(Q73905120)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10857990%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

title

UCN-01 enhances the in vitro toxicity of clinical agents in human tumor cell lines (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10857990%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

author name string

A Monks

1

1 reference

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7 November 2019

E D Harris

2

1 reference

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7 November 2019

A Vaigro-Wolff

3

1 reference

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7 November 2019

C D Hose

4

1 reference

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7 November 2019

J W Connelly

5

1 reference

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7 November 2019

E A Sausville

6

1 reference

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7 November 2019

publication date

1 May 2000

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10857990%20AND%20SRC:MED&resulttype=core&format=json

Investigational New Drugs

7 November 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10857990%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

volume

18

1 reference

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7 November 2019

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10857990%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

page(s)

95-107

1 reference

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https://scigraph.springernature.com/pub.10.1023/a:1006313611677

7 November 2019

exact match

0 references

cites work

UCN-01 abrogates G2 arrest through a Cdc2-dependent pathway that is associated with inactivation of the Wee1Hu kinase and activation of the Cdc25C phosphatase.

1 reference

12 December 2020

Unpredicted clinical pharmacology of UCN-01 caused by specific binding to human alpha1-acid glycoprotein.

1 reference

12 December 2020

New colorimetric cytotoxicity assay for anticancer-drug screening

1 reference

12 December 2020

Blocking of glioma proliferation in vitro and in vivo and potentiating the effects of BCNU and cisplatin: UCN-01, a selective protein kinase C inhibitor.

1 reference

12 December 2020

UCN-01 in ovary cancer cells: effective as a single agent and in combination with cis-diamminedichloroplatinum(II)independent of p53 status.

1 reference

12 December 2020

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities

1 reference

12 December 2020

A three-dimensional model to analyze drug-drug interactions

1 reference

12 December 2020

Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function

1 reference

12 December 2020

Mammalian G1 and G2 phase checkpoints

1 reference

12 December 2020

The antiviral and synergic actions of isatin thiosemicarbazone and certain phenoxypyrimidines in vaccinia infection in mice

1 reference

12 December 2020

Comparison of effects of bryostatins 1 and 2 and 12-O-tetradecanoylphorbol-13-acetate on protein kinase C activity in A549 human lung carcinoma cells

1 reference

12 December 2020

Differential effects of staurosporine analogues on cell cycle, growth and viability in A549 cells

1 reference

12 December 2020

UCN-01, 7-hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line

1 reference

12 December 2020

Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines

1 reference

12 December 2020

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

1 reference

12 December 2020

Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells

1 reference

12 December 2020

UCN-01, a selective inhibitor of protein kinase C from Streptomyces.

1 reference

12 December 2020

Role of the cdc25C phosphatase in G2 arrest induced by nitrogen mustard

1 reference

12 December 2020

Differing effects of staurosporine and UCN-01 on RB protein phosphorylation and expression of lung cancer cell lines

1 reference

12 December 2020

Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models

1 reference

12 December 2020

Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C

1 reference

12 December 2020

UCN-01 suppresses thymidylate synthase gene expression and enhances 5-fluorouracil-induced apoptosis in a sequence-dependent manner.

1 reference

12 December 2020

The effect of UCN-01 (7-hydroxystaurosporine), a potent inhibitor of protein kinase C, on fractionated radiotherapy or daily chemotherapy of a murine fibrosarcoma

1 reference

12 December 2020

Comparison of ability of protein kinase C inhibitors to arrest cell growth and to alter cellular protein kinase C localisation

1 reference

12 December 2020

Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new G2-checkpoint inhibitor

1 reference

12 December 2020

Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2

1 reference

12 December 2020

7-Hydroxystaurosporine (UCN-01) causes redistribution of proliferating cell nuclear antigen and abrogates cisplatin-induced S-phase arrest in Chinese hamster ovary cells

1 reference

12 December 2020

G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells

1 reference

12 December 2020