(Q77337873)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9750025%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

review article

1 reference

title

Clinical evaluation of biologically targeted drugs: obstacles and opportunities (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9750025%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

author name string

A L Boral

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9750025%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

S Dessain

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9750025%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

B A Chabner

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9750025%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

publication date

1 January 1998

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9750025%20AND%20SRC:MED&resulttype=core&format=json

Cancer Chemotherapy and Pharmacology

4 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9750025%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

volume

42 Suppl

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9750025%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

page(s)

S3-21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9750025%20AND%20SRC:MED&resulttype=core&format=json

Conversion of highly malignant colon cancer from an aggressive to a controlled disease by oral administration of a metalloproteinase inhibitor

4 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Transmural Coupling of Fluid Flow in Microcirculatory Network and Interstitium in Tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Novel methods for the determination of the angiogenic activity of human tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

From bench top to bedside

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Selective cytotoxicity to human leukemic myeloblasts produced by oligodeoxyribonucleotide phosphorothioates complementary to p53 nucleotide sequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Reversal of multiple drug resistance in vitro by phosphorothioate oligonucleotides and ribozymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Phase I trial of an antisense oligonucleotide OL(1)p53 in hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Structure and function of telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Prevalence of ras gene mutations in human colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Microvessel quantitation and prognosis in invasive breast carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Angiogenesis as a marker of preneoplastic lesions of the human breast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Changing views of the role of matrix metalloproteinases in metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Antisense oligonucleotides demonstrate a dominant role of c-Ki-RAS proteins in regulating the proliferation of diploid human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Protein kinase A-directed antisense restrains cancer growth: sequence-specific inhibition of gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Therapeutic Applications of Oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Thalidomide is an inhibitor of angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Inhibition of protein kinase C-alpha expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Effect of cisplatin and c-myb antisense phosphorothioate oligodeoxynucleotides combination on a human colon carcinoma cell line in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Telomerase activity in female and male rat germ cells undergoing meiosis and in early embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Interferon alfa-2a therapy for life-threatening hemangiomas of infancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Human telomerase inhibition by 7-deaza-2'-deoxypurine nucleoside triphosphates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Involvement of integrins alpha v beta 3 and alpha v beta 5 in ocular neovascular diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Ras C-terminal processing enzymes--new drug targets?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Farnesyltransferase inhibitors and anti-Ras therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Neovascularization induced by intraocular xenografts of normal, preneoplastic, and neoplastic mouse mammary tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

All ras proteins are polyisoprenylated but only some are palmitoylated

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Telomeres shorten during ageing of human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Telomerase, Cell Immortality, and Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

A mammalian telomerase-associated protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Telomere reduction in human colorectal carcinoma and with ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

A putative angiogenin receptor in angiogenin-responsive human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

A theoretical study of quantitative flow measurements with constant infusion of short-lived isotopes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Expression of bcl-2 oncogene protein is prevalent in small cell lung carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Clinical application of 18F-FUdR in glioma patients--PET study of nucleic acid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Hammerhead ribozyme-mediated inhibition of telomerase activity in extracts of human hepatocellular carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Suppression of the tumorigenic and metastatic abilities of murine B16-F10 melanoma cells in vivo by the overexpression of the tissue inhibitor of the metalloproteinases-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Antitumor effect of c-myc antisense phosphorothioate oligodeoxynucleotides on human melanoma cells in vitro and and in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Reverse transcriptase motifs in the catalytic subunit of telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Modulation of multidrug resistance gene (mdr-1) with antisense oligodeoxynucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

A phase I study of pentosan polysulfate sodium in patients with advanced malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Tumour angiogenesis and tumour cell proliferation as prognostic indicators in gastric carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Interleukin-12 inhibits angiogenesis induced by human tumor cell lines in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

A hexameric phosphorothioate oligonucleotide telomerase inhibitor arrests growth of Burkitt's lymphoma cells in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

