(Q77596575)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9827573%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

review article

1 reference

title

Innovative treatment programs against cancer. I. Ras oncoprotein as a molecular target (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9827573%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

2

F M Uckun

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9827573%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

author name string

K G Waddick

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9827573%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

language of work or name

English

0 references

publication date

1 December 1998

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9827573%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

published in

Biochemical Pharmacology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9827573%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

volume

56

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9827573%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9827573%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

page(s)

1411-1426

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9827573%20AND%20SRC:MED&resulttype=core&format=json

Cellular ras activity is required for passage through multiple points of the G0/G1 phase in BALB/c 3T3 cells

6 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Mitogenic activation of the Ras guanine nucleotide exchange factor in NIH 3T3 cells involves protein tyrosine phosphorylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Selective inhibition of the growth of ras-transformed human bronchial epithelial cells by emodin, a protein-tyrosine kinase inhibitor.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

The MAPK signaling cascade

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Superoxides relay Ras protein's oncogenic message

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

PI3K signal and DNA repair: a short commentary

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

The activation of phosphatidylinositol 3-kinase by Ras

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Structure-activity relationships of cysteine-lacking pentapeptide derivatives that inhibit ras farnesyltransferase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Suppression of human pancreatic cancer growth in BALB/c nude mice by manumycin, a farnesyl:protein transferase inhibitor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Modulation of azoxymethane-induced mutational activation of ras protooncogenes by chemopreventive agents in colon carcinogenesis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

The 96 kDa protein kinase activated by oncogenic Ras in Xenopus egg extracts is also activated by constitutively active Mek: activation requires serine/threonine phosphorylation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Desensitization of Ras activation by a feedback disassociation of the SOS-Grb2 complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

EGF induced SOS phosphorylation in PC12 cells involves P90 RSK-2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Biology of the Rap proteins, members of the ras superfamily of GTP-binding proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Regulation of Ras-mediated signalling: more than one way to skin a cat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Insulin and epidermal growth factor stimulate a conformational change in Rap1 and dissociation of the CrkII-C3G complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Selective modulation of protein kinase C-theta during T-cell activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Enhanced activity of an antisense oligonucleotide targeting murine protein kinase C-alpha by the incorporation of 2'-O-propyl modifications

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Inhibition of protein kinase C-alpha expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

p21ras as a common signaling target of reactive free radicals and cellular redox stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Ras farnesyltransferase inhibitors suppress the phenotype resulting from an activated ras mutation in Caenorhabditis elegans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Disruption of Oncogenic K-Ras4B Processing and Signaling by a Potent Geranylgeranyltransferase I Inhibitor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

A non-peptide mimetic of Ras-CAAX: selective inhibition of farnesyltransferase and Ras processing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Isoprenoid diphosphate utilization by recombinant human farnesyl:protein transferase: interactive binding between substrates and a preferred kinetic pathway.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Substitution of cadmium for zinc in farnesyl:protein transferase alters its substrate specificity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Alpha-subunit of farnesyltransferase is phosphorylated in vivo: effect of protein phosphatase-1 on enzymatic activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Inhibition of cell growth of human hepatoma cell line (Hep G2) by a farnesyl protein transferase inhibitor: a preferential suppression of ras farnesylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Identification of Ras farnesyltransferase inhibitors by microbial screening

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Oreganic acid, a potent inhibitor of ras farnesyl-protein transferase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Barceloneic acid A, a new farnesyl-protein transferase inhibitor from a Phoma species

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Andrastin D, novel protein farnesyltransferase inhibitor produced by Penicillium sp. FO-3929

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

RPR113228, a novel farnesyl-protein transferase inhibitor produced by Chrysosporium lobatum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Stereospecific synthesis of a novel farnesyl protein transferase inhibitor, valinoctin A and its analogues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

A simple and efficient synthesis of the ras farnesyl-protein transferase inhibitor chaetomellic acid A

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Farnesyl diphosphate-based inhibitors of Ras farnesyl protein transferase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Synergy between anions and farnesyldiphosphate competitive inhibitors of farnesyl:protein transferase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Farnesyl-derived inhibitors of ras farnesyl transferase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Pepticinnamins, new farnesyl-protein transferase inhibitors produced by an actinomycete. II. Structural elucidation of pepticinnamin E

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Synthesis and conformational analysis of peptide inhibitors of farnesyltransferase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Synthesis and biological activity of semipeptoid farnesyltransferase inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Pseudopeptide inhibitors of Ras farnesyl-protein transferase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Inhibitors of anchorage-independent growth affect the growth of transformed cells on poly(2-hydroxyethyl methacrylate)-coated surfaces

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Benzodiazepine peptidomimetic inhibitors of farnesyltransferase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Design and synthesis of non-peptide Ras CAAX mimetics as potent farnesyltransferase inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

A fluorescence assay for geranylgeranyl transferase type I.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

VEGF mRNA is stabilized by ras and tyrosine kinase oncogenes, as well as by UV radiation--evidence for divergent stabilization pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Phosphinyl acid-based bisubstrate analog inhibitors of Ras farnesyl protein transferase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

The inhibition of protein prenyltransferases by oxygenated metabolites of limonene and perillyl alcohol

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Geranylgeraniol potentiates lovastatin inhibition of oncogenic H-Ras processing and signaling while preventing cytotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Cytotoxicity of simvastatin to pancreatic adenocarcinoma cells containing mutant ras gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Modulation of the mevalonate pathway and cell growth by pravastatin and d-limonene in a human hepatoma cell line (Hep G2)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Enhancement of paclitaxel activity against hormone-refractory prostate cancer cells in vitro and in vivo by quinacrine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Hypersensitivity of NIH3T3 cells transformed by H-ras gene to DNA-topoisomerase-I inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Increased radioresistance of EJras-transformed human osteosarcoma cells and its modulation by lovastatin, an inhibitor of p21ras isoprenylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Tumor resistance to oxidative stress: association with ras oncogene expression and reversal by lovastatin, an inhibitor of p21ras isoprenylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Lovastatin inhibits pancreatic cancer growth regardless of RAS mutation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

Inhibition of tumor cell growth by monoterpenes in vitro: evidence of a Ras-independent mechanism of action.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900211-1

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0006-2952(98)00211-1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9827573%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

1 reference