(Q78079534)

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Gas chromatography-negative ion chemical ionization mass spectrometry as a powerful tool for the detection of mercapturic acids and DNA and protein adducts as biomarkers of exposure to halogenated olefins

scientific article published on 01 June 1999

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10 December 2019

Gas chromatography-negative ion chemical ionization mass spectrometry as a powerful tool for the detection of mercapturic acids and DNA and protein adducts as biomarkers of exposure to halogenated olefins (English)

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10 December 2019

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Wolfgang Völkel

1

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10 December 2019

author name string

A Pähler

2

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10 December 2019

W Dekant

3

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1 June 1999

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10 December 2019

Journal of Chromatography

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10 December 2019

847

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10 December 2019

35-46

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10 December 2019

1-2

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10 December 2019

Human biomonitoring and the 32P-postlabeling assay

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Mercapturic acids, protein adducts, and DNA adducts as biomarkers of electrophilic chemicals

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Metabolism of tetrachloroethene in rats: identification of N epsilon-(dichloroacetyl)-L-lysine and N epsilon-(trichloroacetyl)-L-lysine as protein adducts

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Bioactivation of nephrotoxic haloalkenes by glutathione conjugation: formation of toxic and mutagenic intermediates by cysteine conjugate beta-lyase

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Bacterial beta-lyase mediated cleavage and mutagenicity of cysteine conjugates derived from the nephrocarcinogenic alkenes trichloroethylene, tetrachloroethylene and hexachlorobutadiene

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Biosynthesis, bioactivation, and mutagenicity of S-conjugates

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Immunochemical detection of protein adducts in mice treated with trichloroethylene.

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The lipoic acid containing components of the 2-oxoacid dehydrogenase complexes mimic trifluoroacetylated proteins and are autoantigens associated with halothane hepatitis

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Reactivity of haloketenes and halothioketenes with nucleobases: chemical characterization of reaction products

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Identification of S-1,2,2-trichlorovinyl-N-acetylcysteine as a urinary metabolite of tetrachloroethylene: bioactivation through glutathione conjugation as a possible explanation of its nephrocarcinogenicity

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7 January 2021

Vinyl chloride-induced DNA adducts. I: Quantitative determination of N2,3-ethenoguanine based on electrophore labeling

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Generation of antibodies to Di- and trichloroacetylated proteins and immunochemical detection of protein adducts in rats treated with perchloroethene

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Quantitation of the tetrachloroethylene metabolite N-acetyl-S-(trichlorovinyl)cysteine in rat urine via negative ion chemical ionization gas chromatography/tandem mass spectrometry

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7 January 2021

Biotransformation of trichloroethene: dose-dependent excretion of 2,2,2-trichloro-metabolites and mercapturic acids in rats and humans after inhalation.

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Reactivity of haloketenes and halothioketenes with nucleobases: reactions in vitro with DNA

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Molecular biomarkers for human chemical carcinogen exposures

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Hydroxyethylation of hemoglobin by 1-(2-chloroethyl)-1-nitrosoureas

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Detection of human exposure to carcinogens by measurement of alkyl-DNA adducts using immunoaffinity clean-up in combination with gas chromatography-mass spectrometry and other methods of quantitation

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7 January 2021

Mercapturic acids as biomarkers of exposure to electrophilic chemicals:applications to environmental and industrial chemicals.

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Analysis of DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine in rat and human tissues by alkaline hydrolysis and gas chromatography/electron capture mass spectrometry: validation by comparison with 32P-postlabeling

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7 January 2021

Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver

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Etheno adducts formed in DNA of vinyl chloride-exposed rats are highly persistent in liver

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Applications of mass spectrometry to toxicology

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7 January 2021

Identifiers

10.1016/S0021-9673(99)00022-9

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10431350%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10431350%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

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