(Q77309932)

English

Vinflunine (20',20'-difluoro-3',4'-dihydrovinorelbine), a novel Vinca alkaloid, which participates in P-glycoprotein (Pgp)-mediated multidrug resistance in vivo and in vitro

scientific article published on 01 January 1998

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9740539%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

Vinflunine (20',20'-difluoro-3',4'-dihydrovinorelbine), a novel Vinca alkaloid, which participates in P-glycoprotein (Pgp)-mediated multidrug resistance in vivo and in vitro (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9740539%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

multiple drug resistance

1 reference

based on heuristic

author name string

C Etievant

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9740539%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

J M Barret

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9740539%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

A Kruczynski

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9740539%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

D Perrin

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9740539%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

B T Hill

5

1 reference

Europe PubMed Central

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4 December 2019

publication date

1 January 1998

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9740539%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

Investigational New Drugs

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9740539%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

16

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9740539%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9740539%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

3-17

1 reference

Europe PubMed Central

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4 December 2019

https://scigraph.springernature.com/pub.10.1023/a:1006022811895

0 references

Alterations of vinblastine influx in multidrug-resistant lymphoblastic leukaemic CEM cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

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Fluorinated colchicinoids: antitubulin and cytotoxic properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

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Mechanisms of multidrug resistance in human tumor cells. The roles of P-glycoprotein, DNA topoisomerase II, and other factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

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P-glycoprotein as multidrug transporter: a critical review of current multidrug resistant cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

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Comparative study of in vivo development of resistance to various classes of antitumor agents in P388 leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

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Multidrug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

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Altered catalytic activity of and DNA cleavage by DNA topoisomerase II from human leukemic cells selected for resistance to VM-26.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

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Functional role of phosphorylation of the multidrug transporter (P-glycoprotein) by protein kinase C in multidrug-resistant MCF-7 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

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Reduced DNA topoisomerase II activity and drug-induced DNA cleavage activity in an adriamycin-resistant human small cell lung carcinoma cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

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P-glycoprotein expression in malignant lymphoma and reversal of clinical drug resistance with chemotherapy plus high-dose verapamil

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

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Overexpression of P-glycoprotein and alterations in topoisomerase II in P388 mouse leukemia cells selected in vivo for resistance to mitoxantrone

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antimitotic and tubulin-interacting properties of vinflunine, a novel fluorinated Vinca alkaloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential cytotoxic effects of docetaxel in a range of mammalian tumor cell lines and certain drug resistant sublines in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

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Digital cell image analysis of verapamil-induced effects in chemosensitive and chemoresistant neoplastic cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Why haven't we cured multidrug resistant tumors?

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I and pharmacological study of CI-980, a novel synthetic antimicrotubule agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical in vivo antitumor activity of vinflunine, a novel fluorinated Vinca alkaloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-P-glycoprotein-mediated multidrug resistance in a small cell lung cancer cell line: evidence for decreased susceptibility to drug-induced DNA damage and reduced levels of topoisomerase II.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differing patterns of cross-resistance resulting from exposures to specific antitumour drugs or to radiation in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-cancer drug characterisation using a human cell line panel representing defined types of drug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemistry of multidrug resistance mediated by the multidrug transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis and chemotherapy resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the Glutathione Redox Cycle in Acquired and de Novo Multidrug Resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo characteristics of resistance and cross-resistance of an adriamycin-resistant subline of P388 leukemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-glycoprotein mediated resistance to 5'-nor-anhydro-vinblastine (Navelbine)

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione S-transferases. The first enzymatic step in mercapturic acid formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multidrug resistance in a human small cell lung cancer cell line selected in adriamycin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms by which mammalian cells acquire resistance to drugs that affect microtubule assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I trial and pharmacokinetics of the tubulin inhibitor 1069C85--a synthetic agent binding at the colchicine site designed to overcome multidrug resistance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of multidrug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In situ selection of a human rhabdomyosarcoma resistant to vincristine with altered beta-tubulins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

UKCCCR guidelines for the welfare of animals in experimental neoplasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multidrug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How cancer cells evade chemotherapy: sixteenth Richard and Hinda Rosenthal Foundation Award Lecture.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance-associated factors in human small-cell lung-carcinoma GLC4 sub-lines with increasing adriamycin resistance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Establishment of Vincristine-resistant and vindesine-resistant lines of murine lymphoblasts in vitro and characterisation of their patterns of cross-resistance and drug sensitivities

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel mechanism of resistance to paclitaxel (Taxol) in human K562 leukemia cells by combined selection with PSC 833.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multifactorial resistance to adriamycin: relationship of DNA repair, glutathione transferase activity, drug efflux, and P-glycoprotein in cloned cell lines of adriamycin-sensitive and -resistant P388 leukemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multidrug resistance mediated by the multidrug resistance protein (MRP) gene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance to cytostatic drugs at the cellular level

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The nitrogen of the acetamido group of colchicine modulates P-glycoprotein-mediated multidrug resistance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Digital morphonuclear analyses of sensitive versus resistant neoplastic cells to vinca-alkaloid, alkylating, and intercalating drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical and Clinical Pharmacology of Vinca Alkaloids

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical effects of the vinca alkaloids. 3. The synthesis of ribonucleic acid and the incorporation of amino acids in Ehrlich ascites cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of the M(r) 190,000 multidrug resistance protein, MRP, with monoclonal antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug resistance, illustration of the complexity of translational research. Steiner Award lecture 1995.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation of biologic data with physico-chemical properties among the Vinca alkaloids and their congeners

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A 190-kilodalton protein overexpressed in non-P-glycoprotein-containing multidrug-resistant cells and its relationship to the MRP gene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical drug development: rationale and methods

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of four drug-resistant P388 sublines: resistance/sensitivity in vivo, resistance-and proliferation-markers, immunogenicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complete reversal by thaliblastine of 490-fold adriamycin resistance in multidrug-resistant (MDR) human breast cancer cells. Evidence that multiple biochemical changes in MDR cells need not correspond to multiple functional determinants for drug res

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental reversal of P-glycoprotein-mediated multidrug resistance by pharmacological chemosensitisers

1 reference

https://pubmed.ncbi.nlm.nih.gov/9740539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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