Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q73702393)
Watch
English
Conformational diversity and protein evolution--a 60-year-old hypothesis revisited
scientific article published on 01 July 2003
In more languages
edit
Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12878003
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12878003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
title
Conformational diversity and protein evolution--a 60-year-old hypothesis revisited
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12878003
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12878003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
author name string
Leo C James
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12878003
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12878003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
Dan S Tawfik
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12878003
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12878003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
publication date
1 July 2003
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12878003
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12878003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
number of pages
8
1 reference
based on heuristic
inferred from page(s)
published in
Trends in Biochemical Sciences
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12878003
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12878003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
volume
28
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12878003
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12878003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
issue
7
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12878003
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12878003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
page(s)
361-368
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12878003
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12878003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
cites work
Conformational changes affect binding and catalysis by ester-hydrolysing antibodies.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Calculation of ensembles of structures representing the unfolded state of an SH3 domain.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Direct structural evidence for a concerted allosteric transition in Escherichia coli aspartate transcarbamoylase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Two-state allosteric behavior in a single-domain signaling protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An evolutionary bridge to a new protein fold.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Conformational diversity in a yeast prion dictates its seeding specificity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence that the 127-164 region of prion proteins has two equi-energetic conformations with beta or alpha features
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Natively unfolded proteins: a point where biology waits for physics
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intrinsically unstructured proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple conformational changes in enzyme catalysis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dynamic properties of the Ras switch I region and its importance for binding to effectors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Flexibility, conformational diversity and two dimerization modes in complexes of ribosomal protein L12
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Kinetic evidence for hapten-induced conformational transition in immunoglobin MOPC 460
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Equilibrium and rate constants for the interconversion of two conformations of -chymotrypsin. The existence of a catalytically inactive conformation at neutral p H
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antibody multispecificity mediated by conformational diversity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure and dynamics of the alpha-lactalbumin molten globule: fluorescence studies using proteins containing a single tryptophan residue
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Memory landscapes of single-enzyme molecules
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple diverse ligands binding at a single protein site: a matter of pre-existing populations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Catalytic promiscuity and the evolution of new enzymatic activities
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enzymes with extra talents: moonlighting functions and catalytic promiscuity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Off-the-shelf proteins that rival tailor-made antibodies as catalysts.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Substrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The trypanosomal trans-sialidase: two catalytic functions associated with one catalytic site
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural and physicochemical analysis of the reaction between the anti-lysozyme antibody D1.3 and the anti-idiotopic antibodies E225 and E5.2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Man-made enzymes--from design to in vitro compartmentalisation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The search for the ideal biocatalyst.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Biochemical characterization and crystallographic structure of an Escherichia coli protein from the phosphotriesterase gene family
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rapid evolution of bacterial catabolic enzymes: a case study with atrazine chlorohydrolase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enzyme recruitment in evolution of new function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Moonlighting proteins.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evolutionary chemistry: getting there from here
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Plasticity, evolvability, and modularity in RNA
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The protein trinity--linking function and disorder.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Gradual development of protein-like global structures through functional selection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct stages of protein evolution as suggested by protein sequence analysis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vitro evolution of beta-glucuronidase into a beta-galactosidase proceeds through non-specific intermediates
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Directed evolution of a (beta alpha)8-barrel enzyme to catalyze related reactions in two different metabolic pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alteration of Cre recombinase site specificity by substrate-linked protein evolution.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
From Levinthal to pathways to funnels
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A Theory of the Structure and Process of Formation of Antibodies*
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Conformational isomerism and the diversity of antibodies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural insights into the evolution of an antibody combining site
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antibody framework residues affecting the conformation of the hypervariable loops
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900135-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0968-0004(03)00135-X
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12878003
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12878003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
PubMed publication ID
12878003
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12878003
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12878003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit
