(Q79793647)

English

Role of the MPN subunits in COP9 signalosome assembly and activity, and their regulatory interaction with Arabidopsis Cullin3-based E3 ligases

scientific article published on 16 February 2007

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scholarly article

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25 December 2019

Role of the MPN subunits in COP9 signalosome assembly and activity, and their regulatory interaction with Arabidopsis Cullin3-based E3 ligases (English)

1 reference

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25 December 2019

COP9 signalosome assembly

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Gene Ontology release 2020-05-02

Gene Ontology ID

Pablo M Figueroa

2

1 reference

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25 December 2019

author name string

Giuliana Gusmaroli

1

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25 December 2019

Giovanna Serino

3

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25 December 2019

Xing Wang Deng

4

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25 December 2019

publication date

16 February 2007

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25 December 2019

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25 December 2019

19

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25 December 2019

564-581

1 reference

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25 December 2019

2

1 reference

Europe PubMed Central

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25 December 2019

Arabidopsis CUL3A and CUL3B genes are essential for normal embryogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neddylation and deneddylation regulate Cul1 and Cul3 protein accumulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transactivation of Schizosaccharomyces pombe cdt2+ stimulates a Pcu4-Ddb1-CSN ubiquitin ligase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The emerging role of the COP9 signalosome in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection of cullin-RING E3 ligases by CSN-UBP12.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arabidopsis CULLIN4 Forms an E3 Ubiquitin Ligase with RBX1 and the CDD Complex in Mediating Light Control of Development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CUL4 associates with DDB1 and DET1 and its downregulation affects diverse aspects of development in Arabidopsis thaliana.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The COP9 signalosome regulates Skp2 levels and proliferation of human cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nedd8 on cullin: building an expressway to protein destruction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NEDD8 recruits E2-ubiquitin to SCF E3 ligase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role of Arabidopsis COP9 signalosome in multifaceted developmental processes revealed by the characterization of its subunit 3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular characterization of subunit 6 of the COP9 signalosome and its role in multifaceted developmental processes in Arabidopsis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A recessive mutation in the RUB1-conjugating enzyme, RCE1, reveals a requirement for RUB modification for control of ethylene biosynthesis and proper induction of basic chitinase and PDF1.2 in Arabidopsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The COP9 signalosome: mediating between kinase signaling and protein degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Related to ubiquitin 1 and 2 are redundant and essential and regulate vegetative growth, auxin signaling, and ethylene production in Arabidopsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ubiquitin 26S proteasome proteolytic pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple functions of Jab1 are required for early embryonic development and growth potential in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arabidopsis COP9 is a component of a novel signaling complex mediating light control of development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arabidopsis COP8, COP10, and COP11 genes are involved in repression of photomorphogenic development in darkness.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The COP9 complex, a novel multisubunit nuclear regulator involved in light control of a plant developmental switch

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for FUS6 as a component of the nuclear-localized COP9 complex in Arabidopsis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The PCI domain: a common theme in three multiprotein complexes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The COP9 signalosome is essential for development of Drosophila melanogaster.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The COP9/signalosome complex is conserved in fission yeast and has a role in S phase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The NED-8 conjugating system in Caenorhabditis elegans is required for embryogenesis and terminal differentiation of the hypodermis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCFTIR1 in Mediating Auxin Response

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion mutants in COP9/signalosome subunits in fission yeast Schizosaccharomyces pombe display distinct phenotypes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CSN1 N-terminal-dependent activity is required for Arabidopsis development but not for Rub1/Nedd8 deconjugation of cullins: a structure-function study of CSN1 subunit of COP9 signalosome

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AXR1-ECR1-dependent conjugation of RUB1 to the Arabidopsis Cullin AtCUL1 is required for auxin response

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of SCF ubiquitin-ligase and the COP9 signalosome in the N gene-mediated resistance response to Tobacco mosaic virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the Arabidopsis RING-H2 protein RBX1 in RUB modification and SCF function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

COP9 signalosome subunits 4 and 5 regulate multiple pleiotropic pathways in Drosophila melanogaster

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple ubiquitin ligase-mediated processes require COP9 signalosome and AXR1 function

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The RUB/Nedd8 conjugation pathway is required for early development in Arabidopsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The COP9 Signalosome Interacts with SCFUFO and Participates in Arabidopsis Flower Development

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The COP9 Signalosome Interacts Physically with SCFCOI1 and Modulates Jasmonate Responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a physical association of the COP9 signalosome, the proteasome, and specific SCF E3 ligases in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The COP9 signalosome is an essential regulator of development in the filamentous fungus Aspergillus nidulans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genome-wide insertional mutagenesis of Arabidopsis thaliana

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The COP9 Signalosome

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arabidopsis homologs of a c-Jun coactivator are present both in monomeric form and in the COP9 complex, and their abundance is differentially affected by the pleiotropic cop/det/fus mutations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of two subunits of Arabidopsis 19S proteasome regulatory complex and its possible interaction with the COP9 complex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arabidopsis FUSCA5 encodes a novel phosphoprotein that is a component of the COP9 complex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arabidopsis cop8 and fus4 mutations define the same gene that encodes subunit 4 of the COP9 signalosome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Arabidopsis CSN5A and CSN5B subunits are present in distinct COP9 signalosome complexes, and mutations in their JAMM domains exhibit differential dominant negative effects on development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arabidopsis AtCUL3a and AtCUL3b form complexes with members of the BTB/POZ-MATH protein family.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small Jab1-containing subcomplex is regulated in an anchorage- and cell cycle-dependent manner, which is abrogated by ras transformation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CSN facilitates Cullin-RING ubiquitin ligase function by counteracting autocatalytic adapter instability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arabidopsis has two redundant Cullin3 proteins that are essential for embryo development and that interact with RBX1 and BTB proteins to form multisubunit E3 ubiquitin ligase complexes in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cullins 3a and 3b assemble with members of the broad complex/tramtrack/bric-a-brac (BTB) protein family to form essential ubiquitin-protein ligases (E3s) in Arabidopsis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of the CONSTITUTIVE PHOTOMORPHOGENIC9 signalosome subunit 5 is sufficient to cause the cop/det/fus mutant phenotype in Arabidopsis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The COP9 signalosome regulates the Neurospora circadian clock by controlling the stability of the SCFFWD-1 complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/17307927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1105/TPC.106.047571

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17307927%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17307927%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

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