(Q73551252)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10718339%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

title

F 11782, a novel epipodophylloid non-intercalating dual catalytic inhibitor of topoisomerases I and II with an original mechanism of action (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10718339%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

author name string

D Perrin

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10718339%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

B van Hille

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10718339%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

J M Barret

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10718339%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

A Kruczynski

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10718339%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

C Etiévant

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10718339%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

T Imbert

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10718339%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

B T Hill

7

1 reference

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4 November 2019

language of work or name

English

0 references

publication date

1 April 2000

1 reference

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4 November 2019

published in

Biochemical Pharmacology

1 reference

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4 November 2019

volume

59

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4 November 2019

issue

7

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4 November 2019

page(s)

807-819

1 reference

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4 November 2019

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Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II.

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Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22

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Novel HeLa topoisomerase II is the II beta isoform: complete coding sequence and homology with other type II topoisomerases.

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Expression, domain structure, and enzymatic properties of an active recombinant human DNA topoisomerase II beta

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Complementation of temperature-sensitive topoisomerase II mutations in Saccharomyces cerevisiae by a human TOP2 beta construct allows the study of topoisomerase II beta inhibitors in yeast

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Essential mitotic functions of DNA topoisomerase IIalpha are not adopted by topoisomerase IIbeta in human H69 cells

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Relationship between expression of topoisomerase II isoforms and intrinsic sensitivity to topoisomerase II inhibitors in breast cancer cell lines

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Differential expression of DNA topoisomerase II alpha and -beta in P-gp and MRP-negative VM26, mAMSA and mitoxantrone-resistant sublines of the human SCLC cell line GLC4.

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Yeast cells expressing differential levels of human or yeast DNA topoisomerase II: a potent tool for identification and characterization of topoisomerase II-targeting antitumour agents

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Discovery of podophyllotoxins

7 January 2021

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Catalytic inhibitors of DNA topoisomerase II

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Mode of action of topoisomerase II-targeting agents at a specific DNA sequence. Uncoupling the DNA binding, cleavage and religation events

7 January 2021

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Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp

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Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage

7 January 2021

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The antileukemic alkaloid fagaronine is an inhibitor of DNA topoisomerases I and II.

7 January 2021

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Antitumor activity of a novel quinoline derivative, TAS-103, with inhibitory effects on topoisomerases I and II.

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7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10718339%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

1 reference