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English
SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression
scientific article published on 01 August 2000
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
11248806
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11248806%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
title
SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
11248806
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11248806%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
main subject
thymocyte
0 references
author
Ann-Muriel Steff
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
11248806
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11248806%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
author name string
Herblot S
series ordinal
1
1 reference
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Europe PubMed Central
PubMed ID
11248806
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11248806%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
Hugo P
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3
1 reference
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Europe PubMed Central
PubMed ID
11248806
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11248806%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
Aplan PD
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4
1 reference
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Europe PubMed Central
PubMed ID
11248806
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11248806%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
Hoang T
series ordinal
5
1 reference
stated in
Europe PubMed Central
PubMed ID
11248806
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11248806%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
publication date
1 August 2000
1 reference
stated in
Europe PubMed Central
PubMed ID
11248806
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11248806%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
published in
Nature Immunology
1 reference
stated in
Europe PubMed Central
PubMed ID
11248806
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11248806%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
volume
1
1 reference
stated in
Europe PubMed Central
PubMed ID
11248806
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11248806%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
page(s)
138-144
1 reference
stated in
Europe PubMed Central
PubMed ID
11248806
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11248806%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
issue
2
1 reference
stated in
Europe PubMed Central
PubMed ID
11248806
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11248806%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
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Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene
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The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages
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Analysis of gene expression in a complex differentiation hierarchy by global amplification of cDNA from single cells.
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The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins
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The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells
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TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3
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Transcription factor SCL is required for c-kit expression and c-Kit function in hemopoietic cells.
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Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice
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Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha.
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An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice
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E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas
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Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors
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Disruption of the human SCL locus by "illegitimate" V-(D)-J recombinase activity
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Control points in early T-cell development
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Characterization of hematopoietic progenitor cells that express the transcription factor SCL, using a lacZ "knock-in" strategy
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Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis
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Positive selection of thymocytes: the long and winding road.
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Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: implications for B-lymphoid-cell development
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Expression of the mouse pre-T cell receptor alpha gene is controlled by an upstream region containing a transcriptional enhancer
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7 January 2021
based on heuristic
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A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines
1 reference
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7 January 2021
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Pre-T cell receptor (TCR) and TCR-controlled checkpoints in T cell differentiation are set by Ikaros
1 reference
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7 January 2021
based on heuristic
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p56lck signals for regulating thymocyte development can be distinguished by their dependency on Rho function
1 reference
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Crossref
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7 January 2021
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Positive and negative regulation of V(D)J recombination by the E2A proteins
1 reference
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reference URL
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7 January 2021
based on heuristic
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Overexpression of the Helix-Loop-Helix protein Id2 blocks T cell development at multiple stages.
1 reference
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Crossref
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7 January 2021
based on heuristic
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Disrupted differentiation and oncogenic transformation of lymphoid progenitors in E2A-HLF transgenic mice
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7 January 2021
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Oncogenic transcription factors in the human acute leukemias
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7 January 2021
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The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene
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7 January 2021
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Regulation of the expression of cyclin-dependent kinase inhibitor p21 by E2A and Id proteins
1 reference
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Thymic overexpression of Ttg-1 in transgenic mice results in T-cell acute lymphoblastic leukemia/lymphoma
1 reference
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Crossref
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7 January 2021
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B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB.
1 reference
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7 January 2021
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Timing of deletion of autoreactive V β6+ cells and down-modulation of either CD4 orCD8 on phenotypically distinct CD4+8+ subsets of thymocytes expressingintermediate or high levels of T cell receptor
1 reference
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Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
1 reference
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A developmental switch from TCR delta enhancer to TCR alpha enhancer function during thymocyte maturation.
1 reference
stated in
Crossref
reference URL
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The SCL gene is formed from a transcriptionally complex locus
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F77819
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7 January 2021
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Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs
1 reference
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Identifiers
DOI
10.1038/77819
1 reference
stated in
Europe PubMed Central
PubMed ID
11248806
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11248806%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
PubMed ID
11248806
1 reference
stated in
Europe PubMed Central
PubMed ID
11248806
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11248806%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
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