inactivation of mitogen-activated protein kinase in EGFR, but not in ErbB2, cells

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7 January 2021

Serum predominantly activates MAPK and akt kinases in EGFR- and ErbB2-over-expressing cells, respectively

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7 January 2021

Regulation of transcription by MAP kinase cascades

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7 January 2021

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7 January 2021

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7 January 2021

Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu

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7 January 2021