(Q79280859)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17054019%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

title

Molecular dynamics simulations on the inhibition of cyclin-dependent kinases 2 and 5 in the presence of activators (English)

1 reference

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20 December 2019

2

1 reference

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20 December 2019

Kian-Meng Lim

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17054019%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

Tong-Earn Tay

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17054019%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

author name string

Bing Zhang

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17054019%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

publication date

1 June 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17054019%20AND%20SRC:MED&resulttype=core&format=json

Journal of Computer - Aided Molecular Design

20 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17054019%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

volume

20

1 reference

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20 December 2019

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17054019%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

page(s)

395-404

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17054019%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s10822-006-9081-z

20 December 2019

exact match

0 references

cites work

Role of cdk5 in the pathogenesis of Alzheimer's disease

1 reference

12 December 2020

CDK inhibition and cancer therapy

1 reference

12 December 2020

Loop flexibility and solvent dynamics as determinants for the selective inhibition of cyclin-dependent kinase 4: comparative molecular dynamics simulation studies of CDK2 and CDK4.

1 reference

12 December 2020

Interaction of amiloride and one of its derivatives with Vpu from HIV-1: a molecular dynamics simulation

1 reference

12 December 2020

Cyclin-dependent kinase 5 in amyotrophic lateral sclerosis

1 reference

12 December 2020

Structure and regulation of the CDK5-p25(nck5a) complex

1 reference

12 December 2020

Small molecules as inhibitors of cyclin-dependent kinases

1 reference

12 December 2020

Molecular model of cyclin-dependent kinase 5 complexed with roscovitine

1 reference

12 December 2020

The mechanism of inhibition of the cyclin-dependent kinase-2 as revealed by the molecular dynamics study on the complex CDK2 with the peptide substrate HHASPRK

1 reference

12 December 2020

Roscovitine targets, protein kinases and pyridoxal kinase

1 reference

12 December 2020

Complexities in the development of cyclin-dependent kinase inhibitor drugs

1 reference

12 December 2020

Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

1 reference

12 December 2020

Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine

1 reference

12 December 2020

Protein kinase inhibitors: insights into drug design from structure.

1 reference

12 December 2020

A computational model of binding thermodynamics: the design of cyclin-dependent kinase 2 inhibitors

1 reference

12 December 2020

Cyclin-Dependent Kinases

1 reference

12 December 2020

Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age

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12 December 2020

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1 reference

12 December 2020

Exploiting structural principles to design cyclin-dependent kinase inhibitors.

1 reference

12 December 2020

Pharmacological inhibitors of cyclin-dependent kinases

1 reference

12 December 2020

The therapeutic potential of targeting the cell cycle

1 reference

12 December 2020

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

1 reference

12 December 2020

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?

1 reference

12 December 2020

Cyclin-dependent kinase inhibitors: useful targets in cell cycle regulation

1 reference

12 December 2020

Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors

1 reference

12 December 2020

The cyclin-dependent kinase inhibitor roscovitine inhibits RNA synthesis and triggers nuclear accumulation of p53 that is unmodified at Ser15 and Lys382.

1 reference

12 December 2020

Inhibitor binding to active and inactive CDK2: the crystal structure of CDK2-cyclin A/indirubin-5-sulphonate

1 reference

12 December 2020

Study of a ligand complexed with Cdk2/Cdk4 by computer simulation

1 reference

12 December 2020

Activation and inhibition of cyclin-dependent kinase-2 by phosphorylation; a molecular dynamics study reveals the functional importance of the glycine-rich loop

1 reference

12 December 2020

Dynamics and binding modes of free cdk2 and its two complexes with inhibitors studied by computer simulations

1 reference

12 December 2020

Cdk5 as a drug target for the treatment of Alzheimer's disease

1 reference

12 December 2020

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

1 reference

12 December 2020

Small-molecule inhibitors of the cell cycle

1 reference

12 December 2020

Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease

1 reference

12 December 2020

1 reference

12 December 2020

Animal cell cycles and their control

1 reference

12 December 2020

p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway.

1 reference

12 December 2020

Three-dimensional model of the cyclin-dependent kinase 1 (CDK1): Ab initio active site parameters for molecular dynamics studies of CDKS

1 reference

12 December 2020

Deregulation of cdk5, hyperphosphorylation, and cytoskeletal pathology in the Niemann-Pick type C murine model.

1 reference

12 December 2020

The effect of a tightly bound water molecule on scaffold diversity in the computer-aided de novo ligand design of CDK2 inhibitors.

1 reference

12 December 2020

The dynamics of cyclin dependent kinase structure

1 reference

12 December 2020

Structural basis of cyclin-dependent kinase activation by phosphorylation

1 reference

12 December 2020

10.1007/S10822-006-9081-Z

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17054019%20AND%20SRC:MED&resulttype=core&format=json

journals/jcamd/ZhangTLT06

20 December 2019

DBLP publication ID

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference