(Q73472642)

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Formation of DNA adducts and induction of mutagenic effects in rats following 4 weeks inhalation exposure to ethylene oxide as a basis for cancer risk assessment

scientific article published on 01 January 2000

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Europe PubMed Central

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4 November 2019

Formation of DNA adducts and induction of mutagenic effects in rats following 4 weeks inhalation exposure to ethylene oxide as a basis for cancer risk assessment (English)

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4 November 2019

exposure assessment

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Peter J Boogaard

2

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4 November 2019

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N J van Sittert

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4 November 2019

A T Natarajan

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4 November 2019

A D Tates

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4 November 2019

L G Ehrenberg

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4 November 2019

M A Törnqvist

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4 November 2019

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1 January 2000

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4 November 2019

Mutation Research

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4 November 2019

447

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4 November 2019

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4 November 2019

27-48

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4 November 2019

Review of the mutagenicity of ethylene oxide

1 reference

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7 January 2021

Cytogenetic effects of ethylene oxide, with an emphasis on population monitoring

1 reference

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7 January 2021

A two-year inhalation study of the carcinogenic potential of ethylene oxide in Fischer 344 rats

1 reference

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7 January 2021

Frequency, size and location of brain tumours in F-344 rats chronically exposed to ethylene oxide

1 reference

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7 January 2021

Carcinogenic and toxicologic effects of inhaled ethylene oxide and propylene oxide in F344 rats

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7 January 2021

Ethylene oxide cancer risk assessment based on epidemiological data: application of revised regulatory guidelines

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7 January 2021

Reaction products in hemoglobin and DNA after in vitro treatment with ethylene oxide and N-(2-hydroxyethyl)-N-nitrosourea.

1 reference

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7 January 2021

In vitro reaction of ethylene oxide with DNA and characterization of DNA adducts

1 reference

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7 January 2021

Impact of DNA nucleotide excision repair on methyl methanesulfonate-induced mutations in Drosophila melanogaster.

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7 January 2021

Formation and persistence of DNA adducts in pouch skin fibroblasts and liver tissue of rats exposed in vivo to the monofunctional alkylating agents N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea

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7 January 2021

Formation and persistence of O6-(2-hydroxyethyl)-2' -deoxyguanosine in DNA of various rat tissues following a single dose of N-nitroso-N-(2-hydroxyethyl)urea. An immuno-slot-blot study

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7 January 2021

Evaluation of genetic risks of alkylating agents: tissue doses in the mouse from air contaminated with ethylene oxide

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7 January 2021

The research background for risk assessment of ethylene oxide: aspects of dose.

1 reference

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7 January 2021

Monitoring of environmental cancer initiators through hemoglobin adducts by a modified Edman degradation method

1 reference

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7 January 2021

Monitoring occupational exposure to ethylene oxide by the determination of hemoglobin adducts

1 reference

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7 January 2021

Biological and chemical monitoring of occupational exposure to ethylene oxide

1 reference

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7 January 2021

Biological effect monitoring in industrial workers following incidental exposure to high concentrations of ethylene oxide

1 reference

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7 January 2021

Biomonitoring of exposure to ethylene oxide and propylene oxide by determination of hemoglobin adducts: correlations between airborne exposure and adduct levels

1 reference

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7 January 2021

Quantitative estimation of the genetic risk associated with the induction of heritable translocations at low-dose exposure: ethylene oxide as an example

1 reference

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7 January 2021

Ethylene oxide: evaluation of genotoxicity data and an exploratory assessment of genetic risk

1 reference

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7 January 2021

Assessment of heritable mutations--the parallelogram approach.

1 reference

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7 January 2021

International Commission for Protection Against Environmental Mutagens and Carcinogens. Dosimetry of genotoxic agents and dose-response relationships of their effects

1 reference

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7 January 2021

Measurement of HPRT mutations in splenic lymphocytes and haemoglobin adducts in erythrocytes of Lewis rats exposed to ethylene oxide

1 reference

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7 January 2021

High-performance liquid chromatography versus solid-phase extraction for post-derivatization cleanup prior to gas chromatography-electron-capture negative-ion mass spectrometry of a product derived from an ethylene oxide DNA adduct

1 reference

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7 January 2021

General method for determining ethylene oxide and related N7-guanine DNA adducts by gas chromatography-electron capture mass spectrometry

1 reference

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7 January 2021

Macromolecular adducts of ethylene oxide: a literature review and a time-course study on the formation of 7-(2-hydroxyethyl)guanine following exposures of rats by inhalation

1 reference

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7 January 2021

Degree of alkylation of macromolecules in vivo from variable exposure

1 reference

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7 January 2021

Comparison of ethylene, propylene and styrene 7,8-oxide in vitro adduct formation on N-terminal valine in human haemoglobin and on N-7-guanine in human DNA.

1 reference

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7 January 2021

Alkylation of DNA and hemoglobin in the mouse following exposure to ethene and ethene oxide.

1 reference

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7 January 2021

Cancer risk estimation of genotoxic chemicals based on target dose and a multiplicative model.

1 reference

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7 January 2021

Molecular dosimetry of endogenous and ethylene oxide-induced N7-(2-hydroxyethyl) guanine formation in tissues of rodents

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900208-0

7 January 2021

Endogenous and background DNA adducts by methylating and 2-hydroxyethylating agents

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900208-0

7 January 2021

Molecular dosimetry of DNA and hemoglobin adducts in mice and rats exposed to ethylene oxide

1 reference

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7 January 2021

In vivo mutagenicity of ethylene oxide at the hprt locus in T-lymphocytes of B6C3F1 lacI transgenic mice following inhalation exposure.

1 reference

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7 January 2021

Enhanced hprt mutant frequency but no significant difference in mutation spectrum between a smoking and a non-smoking human population.

1 reference

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7 January 2021

Sister-chromatid exchange induction in peripheral blood lymphocytes of rats exposed to ethylene oxide by inhalation

1 reference

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7 January 2021

Cytogenetic effects of inhaled ethylene oxide in somatic and germ cells of mice

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7 January 2021

In vivo covalent binding of organic chemicals to DNA as a quantitative indicator in the process of chemical carcinogenesis

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7 January 2021

Quantitative evaluation of DNA binding data for risk estimation and for classification of direct and indirect carcinogens

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7 January 2021

Quantitative comparison of carcinogenicity, mutagenicity and electrophilicity of 10 direct-acting alkylating agents and of the initial O6:7-alkylguanine ratio in DNA with carcinogenic potency in rodents.

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7 January 2021

Alkylation of DNA and hemoglobin in the mouse following exposure to propene and propylene oxide

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7 January 2021

Covalent binding of styrene to DNA in rat and mouse

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7 January 2021

Investigation of the covalent binding of styrene-7,8-oxide to DNA in rat and mouse.

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7 January 2021

Unsaturated lipids and intestinal bacteria as sources of endogenous production of ethene and ethylene oxide.

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7 January 2021

Inhalation pharmacokinetics based on gas uptake studies. VI. Comparative evaluation of ethylene oxide and butadiene monoxide as exhaled reactive metabolites of ethylene and 1,3-butadiene in rats

1 reference

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Intestinal bacteria and endogenous production of malonaldehyde and alkylators in mice.

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7 January 2021

A note on the physiological background of the ethylene oxide adduct 7-(2-hydroxyethyl)guanine in DNA from human blood.

1 reference

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7 January 2021

A gas chromatography/electron capture/negative chemical ionization high-resolution mass spectrometry method for analysis of endogenous and exogenous N7-(2-hydroxyethyl)guanine in rodents and its potential for human biological monitoring

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Quantification of endogenous carcinogens. The ethylene oxide paradox

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Proposed changes in the classification of carcinogenic chemicals in the work area.

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7 January 2021

Identifiers

10.1016/S0027-5107(99)00208-0

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10686305%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

PubMed publication ID

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10686305%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

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