(Q78732204)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507224%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

review article

1 reference

title

Pharmacogenomics in cancer drug discovery and development: inhibitors of the Hsp90 molecular chaperone (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507224%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

0 references

1 reference

Paul Workman

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507224%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

publication date

1 January 2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507224%20AND%20SRC:MED&resulttype=core&format=json

Cancer Detection and Prevention

16 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507224%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

volume

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507224%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507224%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

page(s)

405-410

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507224%20AND%20SRC:MED&resulttype=core&format=json

Discovering novel chemotherapeutic drugs for the third millennium

16 December 2019

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Initial sequencing and analysis of the human genome

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7 January 2021

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7 January 2021

HSP90 as a new therapeutic target for cancer therapy: the story unfolds

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7 January 2021

Role of the heat shock response and molecular chaperones in oncogenesis and cell death

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7 January 2021

Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators

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7 January 2021

Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity

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7 January 2021

DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90

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7 January 2021

Heat shock proteins: new keys to the development of cytoprotective therapies

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7 January 2021

The benzoquinone ansamycin geldanamycin stimulates proteolytic degradation of focal adhesion kinase

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7 January 2021

Requirement of Hsp90 for centrosomal function reflects its regulation of Polo kinase stability

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7 January 2021

Do heat shock proteins have a role in breast cancer?

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7 January 2021

Unusual expression and localization of heat-shock proteins in human tumor cells

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7 January 2021

Prognostic significance of heat shock proteins 27 and 70 in patients with squamous cell carcinoma of the esophagus

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7 January 2021

Clinical and biological significance of HSP89 alpha in human breast cancer

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7 January 2021

Over-expression of heat shock proteins in carcinogenic endometrium

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7 January 2021

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

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7 January 2021

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

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7 January 2021

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

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7 January 2021

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

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7 January 2021

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

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7 January 2021

Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone.

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7 January 2021

Proliferation, cell cycle and apoptosis in cancer

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7 January 2021

The Hallmarks of Cancer

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7 January 2021

Geldanamycin-induced cytotoxicity in human colon-cancer cell lines: evidence against the involvement of c-Src or DT-diaphorase

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7 January 2021

Gene expression microarray analysis in cancer biology, pharmacology, and drug development: progress and potential.

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7 January 2021

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

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7 January 2021

Hsp90 as a capacitor for morphological evolution

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7 January 2021

Establishment of an isogenic human colon tumor model for NQO1 gene expression: application to investigate the role of DT-diaphorase in bioreductive drug activation in vitro and in vivo.

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7 January 2021

Assays for HSP90 and inhibitors.

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7 January 2021

10.1016/S0361-090X(02)00126-5

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507224%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

1 reference