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TNFalpha and leptin inhibit basal and glucose-stimulated insulin secretion and gene transcription in the HIT-T15 pancreatic cells
scientific article published on 01 July 2001
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11443501
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11443501%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
title
TNFalpha and leptin inhibit basal and glucose-stimulated insulin secretion and gene transcription in the HIT-T15 pancreatic cells
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11443501
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11443501%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
author name string
P C Tsiotra
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11443501
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11443501%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
C Tsigos
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11443501
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11443501%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
S A Raptis
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11443501
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11443501%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
publication date
1 July 2001
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11443501
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11443501%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
volume
25
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11443501
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11443501%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
issue
7
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11443501
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11443501%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
page(s)
1018-1026
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11443501
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11443501%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
cites work
Tumor necrosis factor alpha: a key component of the obesity-diabetes link
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
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7 January 2021
based on heuristic
inferred from DOI database lookup
The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanisms of TNF-alpha-induced insulin resistance
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor necrosis factor alpha inhibits signaling from the insulin receptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
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7 January 2021
based on heuristic
inferred from DOI database lookup
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
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7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor necrosis factor alpha-induced phosphorylation of insulin receptor substrate-1 (IRS-1). Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TNF-alpha inhibits glucose-induced insulin secretion in a pancreatic beta-cell line (INS-1).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Positional cloning of the mouse obese gene and its human homologue
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Central nervous system effects of leptin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Leptin--a regulator of islet function?: its plasma levels correlate with glucagon and insulin secretion in healthy women.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of Acute or Prolonged Exposure to Human Leptin on Isolated Human Islet Function
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Leptin inhibits insulin secretion and reduces insulin mRNA levels in rat isolated pancreatic islets
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of the obese gene product on body weight regulation in ob/ob mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Correction of obesity and diabetes in genetically obese mice by leptin gene therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Do leptin receptors play a functional role in the endocrine pancreas?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Leptin stimulates insulin secretion and synthesis in HIT-T 15 cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Direct stimulation of basal insulin secretion by physiological concentrations of leptin in pancreatic beta cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor necrosis factor receptor and Fas signaling mechanisms.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
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7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor necrosis factor-alpha-activated cell death pathways in NIT-1 insulinoma cells and primary pancreatic beta cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
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7 January 2021
based on heuristic
inferred from DOI database lookup
Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
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7 January 2021
based on heuristic
inferred from DOI database lookup
Functional analysis of tumor necrosis factor (TNF) receptors in TNF-alpha-mediated insulin resistance in genetic obesity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
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7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor necrosis factor alpha signaling pathway and apoptosis in pancreatic beta cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
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7 January 2021
based on heuristic
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TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide
1 reference
stated in
Crossref
reference URL
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7 January 2021
based on heuristic
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Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of leptin on insulin secretion from isolated rat pancreatic islets.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Leptin receptors expressed on pancreatic beta-cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Leptin receptor signal transduction: OBRa and OBRb of fa type
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
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7 January 2021
based on heuristic
inferred from DOI database lookup
Divergent signaling capacities of the long and short isoforms of the leptin receptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Direct antidiabetic effect of leptin through triglyceride depletion of tissues.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of fatty acid homeostasis in cells: novel role of leptin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1beta cytotoxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.IJO.0801657
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/SJ.IJO.0801657
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11443501
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11443501%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
PubMed publication ID
11443501
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11443501
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11443501%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
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