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English
Beta-secretase revealed: starting gate for race to novel therapies for Alzheimer's disease
scientific article published on 01 May 2000
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10785643
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10785643%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
title
Beta-secretase revealed: starting gate for race to novel therapies for Alzheimer's disease
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10785643
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10785643%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
main subject
Alzheimer's disease
1 reference
based on heuristic
inferred from title
author name string
D M Skovronsky
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10785643
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10785643%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
V M Lee
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10785643
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10785643%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
publication date
1 May 2000
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10785643
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10785643%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
published in
Trends in Pharmacological Sciences
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10785643
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10785643%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
volume
21
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10785643
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10785643%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
issue
5
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10785643
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10785643%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
page(s)
161-163
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10785643
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10785643%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
cites work
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901467-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901467-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901467-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901467-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901467-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901467-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901467-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901467-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Q22251293
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901467-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901467-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Purification and cloning of amyloid precursor protein beta-secretase from human brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901467-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901467-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901467-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901467-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901467-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901467-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Novel beta-secretase cleavage of beta-amyloid precursor protein in the endoplasmic reticulum/intermediate compartment of NT2N cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901467-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901467-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential effects of the swedish mutant amyloid precursor protein on beta-amyloid accumulation and secretion in neurons and nonneuronal cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901467-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901467-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901467-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0165-6147(00)01467-X
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10785643
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10785643%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
PubMed publication ID
10785643
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10785643
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10785643%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
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