(Q41099312)

English

Adaptation of human tumor cells to tirapazamine under aerobic conditions: implications of increased antioxidant enzyme activity to mechanism of aerobic cytotoxicity

scientific article published on July 1997

In more languages

default values for all languages

No label defined

No description defined

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

Adaptation of human tumor cells to tirapazamine under aerobic conditions: implications of increased antioxidant enzyme activity to mechanism of aerobic cytotoxicity (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

0 references

author name string

Elwell JH

1

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

Siim BG

2

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

Evans JW

3

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

Brown JM

4

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

language of work or name

0 references

publication date

1 July 1997

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

Biochemical Pharmacology

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

54

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

249-257

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

Tumor hypoxia: its impact on cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

Bioreducible mustards: a paradigm for hypoxia-selective prodrugs of diffusible cytotoxins (HPDCs).

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

The experimental development of bioreductive drugs and their role in cancer therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

Reoxygenation and rehypoxiation in the SCCVII mouse tumor

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

Tumor hypoxia can be exploited to preferentially sensitize tumors to fractionated irradiation

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-l,2,4-benzotriazine-l ,4-dioxide (SR 4233, WIN 59075) by mouse liver

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

Metabolism of the bioreductive cytotoxin SR 4233 by tumour cells: enzymatic studies

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

Reductive metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) and the induction of unscheduled DNA synthesis in rat and human derived cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

Muscle cramping in phase I clinical trials of tirapazamine (SR 4233) with and without radiation

2 references

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a phase I trial

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

A thin-film culturing technique allowing rapid gas-liquid equilibration (6 sec) with no toxicity to mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

An assay for superoxide dismutase activity in mammalian tissue homogenates

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

Regional distribution of catalase in the adult rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

Glutathione peroxidase activity in selenium-deficient rat liver

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

Importance of P450 reductase activity in determining sensitivity of breast tumour cells to the bioreductive drug, tirapazamine (SR 4233).

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

The effects of three bioreductive drugs (mitomycin C, RSU-1069 and SR4233) on cell lines selected for their sensitivity to mitomycin C or ionising radiation

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

Molecular mechanisms of SR 4233-induced hepatocyte toxicity under aerobic versus hypoxic conditions

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

Protection against SR 4233 (Tirapazamine) aerobic cytotoxicity by the metal chelators desferrioxamine and tiron

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

SR-4233 (Tirapazamine) acts as an uncoupler of oxidative phosphorylation in human MCF-7 breast carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

The Role of NAD(P)H: Quinone Reductase (EC 1.6.99.2, DT-Diaphorase) in the Reductive Bioactivation of the Novel Indoloquinone Antitumor Agent E09

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

The nitroreductase enzyme in walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

Enzymology of the reduction of the potent benzotriazine-di-n-oxide hypoxic cell cytotoxin SR 4233 (win 59075) by NAD(P)H: (Quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from walker 256 rat tumour cells

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

The role of DT-diaphorase in determining the sensitivity of human tumor cells to tirapazamine (SR 4233).

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

Unusually marked hypoxic sensitization to indoloquinone EO9 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9.

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

Tirapazamine-induced DNA damage measured using the comet assay correlates with cytotoxicity towards hypoxic tumour cells in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900171-8

7 January 2021

Identifiers

10.1016/S0006-2952(97)00171-8

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q41099312&oldid=2093478181"