CAAX peptidomimetic FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of phosphatidylinositol 3-kinase but not mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

In vivo diagnosis of human malignant melanoma with positron emission tomography using specific melanoma-seeking 18F-DOPA analogue

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Unfarnesylated transforming Ras mutant inhibits the Ras-signaling pathway by forming a stable Ras.Raf complex in the cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Enhancement of sensitivity of urinary bladder tumor cells to cisplatin by c-myc antisense oligonucleotide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Nuclease resistance and antisense activity of modified oligonucleotides targeted to Ha-ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Effect of transvascular fluid exchange on pressure-flow relationship in tumors: a proposed mechanism for tumor blood flow heterogeneity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Expression in non-Hodgkin's lymphoma of the bcl-2 protein associated with the t(14;18) chromosomal translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Endostatin: an endogenous inhibitor of angiogenesis and tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Angiostatin induces and sustains dormancy of human primary tumors in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Tumor angiogenesis: tutorial on implications for imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Evaluation of bcl-2 protein expression and 14;18 translocation as prognostic markers in follicular lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Brain tumors: L-[1-C-11]tyrosine PET for visualization and quantification of protein synthesis rate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Telomerase activity concentrates in the mitotically active segments of human hair follicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Regulation of the activity of a new inhibitor of angiogenesis by a cancer suppressor gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Acute changes in glucose uptake after treatment: the effects of carmustine (BCNU) on human glioblastoma multiforme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Rodent pharmacokinetic and anti-tumor efficacy studies with a series of synthetic inhibitors of matrix metalloproteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Rational design of Ras prenyltransferase inhibitors as potential anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Telomerase as a potential molecular target to study G-quartet phosphorothioates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Growth Inhibition of Murine Melanoma and Human Colon Carcinoma by Recombinant Human Platelet Factor 4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

A survey of telomerase activity in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Inhibition of thymocyte apoptosis and negative antigenic selection in bcl-2 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Suppression of Philadelphia1 leukemia cell growth in mice by BCR-ABL antisense oligodeoxynucleotide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Antisense oligonucleotides inhibit vascular endothelial growth factor/vascular permeability factor expression in normal human epidermal keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Antisense oligonucleotides as therapeutic agents--is the bullet really magical?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Haemangiomatosis in children: value of MRI during therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Selective Inhibition of Leukemia Cell Proliferation by BCR-ABL Antisense Oligodeoxynucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Mammary carcinoma model: correlation of macromolecular contrast-enhanced MR imaging characterizations of tumor microvasculature and histologic capillary density

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Control of telomere length by the human telomeric protein TRF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Inhibition of angiogenesis in vivo by interleukin 12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Soluble E-selectin in cancer patients as a marker of the therapeutic efficacy of CM101, a tumor-inhibiting anti-neovascularization agent, evaluated in phase I clinical trail

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

A monoclonal antibody detects heterogeneity in vascular endothelium of tumours and normal tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

BCL-2 antisense therapy in patients with non-Hodgkin lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

An information-intensive approach to the molecular pharmacology of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

The DNA structures at the ends of eukaryotic chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Regulated expression of telomerase activity in human T lymphocyte development and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Treatment of pulmonary hemangiomatosis with recombinant interferon alfa-2a

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

The p21 ras C-terminus is required for transformation and membrane association

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Phase I trial of a novel matrix metalloproteinase inhibitor batimastat (BB-94) in patients with advanced cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Matrix metalloproteinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Reverse transcriptase inhibitors suppress telomerase function and induce senescence-like processes in cultured mouse fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Telomerase activity of normal tissues and neoplasms in rat colon carcinogenesis induced by methylazoxymethanol acetate and its difference from that of human colonic tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075

Induction of Apoptosis in Small-Cell Lung Cancer Cells by an Antisense Oligodeoxynucleotide Targeting the Bcl-2 Coding Sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS002800051075