(Q7434196)

English

sclerostin

mammalian protein found in Homo sapiens

SOST
uniprot:Q9BQB4
Sclerostin
SOSTDC1 protein, human

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

Cystine-knot cytokine

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9BQB4

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9BQB4

Cystine knot, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transcription factor binding

determination method

1 reference

8 April 2019

Control of the SOST bone enhancer by PTH using MEF2 transcription factors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

determination method

protein binding

determination method

5 references

8 April 2019

Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

determination method

8 April 2019

Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

determination method

8 April 2019

Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

determination method

8 April 2019

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

determination method

8 April 2019

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

determination method

heparin binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

determination method

extracellular matrix

determination method

1 reference

27 February 2018

Proteomics characterization of extracellular space components in the human aorta

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BQB4&geneProductId=UniProtKB:Q9BQB4

determination method

Golgi apparatus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

determination method

protein-containing complex

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

determination method

collagen-containing extracellular matrix

determination method

1 reference

8 April 2019

Proteomics characterization of extracellular space components in the human aorta

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

determination method

biological process

Wnt signaling pathway

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

determination method

negative regulation of BMP signaling pathway

determination method

1 reference

8 April 2019

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

determination method

positive regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Control of the SOST bone enhancer by PTH using MEF2 transcription factors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

determination method

response to mechanical stimulus

determination method

1 reference

8 April 2019

Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

determination method

negative regulation of protein-containing complex assembly

determination method

1 reference

8 April 2019

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

determination method

negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification

determination method

1 reference

27 February 2018

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BQB4&geneProductId=UniProtKB:Q9BQB4

determination method

cellular response to parathyroid hormone stimulus

determination method

1 reference

8 April 2019

Control of the SOST bone enhancer by PTH using MEF2 transcription factors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

determination method

negative regulation of ossification

determination method

3 references

8 April 2019

Control of the SOST bone enhancer by PTH using MEF2 transcription factors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

determination method

8 April 2019

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

determination method

http://purl.uniprot.org/uniprot/Q9BQB4

1 reference

Identifiers.org

Cystine knot, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9BQB4

Identifiers

MeSH descriptor ID

subject named as

SOSTDC1 protein, human

0 references

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000301691

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000301691

PDB structure ID

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

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Wiktionary(0 entries)

Multilingual sites(0 entries)

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