(Q78880907)

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An analysis of replicative senescence in dermal fibroblasts derived from chronic leg wounds predicts that telomerase therapy would fail to reverse their disease-specific cellular and proteolytic phenotype

scientific article published on 01 February 2003

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17 December 2019

An analysis of replicative senescence in dermal fibroblasts derived from chronic leg wounds predicts that telomerase therapy would fail to reverse their disease-specific cellular and proteolytic phenotype (English)

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17 December 2019

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Christopher J Jones

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17 December 2019

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17 December 2019

David W. Thomas

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17 December 2019

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Phil Stephens

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17 December 2019

Helen Cook

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17 December 2019

Joanne Hilton

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17 December 2019

Michèle F Haughton

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17 December 2019

Fiona S Wyllie

6

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17 December 2019

Julia W Skinner

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17 December 2019

David Kipling

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17 December 2019

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1 February 2003

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17 December 2019

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Experimental Cell Research

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17 December 2019

283

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17 December 2019

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17 December 2019

22-35

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17 December 2019

How might replicative senescence contribute to human ageing?

1 reference

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7 January 2021

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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7 January 2021

The serial cultivation of human diploid cell strains

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7 January 2021

Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.

1 reference

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7 January 2021

Oxidative DNA damage as a marker of aging in WI-38 human fibroblasts.

1 reference

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7 January 2021

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

1 reference

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7 January 2021

Features of replicative senescence induced by direct addition of antennapedia-p16INK4A fusion protein to human diploid fibroblasts

1 reference

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7 January 2021

Senescence of human fibroblasts induced by oncogenic Raf.

1 reference

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7 January 2021

Replicative senescence: implications for in vivo aging and tumor suppression

1 reference

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7 January 2021

Telomeres, replicative senescence and human ageing

1 reference

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7 January 2021

Fibroblast heterogeneity in the healing wound

1 reference

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7 January 2021

A comparison of the ability of intra-oral and extra-oral fibroblasts to stimulate extracellular matrix reorganization in a model of wound contraction

1 reference

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7 January 2021

An investigation of preferential fibroblast wound repopulation using a novel in vitro wound model

1 reference

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7 January 2021

Skin and oral fibroblasts exhibit phenotypic differences in extracellular matrix reorganization and matrix metalloproteinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900021-6

7 January 2021

Fibroblasts cultured from venous ulcers display cellular characteristics of senescence

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900021-6

7 January 2021

Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900021-6

7 January 2021

Microarray analysis of replicative senescence

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900021-6

7 January 2021

Dermal fibroblasts from venous ulcers are unresponsive to the action of transforming growth factor-beta 1

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900021-6

7 January 2021

Venous ulcer fibroblasts compared with normal fibroblasts show differences in collagen but not fibronectin production under both normal and hypoxic conditions

1 reference

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7 January 2021

Reduced growth of dermal fibroblasts from chronic venous ulcers can be stimulated with growth factors

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900021-6

7 January 2021

Fibroblast senescence in pressure ulcers

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900021-6

7 January 2021

Proliferation and mitogenic response to PDGF-BB of fibroblasts isolated from chronic venous leg ulcers is ulcer-age dependent.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900021-6

7 January 2021

Defective extracellular matrix reorganization by chronic wound fibroblasts is associated with alterations in TIMP-1, TIMP-2, and MMP-2 activity

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900021-6

7 January 2021

Genes involved in senescence and immortalization

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900021-6

7 January 2021

Telomerase: immortality enzyme or oncogene?

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900021-6

7 January 2021

Telomere length and replicative aging in human vascular tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900021-6

7 January 2021

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

1 reference

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7 January 2021

Extension of life-span by introduction of telomerase into normal human cells

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900021-6

7 January 2021

Absence of cancer-associated changes in human fibroblasts immortalized with telomerase

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900021-6

7 January 2021

Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900021-6

7 January 2021

Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900021-6

7 January 2021

Cell attachment properties of collagen type VI and Arg-Gly-Asp dependent binding to its alpha 2(VI) and alpha 3(VI) chains

1 reference

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7 January 2021

Fabrication and reorganization of dermal equivalents suitable for skin grafting after major cutaneous injury.

1 reference

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7 January 2021

Isolation and identification of canine matrix metalloproteinase-2 (MMP-2).

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7 January 2021

Doubling potential, calendar time, and donor age of human diploid cells in culture

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900021-6

7 January 2021

The proliferative capacity of neonatal skin fibroblasts is reduced after exposure to venous ulcer wound fluid: A potential mechanism for senescence in venous ulcers

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900021-6

7 January 2021

The effect of passage number on fibroblast cellular senescence in patients with chronic venous insufficiency with and without ulcer

1 reference

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7 January 2021

Senescence and the healing rates of venous ulcers

1 reference

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7 January 2021

Increased organization of cytoskeleton accompanying the aging of human fibroblasts in vitro

1 reference

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7 January 2021

Late passage cells display an increase in contractile behavior

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900021-6

7 January 2021

Changes in cellular motility and cytoskeletal actin in fibroblasts from patients with chronic venous insufficiency and in neonatal fibroblasts in the presence of chronic wound fluid

1 reference

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7 January 2021

The genetics of cellular senescence

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7 January 2021

Dynamic forces in the cell cycle affecting fibroblasts in pressure ulcers

1 reference

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7 January 2021

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900021-6

7 January 2021

Telomere length predicts replicative capacity of human fibroblasts

1 reference

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7 January 2021

Telomeres shorten during ageing of human fibroblasts

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7 January 2021

Telomere end-replication problem and cell aging

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7 January 2021

Telomeres and telomerase in aging and cancer

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7 January 2021

Replicative senescence: the human fibroblast comes of age.

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7 January 2021

In vitro foetal wound contraction: the effect of amniotic fluid

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In vitro adhesion of mouse fetal germ cells to extracellular matrix components.

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7 January 2021

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Adhesion of human dermal reticular fibroblasts on complementary fragments of fibronectin: aging in vivo or in vitro

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7 January 2021

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7 January 2021

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Gelatinase A activation is regulated by the organization of the polymerized actin cytoskeleton

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Age-related differences in the temporal and spatial regulation of matrix metalloproteinases (MMPs) in normal skin and acute cutaneous wounds of healthy humans

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7 January 2021

Expression of 72-kDa gelatinase and TIMP-2 in early and late passage human fibroblasts.

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7 January 2021

Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts

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7 January 2021

Human ageing impairs injury-induced in vivo expression of tissue inhibitor of matrix metalloproteinases (TIMP)-1 and -2 proteins and mRNA.

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Identifiers

10.1016/S0014-4827(02)00021-6

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12565817%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12565817%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

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