(Q73965401)

English

Age-related accumulation of oxidative DNA damage and alterations in levels of p16(INK4a/CDKN2a), p21(WAF1/CIP1/SDI1) and p27(KIP1) in human CD4+ T cell clones in vitro

scientific article published on 01 August 2001

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11389930%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

Age-related accumulation of oxidative DNA damage and alterations in levels of p16(INK4a/CDKN2a), p21(WAF1/CIP1/SDI1) and p27(KIP1) in human CD4+ T cell clones in vitro (English)

1 reference

Europe PubMed Central

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8 November 2019

author name string

P Hyland

1

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8 November 2019

C Barnett

2

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8 November 2019

G Pawelec

3

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8 November 2019

Y Barnett

4

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8 November 2019

publication date

1 August 2001

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8 November 2019

Mechanisms of Ageing and Development

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Europe PubMed Central

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8 November 2019

122

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8 November 2019

11

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8 November 2019

1151-1167

1 reference

Europe PubMed Central

PubMed publication ID

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8 November 2019

The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory

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An investigation of antioxidant status, DNA repair capacity and mutation as a function of age in humans.

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Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA.

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Oxidative DNA damage in human cells: the influence of antioxidants and DNA repair

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Multiple pathways control cell growth and transformation: overlapping and independent activities of p53 and p21Cip1/WAF1/Sdi1.

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7 January 2021

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p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

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Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence

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Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis.

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7 January 2021

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Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?

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WAF1, a potential mediator of p53 tumor suppression

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7 January 2021

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Involvement of the Ink4 proteins p16 and p15 in T-lymphocyte senescence

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Expansion of cytotoxic CD8+ CD28- T cells in healthy ageing people, including centenarians.

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Immune Parameters in a Longitudinal Study of a Very Old Population of Swedish People: A Comparison Between Survivors and Nonsurvivors

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Aging, longevity, and cancer: studies in Down's syndrome and centenarians.

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The immunology of exceptional individuals: the lesson of centenarians.

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7 January 2021

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Long-term in vitro growth of human T cell clones: can postmitotic 'senescent' cell populations be defined?

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7 January 2021

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Levels of peripheral blood cell DNA damage in insulin dependent diabetes mellitus human subjects

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Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

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7 January 2021

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Inhibition of cyclin-dependent kinases by p21

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The serial cultivation of human diploid cell strains

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Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

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An investigation of mutation as a function of age in humans.

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In vivo antioxidant status, DNA damage, mutation and DNA repair capacity in cultured lymphocytes from healthy 75- to 80-year-old humans

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Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution

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7 January 2021

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p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene

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Effect of age on lymphocyte proliferation

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Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a)

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Identifiers

10.1016/S0047-6374(01)00254-8

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11389930%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11389930%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

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