(Q38625462)

English

Bioactivation of nephrotoxic haloalkenes by glutathione conjugation: formation of toxic and mutagenic intermediates by cysteine conjugate beta-lyase

scientific article published on January 1989

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

1 reference

Europe PubMed Central

Bioactivation of nephrotoxic haloalkenes by glutathione conjugation: formation of toxic and mutagenic intermediates by cysteine conjugate beta-lyase (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

1 reference

based on heuristic

inferred from title

author name string

Dekant W

1

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

Vamvakas S

2

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

Anders MW

3

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

language of work or name

0 references

publication date

1 January 1989

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

Drug Metabolism Reviews

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

20

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

43-83

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

Metabolism of dihalomethanes to formaldehyde and inorganic halide--II. Studies on the mechanism of the reaction

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Metabolism of haloforms to carbon monoxide--III. Studies on the mechanism of the reaction

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

The mutagenic effect of 1,2-dichloroethane on Salmonella typhimurium I. Activation through conjugation with glutathion in vitro

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Evidence for formation of an S-[2-(N7-guanyl)ethyl]glutathione adduct in glutathione-mediated binding of the carcinogen 1,2-dibromoethane to DNA.

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

S-[2-(N7-guanyl)ethyl]glutathione, the major DNA adduct formed from 1,2-dibromoethane.

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Formation of S-[2-(N7-guanyl)ethyl] adducts by the postulated S-(2-chloroethyl)cysteinyl and S-(2-chloroethyl)glutathionyl conjugates of 1,2-dichloroethane

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Glutathione- and cysteine-mediated cytotoxicity of allyl and benzyl isothiocyanate.

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

The metabolism and nephrotoxicity of tetrafluoroethylene in the rat.

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Structure/activity studies of the nephrotoxic and mutagenic action of cysteine conjugates of chloro- and fluoroalkenes

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Identification of S-1,2-dichlorovinyl-N-acetyl-cysteine as a urinary metabolite of trichloroethylene: a possible explanation for its nephrocarcinogenicity in male rats.

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

The metabolism and disposition of hexachloro-1:3-butadiene in the rat and its relevance to nephrotoxicity

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Cellular effects of reactive intermediates: nephrotoxicity of S-conjugates of amino acids

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Biosynthesis and biotransformation of glutathione S-conjugates to toxic metabolites

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Results of a two year chronic toxicity study with hexachlorobutadiene in rats

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Metabolism of hexachloro-1,3-butadiene in mice: in vivo and in vitro evidence for activation by glutathione conjugation

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Mercapturic acid formation is an activation and intermediary step in the metabolism of hexachlorobutadiene.

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Generation and inhalation toxicity of dichloroacetylene

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Carcinogenicity of dichloroacetylene: an inhalation study.

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Studies on the GABA pathway. I. The inhibition of gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase in vitro and in vivo by U-7524 (amino-oxyacetic acid).

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Short-term toxicity and reproduction studies in rats with hexachloro-(1,3)-butadiene

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Effect of the organic acid transport inhibitor probenecid on renal cortical uptake and proximal tubular toxicity of hexachloro-1,3-butadiene and its conjugates.

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

The mechanism of pentachlorobutadienyl-glutathione nephrotoxicity studied with isolated rat renal epithelial cells

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Coupling of active ion transport and aerobic respiratory rate in isolated renal tubules

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

A mechanism of S-(1,2,3,4,4-pentachloro-1,3-butadienyl)-L-cysteine toxicity to rabbit renal proximal tubules

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Bacterial beta-lyase mediated cleavage and mutagenicity of cysteine conjugates derived from the nephrocarcinogenic alkenes trichloroethylene, tetrachloroethylene and hexachlorobutadiene

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Mutagenicity of amino acid and glutathione S-conjugates in the Ames test

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Enzymatic transformation of mercapturic acids derived from halogenated alkenes to reactive and mutagenic intermediates

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Mutagenicity of hexachloro-1,3-butadiene and its S-conjugates in the Ames test--role of activation by the mercapturic acid pathway in its nephrocarcinogenicity

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Bacterial cysteine conjugate beta-lyase and the metabolism of cysteine S-conjugates: structural requirements for the cleavage of S-conjugates and the formation of reactive intermediates

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Genotoxic and mutagenic assays of halothane metabolites in bacillus subtilis and salmonella typhimurium

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Bioactivation mechanism of the cytotoxic and nephrotoxic S-conjugate S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

The origin and characteristics of a pig kidney cell strain, LLC-PK

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Glutathione S-conjugate formation from 1-chloro-2,4-dinitrobenzene and biliary S-conjugate excretion in the perfused rat liver

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Structural and functional polarity of canalicular and basolateral plasma membrane vesicles isolated in high yield from rat liver

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Thioacylating intermediates as metabolites of S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2,2-trichlorovinyl)-L-cysteine formed by cysteine conjugate beta-lyase

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Thioacylating agents as ultimate intermediates in the beta-lyase catalysed metabolism of S-(pentachloro-butadienyl)-L-cysteine

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

The fate of extracellular glutathione in the rat☆

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

The interorgan metabolism of glutathione

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Glutathione: interorgan translocation, turnover, and metabolism

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Assessment of the kidney function in maintenance of plasma glutathione concentration and redox state in anaesthetized rats

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Formation and metabolism of a glutathione-S-conjugate in isolated rat liver and kidney cells.

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Immunocytochemical localization of gamma-glutamyltransferase in rat kidney with protein A-horseradish peroxidase

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Transport of glutathione by renal basal-lateral membrane vesicles

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Transport of N-acetyl-S-pentachloro-1,3-butadienylcysteine by rat renal cortex

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Role of plasma albumin in renal elimination of a mercapturic acid. Analyses in normal and mutant analbuminemic rats.

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Chemically induced nephrotoxicity: role of metabolic activation

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Methylthlolated Metabolites

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Metabolic activation and detoxication of nephrotoxic cysteine and homocysteine S-conjugates

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Evidence for the active renal secretion of S-pentachlorophenyl-N-acetyl-L-cysteine by female rats

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Novel metabolites of trichloroethylene through dechlorination reactions in rats, mice and humans.

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Absorption, elimination and metabolism of trichloroethylene: a quantitative comparison between rats and mice.

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Species differences in response to trichloroethylene. II. Biotransformation in rats and mice.

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Chemical Mechanisms of Halocarbon Metabolism

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

A review of the environmental and mammalian toxicology of nitrilotriacetic acid

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Ion regulation, cell injury and carcinogenesis.

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

2,2,4-Trimethylpentane-induced nephrotoxicity. II. The reversible binding of a TMP metabolite to a renal protein fraction containing alpha 2u-globulin

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Differentiation of genetic versus epigenetic mechanisms of toxicity and its application to risk assessment

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Urinary Metabolites of 14C-Tetrachloroethylene in Mice

1 reference

https://api.crossref.org/works/10.3109%2F03602538908994144

21 January 2018

Identifiers

10.3109/03602538908994144

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q38625462&oldid=1771296519"