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Abnormal levels and minimal activity of the dsRNA-activated protein kinase, PKR, in breast carcinoma cells
scientific article published on 01 January 1999
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1 reference
stated in
Europe PubMed Central
PubMed ID
10216952
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10216952%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
title
Abnormal levels and minimal activity of the dsRNA-activated protein kinase, PKR, in breast carcinoma cells
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
10216952
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10216952%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
main subject
breast carcinoma
1 reference
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inferred from title
author name string
O Savinova
series ordinal
1
1 reference
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Europe PubMed Central
PubMed ID
10216952
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10216952%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
B Joshi
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
10216952
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10216952%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
R Jagus
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed ID
10216952
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10216952%20AND%20SRC:MED&resulttype=core&format=json
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5 December 2019
publication date
1 January 1999
1 reference
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Europe PubMed Central
PubMed ID
10216952
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10216952%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
published in
International Journal of Biochemistry & Cell Biology
1 reference
stated in
Europe PubMed Central
PubMed ID
10216952
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10216952%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
volume
31
1 reference
stated in
Europe PubMed Central
PubMed ID
10216952
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10216952%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
page(s)
175-189
1 reference
stated in
Europe PubMed Central
PubMed ID
10216952
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10216952%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
issue
1
1 reference
stated in
Europe PubMed Central
PubMed ID
10216952
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10216952%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
cites work
The double-stranded RNA-dependent protein kinase PKR: structure and function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The regulation of the protein kinase PKR by RNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Initiation of protein synthesis in eukaryotic cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The apoptosis pathway triggered by the interferon-induced protein kinase PKR requires the third basic domain, initiates upstream of Bcl-2, and involves ICE-like proteases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PKR, apoptosis and cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain I can act as transdominant inhibitors and induce malignant transformation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular mechanisms responsible for malignant transformation by regulatory and catalytic domain variants of the interferon-induced enzyme RNA-dependent protein kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The 58-kilodalton inhibitor of the interferon-induced double-stranded RNA-activated protein kinase is a tetratricopeptide repeat protein with oncogenic properties
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of p68 protein kinase as recognized by the monoclonal antibody TJ4C4 during human fetal development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of the double-stranded RNA-dependent protein kinase (p68) in squamous cell carcinoma of the head and neck region
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Correlation of the expression of double-stranded RNA-dependent protein kinase (p68) with differentiation in head and neck squamous cell carcinoma.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Elevated apoptotic cell population in patients with chronic fatigue syndrome: the pivotal role of protein kinase RNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of p68 in human colon cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interferon-responsive protein kinase (p68) and proliferating cell nuclear antigen are inversely distributed in head and neck squamous cell carcinoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of the double-stranded RNA-dependent protein kinase (p68) in human breast tissues.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Influenza virus regulates protein synthesis during infection by repressing autophosphorylation and activity of the cellular 68,000-Mr protein kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The cellular 68,000-Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Use of vertical slab isoelectric focusing and immunoblotting to evaluate steady-state phosphorylation of eIF2 alpha in cultured cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Elevated levels of eukaryotic translation initiation factor eIF-4E, mRNA in a broad spectrum of transformed cell lines
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2 alpha in response to growth induction by c-myc
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deregulation of protein synthesis as a mechanism of neoplastic transformation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Upregulated expression of the genes encoding translation initiation factors eIF-4E and eIF-2alpha in transformed cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nuclear localization of the interferon-inducible protein kinase PKR in human cells and transfected mouse cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Simian virus 40 large-T bypasses the translational block imposed by the phosphorylation of elF-2 alpha
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The interferon-inducible protein kinase PKR modulates the transcriptional activation of immunoglobulin kappa gene.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of the double-stranded-RNA-activated protein kinase and induction of vascular cell adhesion molecule-1 by poly (I).poly (C) in endothelial cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Modulation of interferon (IFN)-inducible gene expression by retinoic acid. Up-regulation of STAT1 protein in IFN-unresponsive cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of mutations in stem and loop regions on the structure and function of adenovirus VA RNAI
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional expression and characterization of the interferon-induced double-stranded RNA activated P68 protein kinase from Escherichia coli
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction of adenovirus VA RNAl with the protein kinase DAI: nonequivalence of binding and function.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparative analysis of the regulation of the interferon-inducible protein kinase PKR by Epstein-Barr virus RNAs EBER-1 and EBER-2 and adenovirus VAI RNA
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of the apical stem in maintaining the structure and function of adenovirus virus-associated RNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteins that interact with PKR.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Purification and partial characterization of a cellular inhibitor of the interferon-induced protein kinase of Mr 68,000 from influenza virus-infected cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cellular inhibitors of the interferon-induced, dsRNA-activated protein kinase.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction of the interferon-induced PKR protein kinase with inhibitory proteins P58IPK and vaccinia virus K3L is mediated by unique domains: implications for kinase regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The molecular chaperone hsp40 regulates the activity of P58IPK, the cellular inhibitor of PKR.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The eukaryotic initiation factor 2-associated 67-kDa polypeptide (p67) plays a critical role in regulation of protein synthesis initiation in animal cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Partial characterization of a cellular factor that regulates the double-stranded RNA-dependent eIF-2 alpha kinase in 3T3-F442A fibroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitor of Interferon-Induced Double-Stranded RNA- Dependent Protein Kinase and Its Relevance to Alteration of Cellular Protein Kinase Activity Level in Response to External Stimuli
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enhancement of the interferon-induced double-stranded RNA-dependent protein kinase activity by Sindbis virus infection and heat-shock stress
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Endogenous inhibitors of the dsRNA-dependent eIF-2 alpha protein kinase PKR in normal and ras-transformed cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin 3 stimulates protein synthesis by regulating double-stranded RNA-dependent protein kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Translational control of p27Kip1 accumulation during the cell cycle
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Association of human cyclin E with a periodic G1-S phase protein kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitors of mammalian G1 cyclin-dependent kinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Overexpression of C/EBPbeta-LIP, a naturally occurring, dominant-negative transcription factor, in human breast cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
LAP (NF-IL-6), a tissue-specific transcriptional activator, is an inhibitor of hepatoma cell proliferation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of the bcl-2 gene family in normal and malignant breast tissue: low bax-alpha expression in tumor cells correlates with resistance towards apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Translational regulation of yeast GCN4. A window on factors that control initiator-trna binding to the ribosome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Balancing cell life and death: bax, apoptosis, and breast cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-2725%2898%2900140-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1357-2725(98)00140-X
1 reference
stated in
Europe PubMed Central
PubMed ID
10216952
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10216952%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
PubMed ID
10216952
1 reference
stated in
Europe PubMed Central
PubMed ID
10216952
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10216952%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
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