(Q77654041)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9845091%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

title

Bioreductive therapies: an overview of drugs and their mechanisms of action (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9845091%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

author name string

A M Rauth

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9845091%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

T Melo

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9845091%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

V Misra

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9845091%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

language of work or name

English

0 references

publication date

1 November 1998

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9845091%20AND%20SRC:MED&resulttype=core&format=json

International Journal of Radiation Oncology Biology Physics

7 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9845091%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

volume

42

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9845091%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9845091%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

page(s)

755-762

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9845091%20AND%20SRC:MED&resulttype=core&format=json

Chemical modifiers of cancer treatment

7 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

The reduction of Furacin by cell-free extracts of Furacin-resistant and parent-susceptible strains of Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

MITOMYCINS AND PORFIROMYCIN: CHEMICAL MECHANISM OF ACTIVATION AND CROSS-LINKING OF DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

In vivotesting of hypoxic radiosensitizers using the KHT murine tumour assayed by the lung-colony technique

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

Hypoxic Sensitizers: Radiobiological Studies at the Cellular Level

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

Radiosensitizing and toxic effects on the 2-nitroimidazole Ro-07-0582 in hypoxic mammation cells

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

Preparation, toxicity and mutagenicity of 1-methyl-2-nitrosoimidazole. A toxic 2-nitroimidazole reduction product

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

Nitroimidazoles and imaging hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

Measuring Tumor Hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

Adaptation of human tumor cells to tirapazamine under aerobic conditions: implications of increased antioxidant enzyme activity to mechanism of aerobic cytotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

2,4-dinitro-5-ethyleneiminobenzamide (CB 1954): a potent and selective inhibitor of the growth of the Walker carcinoma 256.

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

The nitroreductase enzyme in walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT).

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

The bystander effect of the nitroreductase/CB1954 enzyme/prodrug system is due to a cell-permeable metabolite

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

Prodrugs in cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--II. A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

The differential cytotoxicity of RSU 1069: cell survival studies indicating interaction with DNA as a possible mode of action

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

Assessing the bioreductive effectiveness of the nitroimidazole RSU1069 and its prodrug RB6145: with particular reference to in vivo methods of evaluation

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

Bioreducible mustards: a paradigm for hypoxia-selective prodrugs of diffusible cytotoxins (HPDCs).

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

Platinum complexes with one radiosensitizing ligand [PtCl2(NH3) (sensitizer)]: radiosensitization and toxicity studies in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

Selective toxicity of nitracrine to hypoxic mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

5-Nitro-4-(N,N-dimethylaminopropylamino)quinoline (5-nitraquine), a new DNA-affinic hypoxic cell radiosensitizer and bioreductive agent: comparison with nitracrine

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

NLA-1 : A 2-nitroimidazole radiosensitizer targeted to DNA by intercalation

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

DNA-targeted 2-nitroimidazoles: in vitro and in vivo studies

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

Rationale for the use of aliphatic N-oxides of cytotoxic anthraquinones as prodrug DNA binding agents: a new class of bioreductive agent

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

DNA topoisomerase II-dependent cytotoxicity of alkylaminoanthraquinones and their N-oxides

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

Development, pharmacology, role of DT-diaphorase and prospects of the indoloquinone EO9.

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

Involvement of DT-diaphorase (EC 1.6.99.2) in the DNA cross-linking and sequence selectivity of the bioreductive anti-tumour agent EO9

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

Chemotherapy as an adjunct to radiation in the treatment of squamous cell carcinoma of the head and neck: results of the Yale Mitomycin Randomized Trials.

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

Bioreductive agents, hypoxic cells and therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

Antibody-directed enzyme prodrug therapy (ADEPT).

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

Gene therapy for cancer: what have we done and where are we going?

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

The expression of bacterial nitroreductase in transgenic mice results in specific cell killing by the prodrug CB1954.

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

An experimental and mathematical model for the extravascular transport of a DNA intercalator in tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

Multilayers of cells growing on a permeable support. An in vitro tumour model

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

The experimental development of bioreductive drugs and their role in cancer therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

Targeting gene expression to hypoxic tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0360-3016%2898%2900302-2

7 January 2021

10.1016/S0360-3016(98)00302-2

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9845091%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

1 reference