(Q74497607)

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Modulation of DNA repair by various inhibitors of DNA synthesis following 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induced DNA damage

scientific article published on 01 March 1998

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scholarly article

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11 November 2019

Modulation of DNA repair by various inhibitors of DNA synthesis following 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induced DNA damage (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9566722%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

author name string

J F Cloutier

1

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11 November 2019

A Castonguay

2

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11 November 2019

publication date

1 March 1998

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11 November 2019

Chemico-biological Interactions

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11 November 2019

110

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11 November 2019

1-2

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11 November 2019

7-25

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11 November 2019

Tobacco-specific nitrosamines in Canadian cigarettes.

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Metabolic activation and detoxification of tobacco-specific nitrosamines--a model for cancer prevention strategies

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Pharmacokinetics of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in laboratory animals

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7 January 2021

Evidence for 4-(3-pyridyl)-4-oxobutylation of DNA in F344 rats treated with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine.

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Increased 8-oxodeoxyguanosine levels in lung DNA of A/J mice and F344 rats treated with the tobacco-specific nitrosamine 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone.

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7 January 2021

In vivo and in vitro persistence of pyridyloxobutyl DNA adducts from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

1 reference

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7 January 2021

Investigations of metabolic precursors to hemoglobin and DNA adducts of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

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7 January 2021

The detection of various nitrosamines in the hepatocyte primary culture/DNA repair test

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7 January 2021

Lack of correlation between DNA methylation and hepatocarcinogenesis in rats and hamsters treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

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7 January 2021

Extent of formation of O4-methylthymidine in calf thymus DNA methylated by N-methyl-N-nitrosourea and lack of repair of this product by rat liver O6-alkylguanine-DNA-alkyltransferase.

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7 January 2021

Enzymatic release of 7-methylguanine from methylated DNA by rodent liver extracts

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7 January 2021

Comprehensive analysis of urinary metabolites of N'-nitrosonornicotine

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7 January 2021

Phenobarbital induction of cytochromes P-450. High-level long-term responsiveness of primary rat hepatocyte cultures to drug induction, and glucocorticoid dependence of the phenobarbital response

1 reference

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7 January 2021

The effects of putative DNA repair inhibitors on DNA adduct levels and unscheduled DNA synthesis in rat hepatocytes exposed to 2-acetylaminofluorene

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7 January 2021

DNA repair induced by various mutagens in rat hepatocyte primary cultures measured in the presence of hydroxyurea, guanazole or aphidicolin.

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7 January 2021

The function of DNA topoisomerases in UV-induced DNA excision repair: studies with specific inhibitors in permeabilized human fibroblasts

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7 January 2021

Unscheduled DNA synthesis of rat hepatocytes in monolayer culture

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7 January 2021

The effect of nicotinamide on unscheduled DNA synthesis in cultured hepatocytes

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7 January 2021

A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid

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7 January 2021

Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by inducible and constitutive cytochrome P450 enzymes in rats

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7 January 2021

Influence of extracellular matrix overlay on phenobarbital-mediated induction of CYP2B1, 2B2, and 3A1 genes in primary adult rat hepatocyte culture

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7 January 2021

Structure-activity relationships in the rat hepatocyte DNA-repair test for 300 chemicals

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7 January 2021

Improved sensitivity of the unscheduled DNA synthesis assay in primary rat hepatocytes following culture in serum-free defined media

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7 January 2021

Evaluation of the alkaline elution/rat hepatocyte assay as a predictor of carcinogenic/mutagenic potential.

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7 January 2021

Effects of alpha-deuterium substitution on the mutagenicity of 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

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7 January 2021

Effect of nalidixic acid on DNA repair in rat hepatocytes

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7 January 2021

Action of etoposide (VP-16-123) on human cells: no evidence for topoisomerase II involvement in excision repair of u.v.-induced DNA damage, nor for mitochondrial hypersensitivity in ataxia telangiectasia

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7 January 2021

DNA topoisomerases and DNA repair

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7 January 2021

Direct inhibition of u.v.-induced DNA excision repair in human cells by novobiocin, coumermycin and nalidixic acid

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7 January 2021

A critical review of permeabilized cell systems for studying mammalian DNA repair

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7 January 2021

New views of the biochemistry of eucaryotic DNA replication revealed by aphidicolin, an unusual inhibitor of DNA polymerase alpha

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7 January 2021

The inhibition of DNA repair in primary rat hepatocyte cultures by aphidicolin: evidence for the involvement of alpha polymerase in the repair process

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7 January 2021

Regulation of DNA ligase activity by poly(ADP-ribose)

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7 January 2021

Enhanced ligation of repair sites under conditions of inhibition of poly(ADP-ribose) synthesis by 3-aminobenzamide

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7 January 2021

3-Aminobenzamide stimulates unscheduled DNA synthesis and rejoining of strand breaks in human lymphocytes

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7 January 2021

Inhibition of (ADP-ribose)n biosynthesis retards DNA repair but does not inhibit DNA repair synthesis

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Role of poly(ADP-ribose) formation in DNA repair

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Identifiers

10.1016/S0009-2797(97)00114-2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9566722%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9566722%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

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