(Q68232111)

English

The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-l,2,4-benzotriazine-l ,4-dioxide (SR 4233, WIN 59075) by mouse liver

scientific article published on July 22, 1992

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22 September 2019

The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233, WIN 59075) by mouse liver (English)

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22 September 2019

The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-l,2,4-benzotriazine-l ,4-dioxide (SR 4233, WIN 59075) by mouse liver (English)

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10.1016/0006-2952(92)90007-6

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20 October 2022

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20 October 2022

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20 October 2022

author name string

M. I. Walton

1

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20 October 2022

C. R. Wolf

2

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20 October 2022

P. Workman

3

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1 July 1992

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22 September 2019

22 July 1992

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20 October 2022

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Biochemical Pharmacology

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22 September 2019

251-259

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SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells

1

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Structure-activity relationships for benzotriazine di-N-oxides

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Molecular mechanisms for the hypoxia-dependent activation of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233)

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Microsomal reduction of 3-amino-1,2,4-benzotriazine 1,4-dioxide to a free radical

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Molecular enzymology of the reductive bioactivation of hypoxic cell cytotoxins

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Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin

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Identification of two major reduction products of the hypoxic cell toxin 3-amino-1,2,4-benzotriazine-1,4-dioxide

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Reductive metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) and the induction of unscheduled DNA synthesis in rat and human derived cell lines

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Immunological comparison of rat, rabbit, and human liver NADPH-cytochrome P-450 reductases

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Nitroimidazole bioreductive metabolism. Quantitation and characterisation of mouse tissue benznidazole nitroreductases in vivo and in vitro

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High-performance liquid chromatographic assay for the benzotriazine di-N-oxide (SR 4233) and its reduced metabolites in biological materials

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Reduction of tertiary amine N-oxides by liver microsomal cytochrome P-450

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Enzymology of the reduction of the potent benzotriazine-di-n-oxide hypoxic cell cytotoxin SR 4233 (win 59075) by NAD(P)H: (Quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from walker 256 rat tumour cells

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Identifiers

10.1016/0006-2952(92)90007-6

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1642640%20AND%20SRC:MED&resulttype=core&format=json

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1 reference

Europe PubMed Central

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22 September 2019

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